Biomedical subjects
Publications and source records attributed to B Jandolo.
12 patients with pituitary tumors were studied with VEP, to demonstrate involvement of the optic chiasma. In 3 patients VEP was recorded pre- and post-surgery to evaluate a modification in the shape and latencies of the potentials. 2 patients were studied only pre-surgery, the other 7 post-surgery. The utility of this test is discussed.
The silent period evoked by the electrical stimulus of the abductor pollicis brevis and the triceps surae muscles was studied in both normal subjects and in patients affected by spinal compression, by multiple sclerosis and by familial degenerative myelopathy. In normal subjects, the duration of the silent period is shorter in the upper limbs than in the lower limbs. In patients with spinal compression and multiple sclerosis, the duration of the silent period in the lower limb is significantly greater. On the contrary, the duration in familial degenerative myelopathy is significantly longer, recording from the abductor pollicis brevis. The authors conclude that this technique is useful in the diagnosis of spinal lesions from compression and demyelination.
Weakness of the flexor pollicis longus, flexor digitorum profundus and pronator quadratus is usually related to an isolated paralysis of the anterior interosseous nerve in the volar aspect of the forearm. The same syndrome may be caused by lesions of the median nerve in the supracondylar region and by involvement of the fibers assigned to the abovementioned nerve in the medial and lateral cords of the brachial plexus. We report 4 cases of the anterior interosseous nerve syndrome (3 spontaneous and one traumatic), review and discuss etiological factors, clinical features and electromyographic findings in the syndrome.
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We report a case of neuropathy of the lateral cutaneous nerve of the calf in a patient with inadequately controlled diabetes mellitus. The painful syndrome was controlled with carbamazepine.
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Three surgically verified cases of median nerve entrapment at and above the elbow are reported: one involved a compression of the nerve beneath the Struthers ligament in absence of supracondylar bony spur, and two concerned a compression beneath the lacertus fibrosus bicipitis (aponeurosis musculi bicipitalis brachii). Of the two latter cases, the first entrapment was caused by a hematome and the second the nerve was found to be entrapped between the lactertus and an underlying hypertrophic brachial muscle. The compression mechanisms and clinical and electromyographic findings are presented.
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Maximal conduction velocity in the supraorbital nerve (afferent fibers for the blink reflex) has been estimated in 12 normal subjects (on the right and left side): the mean value was 41 m/s. Furthermore, this investigation was made on 23 patients with different pathologies (9 with trigeminal neuralgia with hypoesthesia, 8 with multiple sclerosis, 6 with cerebellopontine angle tumor). Normal and pathological results are discussed and diagnostic prospects of this procedure evaluated.
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The present investigation evaluates those few patients of our series with basal ganglia and brain-stem tumor who refused either surgical decompression and biopsy or radiation therapy. Four patients were suffering from tumors of the basal ganglia and three from brain-stem tumors; all the tumors were diagnosed by classical neuroradiological investigations and computerized tomography. The patients were given CCNU by mouth, 13 mg/sq m every 6 weeks. No toxicity was recorded. Mean survival was 19 weeks for patients with basal ganglia tumors and 48 weeks for those with brain-stem tumors. All patients were evaluated with respect to the quality of survival. Results were compared with those obtained in a control group of patients who received methylprednisolone therapy only.
Early traumatic epilepsy, whose frequency is rather high, especially in children, is usually characterized by focal motor seizures (57%) or by generalized seizures (43%). The association of both running and laughing fits in the same patient on the contrary is quite exceptional, as only three cases have been reported in literature. There are no observations about temporal lobe epilepsy, nor, particularly, about running or laughing fits in early traumatic epilepsy. We report here the interesting case of a boy whose early traumatic epilepsy manifested itself as temporal lobe epilepsy characterized by running and laughter.
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The Authors describe a case of "stiff-man syndrome" accompanied by all clinical and laboratory examinations; they point out the unusual implication of facial muscles and briefly report pathogenic theories and diagnostical criteria of this syndrome.
The Authors report their experience in using water-soluble contrast medium in ventriculographies having carried out 102 ventriculographies partly with Dimer X and partly with "Uromiro 300". Their conclusions are practically similar to those already reported by the many Authors who have written on this subject: 1) facility of examination particularly in urgent cases; 2) excellent neuroradiological definition of the cases; 3) possibility of obtaining a selective ventriculography; 4) indication especially in space-occupying lesions of the posterior cranial contrast medium; 6) possibility of reducing complication rate by carefully carrying out the examination and by avoiding the use of excessive quantities of contrast. In particular the Authors describe some useful methods for obtaining better technical results from the examination and reducing the complication rate.
Lonidamine (LND) is a drug that interferes with energy metabolism of cancer cells, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). In such way LND could impair energy-requiring processes, as recovery from potentially lethal damage, induced by radiation treatment and by some cytotoxic drugs. A randomized study started in November 1983, to evaluate the efficacy of LND in association with radiotherapy as first line treatment in malignant gliomas, after surgical procedure. LND was also used in association with Lomustine (CCNU) at the moment of documented clinical and neuroradiological recurrence. At the present time 60 patients entered the study, and 47 are evaluable. Present preliminary results are not statistically significant, however indicate that LND tends to prolong the median survival time and the rate of one year survivors.