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Biomedical subjects

B K Maini

Publications and source records attributed to B K Maini.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

Pulmonary diffusion capacity for Co at varying alveolar oxygen tensions and different alveolar volumes.

In six healthy nonsmoker volunteers pulmonary diffusion capacity for Co (DLCO) was determined by single breath holding technique. Multiple measurements of DLCO were taken with PAO2 from 70 to 610 mm Hg, out of which at least 10 tests were performed between 100 to 140 mm Hg. A wide and non uniform inverse relationship was found between DLCO and PAO2 from 70 to 610 mm Hg. In narrow range of 100-140 mm Hg, a highly significant linear negative correlation was found. To find out corrected DLCO at PAO2 120 mm Hg, expressed as DLCO120, a correction factor of 0.45% for each mm Hg change in PAO2 should be applied to measured DLCO inversely. By regulating inspiratory volume, DLCO was studied at different alveolar volumes and there was a direct positive correlation between them. DLCO should be measured at maximum alveolar volume, as with one percent fall in VA there is 0.69% decrease in DLCO. This new method of expressing DLCO as DLCO120 at maximal effective alveolar volume will be more useful in studying the effects of factors affecting DLCO and for interlaboratory comparison.

Adult↗
PubMedDate not supplied

Amygdalar injections of vasopressin and its antagonist do not disrupt the circadian rhythm of food and water intake in the rat.

There is an indication that areas of the brain other than the suprachiasmatic nuclei (SCN), the known neural circadian pacemaker, are involved in the control of circadian rhythms. The present study investigated the role of amygdala in the circadian rhythms of food and water intake. Vasopressin and its antagonist d(CH2)5Tyr(Me)AVP were injected into the amygdala bilaterally through chronically implanted stainless steel cannulae. The results of the study have shown that neither vasopressin nor its antagonist d(CH2)5Tyr(Me)AVP alters the circadian rhythm of food and water intake thereby showing that vasopressinergic neurons/projections to amygdala are not involved in the control of circadian rhythms of food and water intake and amygdala is not likely to be an additional oscillator.

Amygdala↗
PubMedDate not supplied

Role of H-reflex latency studies in the diagnosis of subclinical diabetic neuropathy.

Motor conduction velocity (MCV) in the median, ulnar and peroneal nerves and H-reflex studies have been conducted in 50 diabetics aged 20-65 years and 25 controls. MCV in the upper limb was below the normal range in 16% of diabetics. 28% diabetics showed abnormal MCV in the peroneal nerve. H-reflex abnormality consisting of either prolonged latency or its complete absence could be observed in 54% of diabetics. The results indicate the greater sensitivity of H-reflex in the detection of sub-clinical diabetic neuropathy. Greater prevalence of neuropathy in the early onset diabetes than in the late onset type is also suggested.

Adult↗
PubMedDate not supplied

Comparative study of visual and auditory reaction time of hands and feet in males and females.

Simple reaction time of hands and feet was studied in normal subjects (47 males, and 17 females) to visual and auditory stimuli using an electric circuit and recording points of stimulus and action on a fast moving kymograph. There are significant differences between reaction times of hands and feet, right side and left side, males and females and between auditory and visual reaction times (ART and VRT). Both VRT and ART were significantly faster in hands. Delayed response of left side (LH and LF), was more marked in feet with ART. On crossing hands, both VRT and ART took more time in RH. Males responded faster than females, difference being significant mainly in ART and that too on left side. ART was slightly faster than VRT. Faster response of right side was probably due to the fact that all the subjects were right handed persons.

Adult↗
PubMedDate not supplied

Bilateral asymmetry in conduction velocity in the efferent fibres of the median nerve andits relationship to handedness.

The conduction velocity in the efferent fibres of the median nerve has been compared in the right and left forelimbs of 38 human subjects. Six independent estimates were made for each limb. Estimates on the right and left limb of a subject were made at the same sitting. Conduction velocity was faster on the right side in the majority of right handed subjects; and on the left side in the majority of left handed subjects. The mean conduction velocity was greater on the right side in right handed subjects (P less than 0.02).

Adolescent↗
PubMedDate not supplied

Peak expiratory flow rate and its prediction formulae in Haryanvis.

Peak expiratory flow rate (PEFR) was studied in 806 healthy 6 to 58 year old Haryanvi males. A steep rise in PEFR is seen with age up to 18 years, little variation occurs between 19 to 26 years and is followed by a gradual fall thereafter. The formulae for the prediction of PEFR from age and height in different age groups have been worked out. Haryanvi children are taller having PEFR and predicted values of PEFR higher than the children of other Indian states and are well comparable to Western children. On the other hand in Haryanvi adults observed and predicted values of PEFR are low. It is possible that economical uplift of this area due to industrialization and green revolution has led to improved nutrition resulting into better physical and functional (PEFR) development of younger generation. It is suggested that in developing states the physical and functional norms should be periodically reviewed.

Adolescent↗
PubMedDate not supplied

Pulmonary functions and their correlation with anthropomorphic parameters in young adults of Haryana (India).

Pulmonary functions in 169 young males of Haryana were studied with the help of a water seal spirometer and Wright's peak flow meter. Different parameters analysed were FVC, FEV1%, P.F.R., MVV, and expiratory flow rates between 25-50%, 25-75% and 50-75% of FVC. Our mean values are well comparable with those of Indian workers but less than those reported by Western workers. Pulmonary functions correlate better with physical parameters, height arm span and upper segment than with age. Correlation coefficient (r) values of FVC and anthropomorphic parameters are +0.7953, +0.3835, +0.3566 and +0.0992 with arm span, upper segment, height and age respectively. These values of pulmonary functions in healthy adults when compared with those obtained from patients suffering from chronic obstructive lung disease, it was observed that expiratory flow rates may be more useful in the detection of pulmonary changes in obstructive lung diseases at an early and reversible stage.

Adolescent↗
PubMedDate not supplied

Effect of isoprenaline and cigarette smoking on airways.

After two hours of abstinence from smoking pulmonary functions were assessed in twenty-seven asymptomatic male smokers by spirometry and Wright Peak Flow Meter, recording FVC, FEV1, FEV1%, FEF25-75%, and FEF75-85% of FVC, MVV and PEFR. These tests were repeated immediately after smoking and again after one hr. Only PEFR decreased significantly (P less than 0.01) and returned to nearly basal level after one hr. Sixteen of these smokers were subjected to further study. Isoprenaline inhalation in these smokers caused a significant improvement in most of the flow rates. Smoking of cigarettes at this stage decreased flow rates. After one hr the effect of smoking was over and most of the parameters were between basal and post-isoprenaline levels. Smoking affects the flow rates more than other parameters. An improvement in FEV1, FEV1%, FEF25-75% and FEF75-85% of FVC, after bronchodilator inhalation suggests the presence of some reversible bronchoconstriction specially of smaller airways basically present in chronic smokers.

Humans↗
PubMedDate not supplied

Seasonal variations in urinary calcium and sodium excretion.

Serum levels and urinary excretion of calcium, sodium and creatinine have been studied in 25 male subjects in summer and winter seasons. In contrast to the reports from the West, urinary calcium excretion was significantly less in summer than in winter. Urinary sodium excretion too was decreased in summer. The mechanisms possibly responsible for the observed seasonal variations have been discussed.

Adult↗