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Biomedical subjects

B Kaada

Publications and source records attributed to B Kaada.

At least 55 records · Page 3Linked to original sources
PubMed1984

Systemic sclerosis: successful treatment of ulcerations, pain, Raynaud's phenomenon, calcinosis, and dysphagia by transcutaneous nerve stimulation. A case report.

Transcutaneous nerve stimulation (TNS) has previously been shown to improve microcirculation in ischemic limbs of patients with Raynaud's phenomenon and diabetic neuropathy and to accelerate healing of chronic skin ulcerations. The present report deals with a patient with systemic sclerosis in which Raynaud's phenomenon, ulcerations and pains in the feet, calcinosis and dysphagia have been successfully treated by TNS. The mechanisms implicated are discussed.

Calcinosis↗
PubMed1983

In search of mediators of skin vasodilation induced by transcutaneous nerve stimulation: I. Failure to block the response by antagonists of endogenous vasodilators.

Low-frequency transcutaneous nerve stimulation (TNS) produces marked and widespread increases in skin temperature in ischaemic limbs of patients with Raynaud's disease and diabetic polyneuropathy. The prolonged time course of the temperature rise, which is due to increased cutaneous microcirculation, indicates the involvement of a long-lasting neurohumoral substance or metabolite. The vascular response is insensitive to conventional low doses of naloxone (Kaada, 1982a). In the present study the possible release of known endogenous vasodilators, all operating through the sympathetic nerves (Fig. 1, Nos 2-8), have been tested in patients by employing selective pharmacological antagonists or inhibitors to see if the stimulation-induced vasodilation could be blocked. The response was not antagonised either by beta-adrenergic, cholinergic, histaminergic, purinergic, or dopaminergic antagonists or by inhibitors of prostaglandins or plasma kinins.

Adult↗
PubMed1983

In search of mediators of skin vasodilation induced by transcutaneous nerve stimulation: II. Serotonin implicated.

Previous studies have shown that brain serotonin is increased and noradrenaline decreased in acupuncture and transcutaneous nerve stimulation (TNS). Increases in available brain serotonin and decreases in noradrenaline enhance pain suppression. The present study tests the possibility that the widespread and prolonged cutaneous vasodilation which can be produced by low-frequency TNS in patients with peripheral circulatory insufficiency is similarly dependent on a central serotonergic pathway leading to sympatho-inhibition. The serotonin receptor antagonist cyproheptadine was given to 4 patients with either Raynaud's phenomenon or diabetic polyneuropathy, who all prior to drug administration responded to TNS with marked and prolonged cutaneous vasodilation in the ischaemic limbs. Cyproheptadine almost completely blocked the vascular response. Contrary to endorphin-serotonin mediated pain inhibition, vasoconstrictor inhibition is not antagonized by conventional, low doses of naloxone (Kaada, 1982a). However, the involvement of more naloxone-resistant opioid receptors in the vascular response cannot be excluded.

Adult↗
PubMed1981

Enuresis and hyperventilation response in the EEG.

A total of 420 enuretic children aged between four and 15 years and 100 controls were examined by EEG in order to determine their hyperventilation response, which is considered to be a non-specific sign of brain dysfunction or of cortical instability as a result of delayed maturation. It was found that an increased hyperventilation response occurred mainly among children with primary enuresis (bed-wetters from birth). This was true even if the children had a 'uropathy'. It was also commoner among the children with pathological EEGs at rest. The results for those with secondary enuresis (later onset) were similar to the controls. These findings indicate that disturbed cerebral control of the bladder is an important factor in primary enuresis. Psychological factors are thought to account for the occurrence of secondary enuresis.

Adolescent↗
PubMed1975

Locomotor, avoidance and maze behavior in rats with the dorsal fornix transected.

Transection of the dorsal fornix bundle in rats resulted in impaired maze learning, while the behavior in open field, passive avoidance and spontaneous alternation test was unchanged. The results are discussed in terms of an association deficit. It is concluded that the dorsal fornix is probably not to be regarded as part of the hippocampal output system.

Animals↗