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Biomedical subjects

B Klare

Publications and source records attributed to B Klare.

31 records · Page 2Linked to original sources
PubMed1980

[Haemofiltration in children. First experiences (author's transl)].

Haemofiltration was used in 12 children with terminal chronic renal failure. This method is an alternative for short-term treatment of renal failure by haemodialysis and can be combined with the single-needle-technique. It was also used in a 2 years old girl with acute renal failure. The main advantages of haemofiltration versus haemodialysis are a more rapid removal of fluid in the presence of stable blood pressure readings and a good tolerance by the patient. The primary indication for haemofiltration is hypervolaemia. The high water and salt losses during the procedure have to be exactly calculated and substituted. According to our current experience the volume needed for substitution of filtrate by fluid to be infused i.v. has to be in the range of 50% of body weight.

Acute Kidney Injury↗
PubMed1979

[Kidney transplantation in children].

Ten years' experience of renal transplantation in 40 children (aged 5--18 years) is reviewed. Including 3 second transplantations 40 cadaver grafts and 3 living donor grafts were transplanted. Mean graft survival was found to be 19 months, the longest being 8 years. At the time of last examination 24 children were alive wtith a functioning graft (mean serum creatinine level 1.5 mg/dl). After graft failure 9 children were again on intermittent hemodialysis. 7 children had died mainly because of infections or cardiovascular complications. Cumulative survival rate of patients and cadaver grafts after 2 years was 84 and 53% respectively. Growth velocity was variable but improved in the majority of patients compared to the previous dialysis period. Full social rehabilitation could be achieved in every case. Main complications were acute rejections (irreversible in 7 of 67), chronic rejections (irreversible in 6 of 10), side effects of immunosuppressive drugs (infections; hematologic, metabolic, and bone disorders), hypertension (60%), recurrence of primary renal disease (in 5 of 9 patients with focal segmental glomerulosclerosis) and surgical complications (28%). Therapeutic guide-lines are given emphasizing the role of specialized children's centres and the cooperation between pediatric nephrologists, immunologists, urologists and psychologists including the time before, during and after transplantation.

Adolescent↗
PubMed1978

Membranoproliferative glomerulonephritis in systemic sclerosis of childhood.

The renal lesions of a 5-year-old girl with progressive systemic sclerosis are described. The nephropathy was clinically characterised by moderate proteinuria, microscopic hematuria and transient hypertension. Light microscopy showed membranoproliferative glomerulonephritis of segmental character. On electron microscopy intramesangial, subendothelial and extramembranous glomerular deposits were observed. By immunofluorescence miscrosocpy deposit of IgG, Clq, C4, C3, C5, C8 and C9 in a predominantly subendothelial location were found in all glomeruli. Vascular lesions were of minor degree. Histological and immunohistological findings are compatible with an immune complex disease.

Child, Preschool↗
PubMedDate not supplied

[Treatment and prognosis of segmental renal hypoplasia].

Among 140 children with vesicorenal reflux 14 patients were found to be suffering from renal insufficiency. Seven of these patients had histologically proven bilateral segmental renal hypoplasia. Thanks to early commencement and sustainment of antihypertensive therapy, the prognosis of the condition was decisively improved. It does not appear to be worse than in other forms of reflux nephropathy at the renal insufficiency stage. Clinical courses in which there is no deterioration in renal function for more than 10 years are not uncommon. It is also possible to perform an anti-reflux plasty at the renal insufficiency stage. It is thus possible to permanently eliminate feverish infections of the urinary tract.

Adolescent↗