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Biomedical subjects

B K Patnaik

Publications and source records attributed to B K Patnaik.

At least 91 records · Page 5Linked to original sources
PubMed1967

Evaluation of microscopic methods in the diagnosis of idiopathic steatorrhoea.

Of 14 cases of clinically and biochemically confirmed idiopathic steatorrhoea, 11 showed mucosal abnormalities when biopsy specimens from the upper small intestine were examined under the dissecting, the light, and the electron microscope. In the three remaining cases mucosal changes could be detected only under the electron microscope. The simple and inexpensive dissecting microscope can therefore be accepted as an efficient instrument for routine use in the diagnosis of idiopathic steatorrhoea and for the screening of cases which might merit further examination under the electron microscope. The light microscope allows the heights of the villi and the depth of the glandular layer to be measured and the limits of normality to be defined on a quantitative basis.The electron microscope reveals abnormalities in the microvilli of mucosal epithelial cells. The mildest changes consist of shortening and fusion of the microvilli and a lessened electron-density of the apical cytoplasm. Since these changes occur in mucosae which appear to be normal under the dissecting and the light microscope they are assumed to be related to the earlier stages of the disease and their significance is discussed in the light of this view.

Celiac Disease↗
PubMed1966

Metabolic changes in the skin of rats of various ages. Oxygen consumption and uptake of glucose.

1. Parallel determinations of the oxygen consumption by skin slices with glucose or galactose as substrate and of the concentration of DNA of the skin of various ages of rats were carried out to study the metabolic changes of the skin with age. 2. Both the oxygen consumption and the DNA content of the skin decreased rapidly till the attainment of maturity; thereafter the rate of decrease in oxygen consumption was lower whereas the concentration of DNA was constant. The decrease in the oxygen consumption during the early developmental period is thus due to the loss of cells, but the decrease in the older rats may be due to a decline in the activity of the cells of the skin as a result of aging. 3. The uptake of glucose by the skin decreased with increasing age.

Aging↗
PubMed1966

Ascorbic acid and aging in the rat. Uptake of ascorbic acid by teeth and concentration of various forms of ascorbic acid in different organs.

1. The uptake of ascorbic acid in vitro by the teeth of rats showed a gradual decrease with age, indicating that the uptake may be related to collagen synthesis as in bone. 2. The concentration of total free ascorbic acid in various organs declined with age, but the rate of decline was different in different organs. In the spleen, however, it increased until maturity and then declined. 3. This decrease may be due to one or both of the following reasons: (a) the permeability of different tissues may decrease at different rates for ascorbic acid, or (b) the requirement for ascorbic acid may decrease at different rates. 4. The bound ascorbic acid declined with age in the skin, kidney, liver and brain after the age of 10-12 weeks, and in the spleen after the age of 26 weeks. 5. The concentration of dehydroascorbic acid and dioxogulonic acid declined with age in the skin.

Aging↗
PubMedDate not supplied

Age-related changes in brain and spinal cord lipids of the male garden lizard.

The lipid composition (cholesterol, phospholipid triglyceride and fatty acids) of brain and spinal cord of the male garden lizard was traced during maturation and ageing. The total brain cholesterol content of both the tissues showed a significant rise during maturation, remaining almost constant thereafter. The free cholesterol content of the brain increased between middle and old age and that of the spinal cord increased during maturation. The esterified cholesterol content of the brain increased during maturation, the same parameter being not age-dependent in the spinal cord. While in the brain the phospholipid content increased during maturation followed by a decrease in old age, it showed a reverse trend in the spinal cord. The level of triglyceride in the brain declined during maturation followed by an increase in old age with no appreciable age change in the spinal cord. A comparison between young and old age-groups revealed a decrease in fatty acid content of the brain. A similar trend of decline was observed during maturation in the spinal cord. The pattern of age changes in the lipid profile of nervous tissue of the lizard, a non-mammalian vertebrate, almost conform to the pattern observed in a majority of mammals.

Journal Article↗
PubMedDate not supplied

Age-related changes in glucose uptake of cerebral hemisphere slices of male garden lizards in response to starvation stress.

In the male garden lizard, the glucose uptake of cerebral hemisphere slices did not change during maturation (young to middle-aged) but declined during ageing (middle-aged to old). Short-term starvation (3 days) did not cause a significant change in glucose uptake of cerebral hemisphere of young lizards but led to an increase in the parameter in both the middle-aged and old.

Journal Article↗