[Sympathetic ophthalmia: current clinical data apropos of 3 cases].
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Biomedical subjects
Publications and source records attributed to B Kantelip.
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We studied the blood mononuclear cells in a seventy-four-year old man who had urinary tract malacoplakia located to bladder, ureter and kidney. The blood mononuclear cells were isolated as described by Boyum [2] and studied by electron microscopy. They did not show bacilliform bodies or bacteria in the phagolysosomes. The microfilaments and the microtubules were not easily identifiable in the mononuclear cells of the patient. In the control, the internal skeleton of the mononuclear cells was normal. This ultrastructural finding may suggest that there is a relation between microfilaments and microtubules lesion and the low level of cyclic G.M.P. described by Abdou et al.
The case of a patient with a uterine tumor resembling an ovarian sex cord tumor is reported. This tumor is designated, according to the features described by Clement and Scully, as group II. The predominantly tubular pattern and the lipid-rich cells created an appearance indistinguishable from that of an ovarian Sertoli cell tumor. Ultrastructurally, a structure that resembled a Charcot-Böttcher crystal was observed. From this observation, it is hypothesized that the neoplastic cells showed Sertoli cell differentiation.
The case of a patient with an intracardiac ectopic thyroid is reported. A lesion was found in a 25-year-old man and was diagnosed by two-dimensional echocardiography as a right intraventricular tumor. An operation was performed. Histologic and ultrastructural studies showed that the tumor was a thyroid mass. The origin of intracardiac ectopic thyroids is probably to be found in disturbances occurring early in embryogenesis.
The rabbit defense system has a number of specific features: no lactoferrin and lysozyme are detectable and peroxidase activity is only demonstrated in the cubic epithelial cells of the ducts. Experiments carried out with radioactive amino acid, demonstrate the absence of secreted proteins with molecular weights corresponding to those of albumin and transferrin, indicating that these proteins are not synthesized by the lacrimal gland tissue. Rabbit tear pattern presents a set of acidic proteins secreted by the lacrimal gland tissue, with small molecular weight and acidic pI's.
A search for an allergic cause in asthma is fundamental to the diagnosis. Typically it is based on: A clinical history. Specific cutaneous and inhaled provocation tests which can produce a possible reaction (early and delayed) which are of great pathophysiological and therapeutic interest. In vitro tests (which enable the different phases of the allergic reaction to be distinguished) to know the serum IgE antibody levels (total IgE, specific IgE and their fixation to cell receptors) cell tests on the degranulation of basophils and the dosage of chemical mediators: histamine, leukotrienes, prostaglandins, P.A.F. in the serum or in the bronchial alveolar lavage liquid, from the study of cells or tissue samples. In this regard the authors stress two recent techniques enabling direct access to bronchial tissue and the pulmonary parenchyma, which are bronchoalveolar lavage and bronchial biopsy, both are possible today by using a fibroscope. The broncho-alveolar lavage still remains in the research area, and is not always well tolerated in asthmatics. It already allows a better definition of the major allergic cytological and biochemical components in asthma (IgE, IgA, albumin, phospholipids, mast cells and eosinophils). Bronchial biopsies with ultra-structural studies, and above all immunopathology (by immunofluorescent techniques and peroxidase stains) enable groups of asthmatics to be uncovered who were considered as non-allergic by the unsuspected intervention of hypersensitivity mechanisms to IgE (the presence of cells carrying IgE); these biopsies enable the importance of inflammatory factors to be confirmed and equally to establish the prognosis in certain asthmatics by the degree of irreversibility of the lesions (fibronectin).(ABSTRACT TRUNCATED AT 250 WORDS)
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A case of Tangier disease with results of histological and ultrastructural studies is reported. The clinical, biological and histological picture was typical, with enlarged liver and spleen, voluminous tonsils, low blood levels of alpha-lipoproteins and cholesterol and high blood levels of triglycerides. The histological study revealed widespread tissue storage of cholesterol esters in the Mononuclear Phagocyte System. Lipid deposits were located in foamy histiocytes by staining with lipid-specific stains. The ultrastructural study revealed intracytoplasmic vacuoles unbounded by membranes and often confluent. Unlike other previously described cases, this one had a rapid fatal outcome.
Intravascular bronchioloalveolar tumor is a rare tumour of the lung. Having observed a case detected during systematic examination in a 44-year old woman, the authors compare the radiological, clinical, histological and evolutive signs of the disease with those reported in the 40 cases published since the first description by Dail and Liebow, in 1975.
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Double perforating injuries and linear wounds were produced in the posterior segment of the rabbit eye in order to study post-traumatic intraocular proliferation. After observation for one month, the animals were sacrificed and the eyes treated for histologic examination. Transvitreous strands and preretinal membranes slowly developed, sometimes inducing traction retinal detachment. Histologic studies demonstrated the new-formed tissue to be fibrovascular, mainly containing collagenous fibers and fibroblast-like cells. This fibroblastic proliferation closed the wound through the ocular membranes and invaded the vitreous using vitreous fibers as a scaffold. The authors discuss the signification of this results comparing them to literature data on different animals and on man.
The authors report 2 cases of hypersensitivity pneumopathy associated with haematological abnormalities: benign lymphoproliferative syndrome in one case, and malignant lymphadenopathy with fatal outcome in the other case. Such cases, now observed with increasing frequency, can be regarded either as chance associations of 2 types of disease, or as the results of immune disorders with repercussions on the blood.
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The authors discuss comprehensive observations on three cases of broncho-alveolar cell carcinoma covering different anatomo-clinical aspects. The first case was diffuse and characterised radiologically by soft nodular shadows bilaterally, the second had lobar opacities and in the third the tumour was locally limited. Histological study showed two cellular types, in variable proportion according to the case, namely 1. mucus cells and 2. cells containing rounded osmiophilic secretory granules, identified on ultra-structure as Clara cells. In the diffuse form mucus cells predominated. They were absent in the third case where the tumour consisted solely of Clara cells. Thus, the Clara cell seemed to be the characteristic cell of alveolar cell carcinoma. Alveolar cell carcinoma can be diagnosed today by fibre-optic bronchoscopy with transbronchial biopsy and it is fundamental to arrive at a precise cellular diagnosis, which can only be achieved by ultra-structural studies.
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