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Biomedical subjects

B József

Publications and source records attributed to B József.

10 recordsLinked to original sources
PubMed2001

Rare incidence of three consecutive primary tumors in the maxillofacial region: retinoblastoma, leiomyosarcoma, and choriocarcinoma: case report.

Multiple primary tumors occur more commonly in the region of the head and neck than elsewhere in the body. The chance of this is particularly high in patients treated for retinoblastoma, in part because of a genetic predisposition, and in part because of the possibility of irradiation treatment. However, triple tumors occur in only 0.5% of multiple tumors. A rare case of a triple (metachronous) tumor is reported: 12 years after the treatment of bilateral retinoblastoma (enucleation and irradiation), secondary leiomyosarcoma developed in the maxillofacial region, followed 5 years later by choriocarcinoma. Surgery was performed on all three types of tumor. As a result, the female patient (currently 21 years old) is now free of complaints and has married. It is extremely rare for either leiomyosarcoma or choriocarcinoma (CHC) to appear in the maxillofacial region. The long-term, systematic control of such patients is absolutely necessary, for the multiple tumors tend to develop only after a long latency period of 10 to 20 years.

Adolescent↗
PubMed1977

[Structure and configuration of human tendons. II. Development of tendon structure during ontogenesis].

In infants born in the 24th--30th weeks of the gravidity the praenatal development and the process of the organization of the tendinous structure have been examined by the authors. By means of photo- and polarization microscopic examinations it was found that the tendon of the flexor hand muscles (M. flexor carpi radialis, M. flexor digitorum comm.) shows mature tendinous structure earlier, than the tendons of the flexor muscles of the lower extremity (M. semitendinosus femoris, M. triceps surae). The tendons of the extensor muscles of the lower extremity (M. quadriceps femoris, M. tibialis ant.) are underdeveloped and inordinate in the foetal life--their structure develops only during the postnatal life.

Hand↗
PubMed1976

[Collagen synthesis, studied by sub microscopic methods in beta-propiolactone and in tendon homografts, preserved by gamma irradiation].

In dog experiments homologous tendos conserved in beta-propiolacton and by means of gamma-radiation have been transplanted by the authors. After the 1st, 3rd and 8th post-operative week various regions of the graft and the recipient tendon stump have been examined by means of light--, polarisation microscopic and electron microscopic method. The examinations have unanimously shown that the tendon grafts conserved in beta-propiolacton are reorganized quickly, within 8 weeks nearly completely besides hardly visible inflammatory reaction. In the meantime, the originally collagen fibrous framework is decomposed and on it a new collagen fibrous structure develops, and thus a new tendon--capable to function--is formed. On the other hand, the reorganization of the grafts conserved with gamma-radiation is protracted or it fails to occur, and cicatrization is observed. Some problems of the modern tissue preservation, the collagen synthesis occurring in the active fibroblasts, the secretion of the collagen precursory substance into the extracellulary space, as well as the formation, the structure and the constitution of the newly synthesized collagen fibres--forming the transplant--are discussed by the authors. The obtained results are demonstrated in light-, polarization microscopic and electron microscopic pictures.

Animals↗
PubMed1976

[Constitution and structure of human tendons].

In this introductory study our actual knowledge on the tendons is resumed and it is pointed out that on the basis of this knowledge no explanation is given as regards the pathomechanism of the "spontaneous" tendon ruptures. The authors' concept on the tendons as motor units is discussed. The examinations are dealt with, by which the authors intend to revise the conventional static tendon model.

Elasticity↗
PubMed1976

[Pig skin xenograft in burns. I. Technology, laboratory studies. II. Clinical experience].

The technology of the preparation of certainly sterile xenograft--pig's skin has been examined by the authors before the therapeutical use. On the basis of their examinations it was found by the authors that 2500 krad gamma radiation is suitable for the sterilization of the pig's skin--for the preparation of both the nature or lyophilized skin--since at this radiation value the pig's skin suffers no injury. After the preparation of the xenograft its clinical use has been initiated with certainly sterile material in children with burns. Xenograft has been used on 50 occasions, chiefly after surgical necrectomy, as provisional biological dressing. On the basis of their satisfactors results the authors advocate the use of the xenograft in burns, in certain skin affections, in clinical pictures concomitant with skinning and cutaneous necrosis and generally in all cases, in which skin grafting in necessary.

Animals↗