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Biomedical subjects

B Kennes

Publications and source records attributed to B Kennes.

At least 55 records · Page 3Linked to original sources
PubMed1980

Human lymphocyte affinity for sheep erythrocytes in young and aged healthy subjects.

The kinetics of sheep erythrocyte rosette formation by human peripheral blood lymphocytes from young-adult and aged individuals were studied in 20 paired experiments. No difference in the rate and saturation plateau of formation could be found despite a slight increase in early rosette-forming cells. We conclude that the membrane affinity for sheep erythrocytes is unaffected by ageing and that the proportion of the circulating early E-RFC subpopulation is increased in healthy older subjects.

Adult↗
PubMed1977

Treatment of chronic urticaria with a beta2-adrenergic stimulant.

Twenty-four patients with chronic utricaria resistant to conventional therapy were treated orally with terbutaline, a specific beta2 stimulant. This therapy was much more effective than antihistamines. At the dose of 1-25 mg three times a day, there were few side effects. The efficacy was independent of the IgE levels; it seemed greater in idiopathic cases than in cholinergic or pressure induced urticaria.

Adolescent↗
PubMed1977

IgE mediated hypersensitivity in ageing.

The serum IgE concentration is significantly lower in aged as compared with young people. This is more pronounced in males than in females (P less than 0-05). In fifteen aged (greater than 70 years) compared with fifteen young subjects (less than 40) the specific IgE antibody response to an injection of diphtheria toxoid was significantly reduced (P less than 0-01). The minimum concentration of anti-IgE antibody able to induce a weal and flare reaction when injected intradermally, was comparable in the two age groups. However, the diameter of the weal reaction was significantly reduced in the aged. It is concluded that the reduced incidence of atopic symptoms in old people might be secondary to an anomaly of both the immune system and the mast cells.

Adult↗
PubMed1977

Influence of levamisole on the immune response of old people.

Fifteen healthy people, over 70 years old, have been treated during 1 month with Levamisole at the dose of 150 mg a day, twice a week. They have been compared to 15 controls matched for age and sex. At the start of the study, each subject was injected with 0.2 ml of a diphtheria-tetanus vaccine. Levamisole had no effect on the following immune parameters known to be altered in old age: serum IgE concentration, specific IgE and IgG antibody response to diphtheria toxin, lymphocyte response to phytohemagglutinin (PHA). There was a slight and transitory effect of Levamisole on the isohemagglutinin titer. In vitro, Levamisole was weakly mitogenic for the peripheral blood lymphocytes from old and young control subjects but there was no influence on the response to PHA.

Aged↗
PubMed1976

In vitro response of subpopulations of human lymphocytes. II. DNA synthesis induced by anti-immunoglobulin antibodies.

A significant and constant increase in DNA synthesis was observed in human lymphocytes cultured in the presence of purified anti-immunoglobulin antibodies specific for human IgG, IgA, and IgM. This has been found in cultures of lymphocytes isolated from blood, tonsils, spleen, and lymph nodes. The optimal culture conditions for blood and tonsil lymphocytes were determined. As a rule 6-day cultures containing 2 x 10(6) cells/ml and 100 mug/ml of antibody yielded the highest 3H-thymidine uptake. Purified T cell cultures could not be stimulated, whereas a low response could be observed in most of the purified B cell cultures. Optimal culture conditions were the same for the B and total tonsil lymphocytes. However, when the purified B cells were totally depleted of T cells, no response was observed. A T and B cell synergy has been demonstrated by supplementing B cell cultures with purified T cells, whether treated or not with mitomycin. These experiments indicated a permissive and potentiating effect of T cells on the B cell response. Cultures containing mitomycin-treated B cells and purified T cells (mB + T) could be stimulated by a-Ig, thus indicating a T cell proliferation. In keeping with this finding was the observation of an increased response of total lymphocytes supplemented with T cells but not with B cells. Adherent cells are necessary for an optimal response to a-Ig; they enhanced the B cell proliferation observed in (Tm + B) cultures and suppressed the response of T cells in (T + Bm) cultures.

Antibodies, Anti-Idiotypic↗
PubMedDate not supplied

Stability of E-rosettes in aged humans: effect of cytochalasin B and colchicine.

A greater stability of E-rosettes and a reduced rate of capping of sheep erythrocytes are observed in elderly people. The lack of qualitative changes in the sensitivity of these processes to colchicine and cytochalasin B suggests that the function of the microfilaments and the microtubules is not primarily affected by ageing. The density and the affinity of the lymphocytes for sheep erythrocytes do not decrease in aged subjects. So the defective rearrangement of the E-receptors cannot be accounted for by some receptor alteration but points to a possible hindrance of their cross-linking in the membrane or their submembrane connection to the cytoskeleton.

Aging↗