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Biomedical subjects

B J Wallace

Publications and source records attributed to B J Wallace.

45 records · Page 3Linked to original sources
PubMed1966

Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli.

Pittard, James (School of Microbiology, University of Melbourne, Victoria, Australia), and B. J. Wallace. Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli. J. Bacteriol. 91:1494-1508. 1966.-A number of mutant strains of Escherichia coli K-12, which are blocked in the biosynthesis of the aromatic amino acids, were examined biochemically to determine their particular enzymatic deficiencies. The mutations carried by these strains were mapped by use of the methods of conjugation and transduction. Structural genes for five of the enzymes of the common pathway leading to chorismate and for the two enzymes converting chorismate to phenylpyruvate and p-hydroxyphenylpyruvate, respectively, were identified. Unlike the genes of the tryptophan operon most of these genes are distributed over widely separated regions of the chromosome.

Amino Acids↗
PubMed1966

Gene controlling the uptake of shikimic acid by Escherichia coli.

Pittard, James (University of Melbourne, Melbourne, Australia), and B. J. Wallace. Gene controlling the uptake of shikimic acid by Escherichia coli. J. Bacteriol. 92:1070-1075. 1966.-Mutants possessing an impaired ability to take up exogenously supplied shikimic acid were isolated. Mutants showing either a complete or partial loss of this activity were found. The mutations have been mapped on the Escherichia coli chromosome and occur in a single gene, situated near to the cluster of genes concerned with histidine biosynthesis. The uptake of dehydroshikimic acid was also affected by these mutations, suggesting a common mechanism for the uptake of these two related intermediates of aromatic biosynthesis.

Carbon Isotopes↗