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Biomedical subjects

B Kennedy

Publications and source records attributed to B Kennedy.

At least 127 records · Page 7Linked to original sources
PubMed1985

Nutrition support of inborn errors of amino acid metabolism.

Programs for nutrition support of patients with phenylketonuria, maternal phenylketonuria, branched chain ketoaciduria and vitamin B-6 non-responsive homocystinuria were written in BASIC. These programs plan diets to fill diet prescriptions using natural foods, available amino acid-free or restricted elemental products, milk or infant proprietary formulae and protein-free fat and carbohydrate sources. Emphasis is placed on satisfying the amino acid and protein prescriptions simultaneously. The final semisynthetic formula is evaluated for vitamins, minerals, renal solute load and renal net acid excretion. Fluid requirement is estimated. The paper describes how the conventional protocols are enhanced by computerization and details the requisite calculations.

Amino Acid Metabolism, Inborn Errors↗
PubMed1985

Effects of physostigmine on pulse, blood pressure, and serum epinephrine levels.

In this study, the infusion of physostigmine in 14 patients with affective disorder who were pretreated with methscopolamine caused significant and often profound increases in the patients' epinephrine levels, pulse rates, and blood pressure. Since physostigmine is being used experimentally in the treatment of elderly subjects who have Alzheimer's disease, these cardiovascular effects may have clinical importance.

Adult↗
PubMed1985

Residential treatment of adolescents: a treatment model.

This paper outlines a residential treatment model for adolescents. An essential component of this model is its emphasis on rehabilitation. Thus, community involvement and, therefore, treatment within the community is a cornerstone of patient management. The model is currently operating with emotionally disturbed adolescents, some with concurrent chronic medical disabilities. Research protocol, evaluating its effectiveness, is in place and will be documented in a future paper.

Adolescent↗
PubMed1985

Efficacy and field evaluation of Bacillus thuringiensis (H-14) and B. sphaericus against floodwater mosquitoes in California.

The microbial control agents Bacillus thuringiensis (H-14) and B. sphaericus were evaluated in laboratory and field against Psorophora columbiae. Bacillus sphaericus strain 2362 was also tested in the field against Aedes melanimon. Psorophora columbiae was slightly more susceptible than Culex quinquefasciatus to active strains of B. sphaericus. The LC90 for active strains ranged from 0.013 to 0.069 mg/liter. In field trials, aqueous suspensions of primary powder of B. sphaericus 2362 and 1593 yielded 98-99% reduction in larvae at the rates of 0.1 to 0.25 lb/acre of the primary powder. Granular formulations of Bt (H-14) were evaluated against Ps. columbiae, yielding 96-99% control of larvae at rates ranging from 1 to 10 lb/acre of the granules, depending on the potency and type of the formulations. Aedes melanimon was slightly less susceptible than Ps. columbiae to B. sphaericus 2362. In warmer water a rate of 0.25 lb/acre of the primary powder yielded 88% control, while this same rate in cool weather yielded only 4% reduction. A rate of 0.5 lb/acre of the primary powder was needed to obtain 94% control of larvae in cool weather.

Animals↗
PubMed1985

The effects of dopamine agonists on human cardiovascular and sympathetic nervous systems.

We gave people four different dopamine agonists and monitored blood pressure, heart rate and circulating catecholamine levels. Bromocriptine decreased blood pressure and plasma norepinephrine levels. Dopamine increased pulse pressure, heart rate and circulating epinephrine (E) and norepinephrine (NE) levels. Dopamine agonists tend to diminish blood pressure by inhibiting sympathetic neuronal discharge of NE and, to a lesser extent, by stimulating dopamine vascular receptors. However, dopamine and L-dopa can be converted to NE and E, both of which have pressor effects. The complex cardiovascular effects of dopamine agonists are the result of stimulation of dopamine vascular and neuronal receptors and the production of NE and E.

Adult↗
PubMed1985

Laboratory and field evaluation of the IGR fenoxycarb against mosquitoes.

A new juvenile hormone mimic [fenoxycarb or RO13-5223 ethyl-(p-phenoxyphenoxy) ethylcarbamate] was evaluated in the field against Culex tarsalis in stagnant water ponds, Psorophora columbiae and Aedes melanimon in irrigated pastures. This material, showing high level of activity against Cx. quinquefasciatus in laboratory, was found to be highly effective against field populations of the 3 former species. A 5% attaclay granular formation yielded 100% inhibition of emergence in Cx. tarsalis at the rate of 0.1 lb/acre ai, 2 days after treatment. The extent of control declined markedly 7 days after treatment. An EC and 1% sand coated granular formulation yielded poor control providing 91 and 69% inhibition of emergence 2 days posttreatment at the high rate of 0.25 lb/acre ai. The 2 flood water mosquitoes were about 10 X more susceptible than Cx. tarsalis. The EC and 1% attaclay granular formulations produced 100% inhibition of emergence of the floodwater mosquitoes Ps. columbiae and Ae. melanimon in irrigated pastures at the rate of 0.01 lb/acre ai, while Cx. tarsalis required 0.1 lb/acre ai for this level of EI. Most of the mortality in treatments with this insect growth regulator was noted in the pupal stage, very few dying in the larval stage or as adults upon emergence. From extensive field studies, it can be concluded that fenoxycarb has excellent potential in operational mosquito control programs.

Animals↗
PubMed1985

Computer-implemented nutrition support of phenylketonuria.

This project demonstrates that computers can fill diet prescriptions for nutrition support but only if nutritionists who know how to fill diet prescriptions do the programming. The computer can provide information that is required to improve nutrition support, as well as save time that the dietitian can use in patient education. The computer, however, cannot replace the dietitian. It merely performs mathematical calculations. Establishment of the diet prescription, choice of products, and the use of the final formula and foods require trained judgment used in conjunction with appropriate clinical and laboratory data.

Dietetics↗
PubMed1984

Central cholinergic stimulation causes adrenal epinephrine release.

Cholinergic drugs administered into the cerebral ventricles of animals selectively stimulate the adrenal medulla. However, the effects of central cholinergic stimulation on the sympathoadrenal system have not been studied in man. We stimulated central cholinergic activity in man by administering the cholinesterase inhibitor physostigmine to subjects pretreated with peripheral cholinergic blocking agents. A dose of 0.022 mg/kg physostigmine dramatically increased plasma epinephrine levels and slightly increased norepinephrine levels, which is consistent with selective adrenomedullary stimulation. A smaller dose of physostigmine increased epinephrine but did not alter norepinephrine levels. Subjects had increased pulse rates and blood pressures, and felt anxious while they had high plasma epinephrine levels.

Adrenal Medulla↗
PubMed1984

A cholinomimetic model of motion sickness and space adaptation syndrome.

The space adaptation syndrome is one of the more vexing problems confronted by our nation's astronauts during their journeys. This syndrome may be a variant of motion sickness, although this possibility has been questioned. Physostigmine, a centrally active cholinesterase inhibitor which increases brain acetylcholine, was found to cause a motion sickness-like syndrome--in psychiatric patients and normals--including nausea, emesis, malaise, dysphoria, increases in serum ACTH, beta-endorphin, cortisol, and prolactin, Neostigmine, a non-centrally acting cholinesterase inhibitor, and saline placebo caused no such effects. The above effects closely parallel those of motion sickness. Thus, the effects of physostigmine may be a convenient model for screening for treatments for motion sickness or space adaptation syndrome, or for predicting who will develop these syndromes.

Adaptation, Physiological↗
PubMed1983

Primary structure of protamine from the Northern pike Esox lucius.

The basic nuclear protein in the sperm of the Northern pike is a protamine, 32-residues long, which behaved as a single component during ion-exchange chromatography and gel electrophoresis. Amino acid analysis gave close to molar ratios for the eight different residues with no evidence of microheterogeneity. However, the presence of sequence variants was revealed following a combination of automated protein sequencing and cleavage of the protamine by CNBr, endoproteinase Lys-C and thermolysin. At position 28 there is an equal probability of having serine or glycine. At position 9 glycine is found more frequently than serine. The reciprocal nature of the substitutions results in glycine and serine contents which are close to a 4:2 ratio. Pike protamines are homologous to those of the trout but show less sequence variation between components.

Amino Acid Sequence↗
PubMed1982

Platelet-derived growth factor. Specific binding to target cells.

The binding of the human platelet-derived growth factor (PDGF) to Swiss mouse 3T3 cells have been investigated. The binding is specific and reversible. The dissociation constant is approximately 0.7 x 10(-9) M with approximately 400,000 binding sites/cell. Two forms of PDGF, PDGF I (Mr = 31,000) and PDGF II (Mr = 28,000), previously identified (Deuel, T. F., Huang, J. S., Proffitt, R. T., Baenziger, J. U., Chang, D., and Kennedy, B. B. (1981) J. Biol. Chem. 256, 8896-8899 and Deuel, T. F., Huang. J. S., Proffitt, R. T., Chang, D., and Kennedy, B. B. (1981) J. Supramol. Cell Biochem. 5 (Suppl.), 128) bind equally well to 3T3 cells. Polylysine and histone, but not cytochrome c, partially inhibit the binding of PDGF to 3T3 cells. Protamine sulfate blocks binding in a competitive manner and is capable of displacing PDGF previously bound to the cell surface. EDTA influenced neither the binding of PDGF to the cell surface nor the displacement of cell-bound PDGF. At 37 degrees C, PDGF bound to the cell surface is lost and iodotyrosine is released free into the supernatant, with each process having a t 1/2 of approximately 90 min. The binding activity of the putative PDGF receptor is markedly reduced by previous incubation with PDGF, thereby apparently regulating its activity in a manner similar to epidermal growth factor.

Animals↗
PubMed1981

Self-medication.

Explore the source record for details and available documents.

Diuretics↗
PubMed1977

Gait rehabilitation for an arm amputee.

This report is concerned with a male motor bike rider who was injured in a collision with a semi-trailer in June 1974. As a result of his injuries he had his right arm amputated, his right knee restricted, and his right foot partially amputated and pinned. This article presents the subsequent management of the patient which was aimed at achieving an acceptable foot and preventing further breakdown in other body linkages. The design of appliances and treatment were carried out by the physiotherapist, the chiropodist, and the bioengineer.

Amputees↗