Changes in auditory evoked response induced by alcohol.
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
B Kissin
Publications and source records attributed to B Kissin.
Neurochemical correlates of alcohol preference in inbred strains of mice.
C57B1/6J, a specific inbred strain of mice with high alcohol preference and DBA/2J, a specific inbred strain with poor preference for alcohol were studied. Brain content of acetylcholine, uptake of 14C-Choline by whole brain homogenate were significantly higher in the C57B1/6J mice whereas brain acetylcholinesterase was higher in the DBA/2J mice. No significant difference was found for the level of brain serotonin, uptake of 3H-norepinephrine or 3H-dopamine. Treatment with a specific inhibitor of choline transferase, 4-(1-napthylvinyl) pyridine salt (10 mg/kg, twice daily) shifted the selection of alcohol to water in the C57B1/6J mice. These findings suggest a direct involvement of central cholinergic mechanism in alcohol preference.
Acetylcholine↗
Event-related brain potentials to high incentive stimuli in abstinent alcoholics.
We have previously found that the P3 component of the event-related potential (ERP) is reduced in alcoholics in visual target-selection paradigms. P3 voltage depends on the "subjective significance" of the stimulus (e.g., task relevance, probability of occurrence, motivational factors). We were interested in assessing P3s in alcoholics to motivationally significant stimuli that did not differ with respect to other aspects of significance. Equiprobable, task-relevant visual stimuli with different acquired incentive values were presented to alcoholics under baseline and two incentive conditions. Alcoholics manifested similar lower P3 voltages without P3 latency delays to all stimuli, regardless of incentive values. Latency Corrected Averages indicated that these results were not due to latency jitter in the averages. These results suggest multiple system deficits in alcoholics, perhaps in involving frontal and/or medial temporal lobe, the brain sources implicated in the generation of P3. Our results perhaps reflect a deficit in motivational-cognitive systems in alcoholics, possibly affecting their ability to actively sustain information processing.
Adolescent↗