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Biomedical subjects

B Kiersnowska-Rogowska

Publications and source records attributed to B Kiersnowska-Rogowska.

At least 19 recordsLinked to original sources
PubMed1998

[Cytokines in acute myeloid leukemia].

The cytokines belong to the group of main factors regulating of leukaemia cell proliferation. Most of information comprised in the literature concern the behaviour of single cytokines in the cell culture in vitro. In the organism of leukaemia patient many different cytokines, adhesion molecules, growth factors and other substances probably act in the same time. Therefore the aim of study was the determination of plasma concentrations of interleukin 1B, 3, 4, 6, 8, G-CSF and P-selection in 26 patients with acute myeloblastic leukaemia-aml, among them 14 patient in the course of exacerbation-aml-e and 12 being in the remission-aml-r, classified as type M1 and M2 according to the FAB classification. Control group consisted of 15 healthy volunteers. The cytokine measurements were performed by means of immunoradiometric, immunoenzymatic and radioimmunologic kits. In the patients with aml-e significant increase of plasma concentrations of IL-1B, IL-3, IL-6, G-CSF, P-selectin and essential decrease of IL-4 was found. Significant decrease of IL-4 and P-selecting concentrations in the patients with aml-r and lack of changes in IL-8 concentrations in the both groups of patients was demonstrated. The observed differences of concentrations may additionally confirm the role of studied cytokines and P-selectin in the regulation of leukaemia cell proliferation.

Acute Disease↗
PubMed1997

[The role of some cytokines in the physiology of proliferation of hematopoietic cells].

Cytokines are of great importance in the regulation of proliferation of haematopoietic system cells. Most of known cytokines stimulate the proliferation of cells of granulocyte-macrophage, monocyte, and lymphocyte system. Some of them stimulate the proliferation of cells from erythrocyte, eosinophil and megakaryocyte systems and proliferation of B and T lymphocytes.

Cytokines↗
PubMed1997

[Cytokines in certain proliferative diseases of the hematopoietic system].

Some cytokines playing a great role in the proliferation of neoplastic haematopoietic system cells were described. Most of cytokines stimulate the cell proliferation in non-lymphoblastic leukemia, less of them act in lymphocytic leukemia and least in the other proliferative diseases of haematopoietic system.

Cytokines↗
PubMed1996

[Examination of interleukin levels and growth factor from blood platelets in leukemia].

Plasma concentrations of interleukines 1, 3, 6, 8 and platelet derived growth factor (PDGF) were estimated in 45 patients with leukaemias. Among patients were 12 with acute myeloblastic leukaemia-AML (type M1 according to FAB classification), 9 with chronic granulocytic leukaemia-CGL, 10 with blastic crisis of CGL (CGL-BC) and 14 with chronic lymphocytic leukaemia-CLL (in 1 and 2 stage according to Rai classification). Additionally the concentration of IL-3 was measured in 10 patients with exacerbation of CLL. Control group consisted of 12 health volunteers. The concentrations of interleukines and PDGF were determined by means of radioimmunoassay or immunoradiometric assay. In the patients with AML, CGL-BC and CLL significant increase of concentrations of IL-1B, IL-6 were found. The patients suffers from CGL and CGL-BC had increase concentrations of IL-3, but patients with CLL-interleukin 8. The concentrations of PDGF were significantly decreased in the patients with AML, CGL-BC, and CGL. The differences of concentrations of studied interleukines can confirm their great significance in proliferation of leukaemic cells. The decrease of concentrations of PDGF in myelocytic leukaemias may reflect thrombopoietic disturbances in these illnesses.

Blood Platelets↗
PubMed1986

Clinical investigations on long-term activation of fibrinolysis by anabolic steroids.

The influence of anabolic steroids plus phenformin on the course of disease was studied in patients suffering from occlusive vascular diseases. In arteriosclerosis obliterans of the lower limbs the combined therapy led to a higher percentage of improvement than the control group showed. In coronary heart disease there was also a beneficial effect of this treatment. The drugs were found to exert beneficial clinical effects especially in patients with thrombophlebitis migrans and superficial thrombophlebitis. From the results of this study it is concluded that this therapy may be of clinical value in the treatment of patients with occlusive vascular diseases.

Adult↗
PubMed1979

The effect of O-betahydroxyethyl-rutosides (HR) on the number of platelet-leukocyte aggregates in patients with occlusive arterial disease.

The diagnostic value and the effect of the therapy on the number and kind of platelet-leukocyte aggregates in 68 patients with arteriosclerosis obliterans of the lower limbs were investigated. The modified SILBERGLEIT'S method was used. 8 types of aggregates were found. The means number of aggregates in 20 healthy subjects was 8.2 but in 46 patients suffering from obliterative arteriosclerosis of the lower limbs this number was significantly higher, i.e. about 62. A significant decrease in the number of platelet-leukocyte aggregates in the group of 14 patients receiving HR orally 1800 mg daily and 16 patients receiving HR intravenously 2000 mg daily was found. In 16 persons a lower HR dose (orally 900 mg daily and intravenously 500 mg daily) did not influence the number of rosettes. In 22 patients receiving nicotinic acid (orally 900 mg daily, intramuscularly 600 mg daily) no significant changes in the number of rosettes was observed.

Administration, Oral↗
PubMed1978

N-acetyl-neuraminic acid (NANA) serum level in the diagnostics of preleukemic states, acute micromyeloblastic leukemias and pancytopenias.

The levels of N-acetyl-neuraminic acid were determined in patients with preleukemic states, acute micromyeloblastic leukemias and pancytopenias. A statistically significant increase of NANA was found in patients with micromyeloblastic leukemia in comparison with preleukemic states and pancytopenias. A significant rise in the NANA level was observed in preleukemic states in comparison with pancytopenia of other origins. The assay of the NANA level may be employed as a sensitive biochemical test for differential diagnostics of these diseases.

Diagnosis, Differential↗