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Biomedical subjects

B Kimmig

Publications and source records attributed to B Kimmig.

86 records · Page 5Linked to original sources
PubMed1983

A comparison of the effectiveness of 131I whole body scans and plasma Tg determinations in the diagnosis of metastatic differentiated carcinoma of the thyroid: a retrospective study.

In 68 patients with proved metastases of differentiated thyroid carcinoma the comparative value of the 131I whole body scan and plasma Tg measurements in establishing the diagnosis of metastasis or recurrence was analyzed retrospectively. At the time of primary therapy most metastases were diagnosed by the post-therapy scan (78%). Eight of 9 scintigraphic negative metastases in the post-therapy scan were indicated by elevated Tg levels (greater than 10 ng/ml). Twenty-four of 28 recurrences after a disease free interval were negative in the 2 mCi 131I scan, 18 of these patients were Tg positive. Of the 4 recurrences with positive 131I uptake all were Tg positive; two of them only during endogenous TSH stimulation. It is concluded that the routine 2 mCi whole body scan is less efficient in follow-up than is generally assumed. The most important follow-up parameter for these patients is the plasma Tg which can be obtained under suppressive therapy if a sensitive assay is used. In patients with a negative post-therapy scan and a negative Tg (less than 5 ng/ml) it seems justified to omit further 131I whole body control scans as long as Tg remains negative.

Carcinoma↗
PubMed1983

[Radiologic diagnosis of bone metastases].

Radiological diagnosis of bone metastases comprises multifarious examinations of varying diagnostic value. The incidence and topography of osseous metastases, as well as the x-ray morphological pattern, are described and the ranking of the various radiological methods discussed in detail. The diagnostic procedure to be followed in osseous metastases is explained on the basis of clinical examples, and the value of the individual methods in assessing the therapeutic effect is subjected to critical evaluation.

Adenocarcinoma↗
PubMed1983

[Nuclear medicine therapy of bone metastases].

The osteotropic radionuclides 89Sr and 32P are now mainly used in the treatment of bone metastases. This therapy is palliative and is mainly directed at alleviating pain. The indications, procedure, treatment result and side effects are described as discussed. Bone metastases of iodinophilous thyroid carcinomas represent a special case. These can be treated selectively with 131I. However, complete regression of the tumour by means of radioactive iodine is only rarely achieved in bone metastases. Nevertheless, the complaints and symptoms are definitely alleviated even with relatively small radiation doses, similar to the therapy employing strontium.

Adenocarcinoma↗
PubMed1979

The immune response of the mouse to lymphocytic choriomeningitis virus. I. Circulating antibodies.

A search was made in LCM virus-immune mice for virus-specific antibodies. With the help of an L-cell plaque assay, neutralizing antibody was readily detected. There were no essential differences between mouse strains, but marked differences existed between virus strains. Whereas the inoculation of either large or small doses of WE strain virus led to the early production of considerable concentrations of neutralizing antibody, in the case of E-350 strain virus, high doses were required and a much longer time interval had to elapse before the threshold of detection was attained. In addition to neutralizing antibody, LCM virus-infected mice produced sensitizing antibody (detected by the enhancing effect of an anti-mouse Ig antiserum on the ability of a serum to reduce virus infectivity) and complement-fixing antibody. Previous failures to detect neutralizing antibody in LCM virus-immune mice might have been caused by properties of the chosen virus, but in many instances lack of a suitable assay host is a more likely explanation.

Animals↗
PubMed1979

[An analytical method for calculation of electron dose distributions. Part II: Experimental verification and application in coplanar irradiation techniques (author's transl)].

The analytical method for calculation of electron dose distributions described in part I was experimentally verified using a 42-MeV betatron. For this, a comparison was made between the calculated and the measured dose distributions obtained with a homogeneous or inhomogeneous water or polystyrol phantom with plane or with uneven surfaces, the inhomogeneities consisting in cavities and cork intercalations. Thus, the accuracy of the algorithm and of the consideration for inhomogeneities and irregular surfaces is demonstrated, and limitations of the method's applicability are shown. Some examples of calculated dose distributions in coplanar irradiation techniques using solely electron beams or else a combined treatment with photons and electrons are exhibiting the particular bearing of electronic data processing on the treatment planning in depth therapy with electrons in the energy range above 20 MeV.

Computers↗
PubMed1979

[An analytical method to calculate electron dose distributions. Part I: Method (author's transl)].

A method for the calculation of electron dose distributions is described. The dose distributions of stationary electron beams in water are represented by formulas for depth dose curves and transverse distributions. Curved surfaces, oblique incidence of rays, and inhomogeneities are taken into account by applying the law of distance and the method of equivalent thicknesses of water layers. A detailed program is given to calculate the electron dose distributions in that plane of the central ray which is at right angle to the theoretical circle plane of a 42 MeV betatron.

Electrons↗
PubMedDate not supplied

[Scintigraphic diagnosis of neuroblastoma using meta-iodobenzylguanidine].

In 1979/80 meta-iodobenzylguanidine (MIBG) was introduced as a radiopharmaceutical agent with high affinity to the adrenal medulla. It could be shown, that scintigraphic imaging with 131J labeled MIBG is a sensitive and highly specific method for localization of pheochromocytoma. In this connection we could demonstrate in 1983 that neuroblastoma can be visualized scintigraphically with MIBG as well. Until now 13 patients were examined with 131J-MIBG by our group: In 10 children with histologically proven neuroblastoma we found a specific enrichment in the tumor area. Besides the primary tumor local recurrence and metastases to bones, bone marrow and brain were detected. There was no neuroblastoma manifestation without MIBG uptake. In 3 patients with tumors other than neuroblastoma no uptake of MIBG was noticed. The results agree with those of other studies: If the physiological pattern of distribution is taken into consideration and if the proper imaging technique is adapted, 131J-MIBG scintigraphy is a highly sensitive and specific method for staging, monitoring of disease and follow-up of neuroblastoma.

3-Iodobenzylguanidine↗
PubMedDate not supplied

MRI and MRA in treatment planning of subdiaphragmatic radiation therapy.

Radiotherapy treatment planning needs optimum definition of target volume in its relative position to normal tissue. The aim of our study was to achieve individual field definition in subdiaphragmatic radiotherapy by visualization of the target volume using fast, breath-held MRI and MR angiography. A modified rapid acquisition SE technique (SE 150/10) was used to obtain a coronal image within a 14 s breath-holding period, displaying kidneys, spleen, and lumbar spine on one slice. Coronal MR angiography acquisition in breath-hold technique was performed using a sequential FLASH-2D sequence (FLASH-2D 30/10/30 degrees). For reconstruction of the MR angiogram in coronal view, we used a maximum intensity projection algorithm. A computer program superimposed the MR angiogram onto the MR image. Correct magnification of the superposition image allowed direct projection onto the simulation film. Problems of distortion and different projection techniques were taken into account and quantified by phantom measurements. The localization error measured in a reference plane was less than 5 mm within a radius of 140 mm. Fourteen cases of Hodgkin disease and non-Hodgkin lymphomas were treated employing the novel technique. By superposition of the MR image and the MR angiogram, demarcation of vascular architecture from parenchymatous organs was achieved. Projection of the MR superposition onto the simulation film yielded accurate and convenient field definition using noninvasive imaging techniques.

Abdomen↗
PubMedDate not supplied

Identification of intracardiac thrombi in stroke patients with indium-111 platelet scintigraphy.

Platelet scintigraphy (PSC) with indium-111 labelled platelets has been confirmed as an adequate method for the detection of intracardiac thrombi in patients with heart disease. We performed PSC of the heart and the neck vessels in 27 stroke patients with suspected cardiac embolism and as control on 10 patients with atherosclerotic lesions of the carotid arteries without evidence of heart disease. The carotid PSC was positive in 6 of 10 patients with carotid disease, and twice in the 27 with suspected cardiac embolism. In these 27 the PSC of the heart indicated pathological conditions 13 times. Pathological platelet accumulations could be visualized in 3 cases in the atrial space, in 9 cases in the region of the left ventricle, and once at the aortic valve. Scintigraphy was negative in all 10 patients with atherosclerosis of the neck vessels. The two-dimensional echocardiography revealed pathological findings in 8 of the 13 patients with positive heart PSC (3 with intraventricular thrombi, 3 with valvular disease, 2 with decreased ventricular contractility) and was normal in the 10 control patients. Open-heart surgery was performed in 2 patients with pathological PSC and revealed an intracardiac thrombus. Three of 4 patients with positive atrial PSC showed mitral or aortic valve disease. These results suggest that PSC can provide a valuable method for detecting cardiac thrombi in stroke patients.

Blood Platelets↗