Search PubMed⌕ Search

Biomedical subjects

B Konz

Publications and source records attributed to B Konz.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Multiple BCG-induced ulcers after subcutaneous vaccination in the framework of immunochemotherapy in malignant melanoma].

Immunochemotherapy combining dacarbazine with BCG is a possible therapeutic method for the adjuvant treatment of malignant melanomas. The routes of application of BCG, however, vary. As the case of a 61-year-old female shows, subcutaneous injection can lead to severe ulcerations, which respond to tuberculostatic therapy. Therefore scarifications seems to be preferable.

BCG Vaccine↗
PubMed1986

[Therapy and prognosis of malignant melanoma of the skin].

Since 1967 a total of 2403 patients with malignant melanoma have been treated according to a standardized regimen. The five-year survival rate for all patients in stage I was 79%. It was clearly dependent on tumour thickness or prognostic index, respectively. If tumour thickness was less than 0.75 mm or the prognostic index under 6, more than 90% survived for five years. With a tumour thickness of more than 3 mm or a prognostic index of greater than 13 the survival rate decreased to about 50%. Irrespective of tumour thickness the first signs of progression were local recurrence (20%), lymph-node metastases (50%), or distal metastases (30%). In case of progression symptoms recurred in about 80% within the first three years after tumour removal, in about 90% within five years. However, some 10% of progression signs occurred after more than five years. Prognosis was not significantly improved in stage I by adjuvant treatment with dacarbazine and BCG. In stage II the five-year survival rate was still about 30%. But in stage III only those patients with exclusively cutaneous distal metastases had a somewhat better prognosis. Only a few patients lived more than three years after the occurrence of organ metastases.

Adult↗
PubMed1983

[Malignant melanoma in lupus (tuberculosis cutis luposa)].

We report on a 72 years old man showing a strikingly fast spreading malignant melanoma developing on a lupus vulgaris which had existed since childhood. The coincidence of both diseases is obviously extremely rare. A pathogenetic relationship between melanoma and lupus vulgaris, such as claimed for carcinoma in lupo, especially after X-ray irradiation, is not inferable.

Aged↗
PubMed1982

[Congenital giant nevi. Clinical picture and therapy].

Congenital giant nevi are rare. There is high risk of malignant melanoma in large congenital nevi. Therefore the early operative removal is advised, not only for the prevention of malignant tumors, but also for psychologic and social reasons. The surgical and reconstructive methods include serial excisions, free skin-grafts and local pedicled flaps. The special advantages of free full-thickness grafts in the treatment of giant nevi in the facial region are outline.

Adult↗
PubMed1982

[Possibilities for tattoo removal. Report of experiences].

Different motivations are seen in patients with tattoos, which can be seen in a tattooed picture. Two kinds of tattoos can be distinguished: Professional and self-made tattoos. In general, patients with self-made tattoos call for their removal, because the private situation has changed. These tattoos are more difficult in treatment than professional ones, because the colour is located in the whole dermis. The method of treatment depends on size, form and shape of the tattoo. For treatment simple excision of small tattoos, dermabrasion in one or two sessions are recommended. Own experiences and results in 121 patients with tattoos are reported and discussed.

Dermabrasion↗
PubMed1982

[Coincidence of multiple cylindroma and trichoepitheliomas (Brooke-Spiegler-Syndrome)].

The coincidence of cyclindromas and trichoepitheliomas has been subject of a rather broad discussion for its principal pathogenetic aspects. Clinical cases, however, have only rarely been observed. Therefore, a case-report is given. Although the heredity of the Brooke-Spiegler syndrome seems well established by now, there is no anamnestic data in our case.

Adult↗
PubMed1981

Histological and cytological criteria in the diagnosis of malignant melanomas by cryostat sections.

Although cryostat sections in general allow a distinction to be made between malignant melanomas and other pigmented lesions in clinically doubtful cases, the differential diagnosis may be difficult. The histological and cytological criteria taken into account can be classified as major, minor, and insufficient. Knowing the diagnostic value of each makes a conventionally established diagnosis safer. Variance analysis does not contribute to the problem but it can nevertheless be shown that the evaluation of six major criteria makes a quick and reliable cryostat section diagnosis possible. If these results are confirmed in a prospective study it would be a decisive step on the way to a quicker and safer cryostat section diagnosis of malignant melanoma, even for the less experienced histopathologist.

Analysis of Variance↗
PubMed1980

[Diagnosis by intra-operative cryostatic section in suspected malignant melanoma (author's transl)].

In 233 (40.6%) of 535 patients referred for hospital treatment with a strong suspicion of melanoma, a diagnosis of malignant melanoma could be established on the grounds of the macroscopic clinical picture alone. In 302 patients (56.5%) a clinical diagnosis was not possible so that an intra-operative cryostatic section investigation was necessary to determine future operative measures. This gave a clear diagnosis of malignant melanoma in 101 (34.4%) patients and a benign pigmented skin tumor was established in 171 (56.6%) patients. In 14 cases (4.64%) no diagnosis could be made from the cryostatic investigation. In 16 (5.3%) patients diagnosis from cryostatic section had to be corrected after analysis of paraffin sections. Altogether an accuracy of over 85% was achieved.

Cryosurgery↗
PubMed1977

[Spinocellular carcinoma of the hand].

The proper treatment of squamous cell carcinoma of the hand is surgical only. Radical cure and preservation of function need not exclude one another if the following points are considered: praeoperative biopsy and intraoperative pathological examination, consideration of the degree of malignancy and the possibilities of surgical reconstruction.

Adult↗
PubMed1977

[Skin necroses following the use of a 2-per-cent Pyoctanin solution].

The case of a child is reported in whom a circumscribed necrotic skin reaction developed in the gluteal fold after application of 2% crystal violet (Pyoktanin) in aqueous solution. Similar cases are described after topical treatment with 1% solutions of dyes. For direct application to intertriginous areas, triphenylmethane dyes should be used in lower concentrations.

Buttocks↗
PubMed1975

Histographic surgery: accuracy of visual assessment of the margins of basal-cell epithelioma.

In 72 basal-cell epitheliomas, the clinical extension and the actual extension of the defect measured by complete tumor removal by Mohs' chemosurgery were compared. Subclinical extension depends on the type of basal-cell epithelioma (primary, recurrent), on case history, location, clinical diameter, number of previous treatments and histological type. It is remarkably great in large (diameter more than 20 mm), in morphea-like basal-cell epitheliomas on the forehead, temple and scalp, especially following several previous treatments. In such cases the excision should include at least a 5-10 mm margin of "normal tissue." Present results again show that "histographic," that is, Mohs' chemosurgery is the method of choice for the treatment for these tumors.

Basal Cell Carcinoma↗
PubMed1975

Use of skin flaps in dermatologic surgery of the face.

Different flap techniques for plastic repair of defects are described, namely, local flaps (advancement, transposition and rotation flaps) and regional flaps. Such use of skin of similar structure and pigmentation gives excellent cosmetic results. The indications for using local or regional flaps depends on size and location of the defect. Total extirpation of cutaneous malignancy particularly by microscopically monitored serial excision is a prerequisite to reconstruction.

Adult↗