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Biomedical subjects

B Kramann

Publications and source records attributed to B Kramann.

At least 73 records · Page 4Linked to original sources

[The significance of vascular surgery treatment of complications following percutaneous transluminal angioplasty of the lower extremities].

In 147 patients suffering from arterial occlusive disease of the lower extremities 162 PTAs of the iliac, femoral and popliteal arteries were performed. Thirteen complications occurred in 12 patients, while surgical intervention was necessary in seven cases (4.3%). Hematoma at the site of the arterial puncture were the most frequent complications, requiring acute surgical intervention (n = 3). In two patients, acute vascular occlusion after PTA required bypass operation and thrombendarteriectomy, respectively. In one patient, presenting with an iliac stenosis, PTA was performed using a transaxillar approach and was complicated by an axillar hematoma due to the ruptur of the arteria subscapularis. Furthermore, one patient with an extended hematoma of the abdominal wall required surgical intervention. The results presented indicate that PTA of the lower extremities for treatment of arterial occlusive disease is a procedure with low risk. Complications, which require acute operative therapy, can be treated mostly successful by small surgical interventions.

Angioplasty, Balloon↗

[Use of streptokinase and urokinase in deep venous thrombosis and pulmonary embolism: indications and clinical experience].

The efficacy of fibrinolysis in DVT is dependent upon the age and organization of the thrombus as well as its localization. In consequence, selective evaluation prior to determining the indication for thrombolytic therapy is just as important for therapeutic success as choosing the appropriate fibrinolytic agent. To improve the results of fibrinolysis a team of angiologists, hemostaseologists, radiologists and surgeons are cooperating in a special "thromboembolic care unit". Phlebographic criteria were defined which allow differentiation of fibrinolytic indications depending upon the site of the thrombus. Selection of the fibrinolytic agent and careful monitoring of the thrombolysis should ensure a maximum therapeutic effect with a minimum of bleeding complications. The duration of thrombolysis was established through phlebographic verification and functional tests with venous occlusion plethysmography. The cause and results of 108 cases of thrombolysis shall be presented.

Humans↗

[Gallbladder perforation on the computed tomogram].

Seven cases of perforated gallbladder disclosed by computed tomography are reported. In all cases the symptoms were obvious. As clinical signs and ultrasound do not always give reliable results, computer tomography plays an important rôle in the diagnosis of gallbladder perforation.

Acute Disease↗

Rupture of the spleen by penetration of pancreatic pseudocysts.

2 patients with known chronic recurrent pancreatitis and proven pancreatic pseudocysts in the tail of the pancreas developed a pseudocystic invasion of the spleen followed by tryptic erosion of it. This complication, previously seldom reported, occurred twice in one year, the diagnosis being achieved by CT.

Adult↗

[Premedication with H1- and H2-receptor antagonists for intravenous urography using contrast media].

Intravenous urography using Telebrix was performed on 500 patients. Two hundred patients (group I) received no pre-medication; 300 patients (group II) were premedicated with H1 and H2 receptor antagonists. All patients were examined for signs of contrast reactions, blood pressure, pulse rate and plasma histamine levels. These were measured before and three minutes after the administration of the antihistamine substances and/or the contrast medium, and also at the end of the examination. Following the administration of H1 and H2 receptor antagonists, a slight, transient and insignificant rise in plasma histamine could be demonstrated. Both groups showed a significant rise in plasma histamine levels after the injection of the contrast medium. Although the pre-medicated group contained a higher percentage of high risk patients, there were significantly fewer patients with contrast reactions. Pre-medication with H1 and H2 receptor antagonists in high risk patients is therefore advisable.

Adult↗

[Successful treatment of superior mesenteric artery thrombosis with local high-dose urokinase therapy].

A 56 year old man presented with increasing abdominal pain. He suffered from arterial occlusive disease with occlusion of the right A. iliaca communis. Angiography revealed partial thrombotic occlusion of the superior mesenteric artery. Urokinase (UK) at a dose of 150 IU/kg X minutes and heparin (1,000 U/h) was infused through the 7F angiographic catheter for 180 minutes. After 70 min of treatment, angiography showed improvement, and after 120 min the thrombus was nearly completely lysed. A stenosis of approximately 50% was still present after 180 min. Two hours after treatment the patient was pain free without analgesics. Laboratory studies showed systemic fibrinogenolysis, but fibrinogen was still within the upper normal range. Only slight systemic fibrinolytic activity (less than 5 IU UK/ml) could be determined. However, alpha 2-antiplasmin was depleted. The catheter was drawn 15 h after thrombolysis without bleeding. While under concurrent heparin and phenprocoumon therapy, the patient developed an infected gluteal hematoma as a result of i.m. injections prior to this treatment. A repeat angiography approximately one month after thrombolysis revealed further improvement and patency. The patient is well and free of abdominal angina and under oral anticoagulant therapy.

Drug Therapy, Combination↗

[Typical computed tomographic findings in neurofibromatosis].

Three patients with neurofibromatosis (Recklinghausen's disease) were examined by computer tomography. In this way, the exact extent and localisation of the neurofibromatous tumours could be demonstrated. In one patient, CT provided evidence of malignant change; this was verified histologically. The appearances of neurofibromatosis associated with elephantiasis is described. In each patient, treatment was significantly influenced by computer tomography.

Adolescent↗

Biliary drainage by teflon endoprosthesis in obstructive jaundice--experiences in 69 patients treated by PTCD or ERCD.

In 69 patients with extrahepatic biliary obstruction a specially designed teflon tube, the endoprosthesis, was inserted across the ductal stenosis either by percutaneous or by endoscopic route to reduce jaundice. After gaining experience our success rate of stent placement was more than 90%. Compared with catheter drainage the endoprosthesis worked faster and more efficiently, while in palliative treatment the quality of life of the patient improved and secondary cholangitis was prevented. The rate of significant long-term stent obstruction can be tolerated in view of the expected life span of four months as average in our material.

Adult↗

[Accuracy of endoscopic retrograde pancreatico-cholangiography in the diagnosis of pancreatic disease: an analysis of three thousand investigations (author's transl)].

Endoscopic retrograde pancreatico-cholangiography (ERPC) gave the correct diagnosis in 83% of 269 cases of pancreatitis confirmed by operation, clinical features, laboratory findings and course. It provided the correct diagnosis in 85% of 82 cases of necrosis of the pancreas and pseudocysts confirmed at operation. ERPC is one of the most important methods of investigation in papillary stenosis, because it can demonstrate both ducts and can reveal functional changes, especially delayed emptying. The correct diagnosis of carcinoma of the pancreas, confirmed at operation or histologically, was made in 88% of 107 cases. Endoscopy correctly diagnosed 26 of 27 cases of papillary carcinoma. Biopsy with subsequent histological study and cytological analysis of pancreatic secretion further served to confirm the diagnoses established by ERPC.

Ampulla of Vater↗

[Autologous vein grafts as artery replacement in microsurgery. An experimental study of micro- and macromorphologic changes 3 weeks to 12 months postoperatively].

In 45 rabbits we interposed autologous vein grafts of different length in equivalent defects of the femoral artery. After fixed intervals of six weeks to 12 months functional, histological and angiographic studies were done. Long grafts showed the same thrombus rate as short ones. The histological findings showed a marked thickening of the vessel wall with a maximum between six to eight weeks after operation. After this period this thickening was reduced but was after 12 months still noticeable. The angiography showed no signs of stenosis or narrowing of the lumen. Occasionally we saw bone formation or incrustation which might be induced by intima lesions.

Animals↗

Transvenous xeroarteriography: noninvasive method for demonstrating peripheral arteries.

Xeroradiography allows visualization of peripheral arteries after intravenous injection of relatively low quantities of contrast medium. By means of a special changer, several exposures are chosen according to standardized programs. Determination of the arrival time of the contrast medium after its passage through the heart and the lungs is not necessary. The method has proved effective in demonstration of localized vascular lesions and evaluation of postoperative status and soft tissue tumors. Transvenous examinations of 237 patients are reported.

Adult↗