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Biomedical subjects

B Jennett

Publications and source records attributed to B Jennett.

At least 181 records · Page 10Linked to original sources
PubMed1974

Effect of carotid ligation on cerebral blood flow in baboons. 2. Response to hypoxia and haemorrhagic hypertension.

Cerebral blood flow (CBF) measurements were carried out in two groups of anaesthetized normocapnic baboons. In the first group of five animals the effect of hypoxia on the CBF before and after ipsilateral carotid artery ligation was studied. The results showed that, although after ipsilateral carotid ligation there was little change in the CBF at normal PaO(2), at hypoxia there was only 20% rise in the CBF as compared with an 80% rise before the carotid ligation. In the second group of 10 animals, effects of haemorrhagic hypotension on the CBF after ipsilateral carotid artery ligation were estimated. The results indicated impairment of autoregulatory response of the cerebral circulation.

Animals↗
PubMed1973

Ventriculoperitoneal shunting for hydrocephalus.

Revision rate and complications were reviewed in 297 patients of all ages subjected to ventriculoperitoneal shunting and adequately followed. Both operative mortality and deaths due to complications of this type of shunt were much lower than after ventriculocaval shunts. Although 44% required revision a third of the cases had a period of three years without revision; two-thirds of these went for three years after the initial operation without need for operation. This shunt should be considered both in children and in adults because it is no more likely to block than ventriculoatrial, is easier to revise, and the other complications are fewer and much less serious.

Adolescent↗
PubMed1973

Effect of carotid ligation on cerebral blood flow in baboons. I. Response to altered arterial PCO2.

Measurements of cerebral blood flow (CBF) were made in anaesthetized baboons before and after ipsilateral carotid artery ligation and also after bilateral carotid ligation. Results showed that at normocapnia (PaCO(2) 38-39 mmHg) there was little change in cerebral blood flow on ipsilateral carotid ligation, but when both carotid arteries were tied the blood flow to the brain fell significantly. At hypercapnia (PaCO(2) 58-60 mmHg) the CBF/CO(2) gradient fell significantly on ipsilateral carotid ligation; on bilateral carotid ligation there was only minimal rise in cerebral blood flow in response to the rise in PaCO(2). At hypocapnia (PaCO(2) 20-21 mmHg) the gradients of fall in the CBF were similar before and after ipsilateral carotid ligation; after bilateral carotid ligation there was minimal change in the CBF in response to the fall in the PaCO(2). It is suggested that, although cerebral blood flow may be normal after ipsilateral carotid ligation, the circulatory reserve of the brain is not sufficient to meet physiological challenges. This may be the reason for the development of delayed neurological complications after carotid artery ligation.

Animals↗