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Biomedical subjects

B J Murray

Publications and source records attributed to B J Murray.

At least 37 records · Page 2Linked to original sources
PubMed1987

Medical complications of herpes zoster in immunocompetent patients.

The vast majority of the more than 300,000 annual cases of herpes zoster in the United States occur among healthy, immunocompetent persons. Most patients recover from reactivated varicella-zoster infection, but some experience complications. The most common of these is postherpetic neuralgia, but other neurologic as well as ocular and dermatologic complications can occur as well. Zoster during pregnancy is not of serious concern. Ongoing trials of antiviral agents are aimed at resolving the infection quickly and decreasing the incidence and severity of postherpetic neuralgia.

Acyclovir↗
PubMed1986

The hepatitis B carrier state.

Acute hepatitis B virus infection resolves in 95 percent of patients within one year. The remaining 5 percent have persistent infection and become chronic carriers. In the United States, there are nearly one million carriers, who are at increased risk of developing immune-complex disorders and liver diseases. Treatment is available to reduce vertical transmission, and ongoing trials of immunosuppressive and antiviral agents are aimed at decreasing or resolving viral replication.

Antiviral Agents↗
PubMed1986

Campylobacter enteritis--a college campus average incidence and a prospective study of the risk factors for exposure.

In a prospective study over two years at a university student health center, the average incidence for Campylobacter enteritis was 4.5 cases per 1,000 students for a nine-month academic year. Male students were more likely to submit a stool specimen for examination and were more likely to have Campylobacter enteritis. Campylobacter enteritis was ten times more common than Salmonella and Shigella enteritis combined. The only identifiable increased risk for Campylobacter enteritis developing among patients with acute diarrheal illness was the recent ingestion of barbecued chicken.

Adult↗
PubMed1985

The polypeptide structure and assembly of Ly-2/3 heterodimers.

Mild reduction of mature, thymic Ly-2/3 heterodimers of Mr 67 000 resulted in dissociation into three individual polypeptide chains, alpha, alpha', and beta, of respective Mr values 38 000, 35 000, and 30 000. The alpha and alpha' chains were both immunoprecipitated by a monoclonal antibody directed to the Ly-2.1 epitope whereas the Ly-3.1 antibody bound only the beta chain. The possibility that the alpha and beta chains of each heterodimer established their interchain links within a labile precursor protein in which alpha and beta segments were fused was considered but discounted by the finding that in mice heterozygous for both Ly-2 and Ly-3 loci, the Ly-2 product of one chromosome was not exclusively joined to Ly-3 structures coded by the same chromosome. By utilizing ionic detergents which selectively alter the charge of intrinsic membrane proteins, both Ly-2 and Ly-3 polypeptides were shown to have membrane insertion sites. It is suggested that as a consequence of their likely synthesis on membrane-bound polysomes, newly synthesized Ly-2 and Ly-3 structures accumulate within the same subcellular compartment - the membranes of the rough endoplasmic reticulum. Their elevated concentration within this space may facilitate a low affinity binding interaction between Ly-2 and Ly-3 which is later stabilized by interchain disulfide bond formation.

Animals↗
PubMed1984

Comparison of thymic and peripheral T cell Ly-2/3 antigens.

Major structural differences occur between the thymic and peripheral T cell forms of the Ly-2/3 antigen. Thymus Ly-2/3 consists of similar amounts of two types of disulfide-linked heterodimer, alpha beta and alpha' beta (Mr alpha = 38000, Mr alpha' = 35000, Mr beta = 30000). In contrast material from peripheral T cells consists almost exclusively of alpha beta dimers. The alpha chains of thymus and peripheral T cells differ also in isoelectric point with the thymic alpha chain being the more acidic. Based on peptide mapping experiments the alpha and alpha' chains of thymus are likely to be alternatively modified forms of the same polypeptide backbone. Individual T cell clones or T cell tumors propagated in vitro exhibit either a typical thymus or a typical peripheral T cell Ly-2/3 polypeptide pattern indicating that the synthesis of both alpha and alpha' chains can occur in the same cell. The heterogeneity of thymic Ly-2/3 can be considerably reduced by removal of sialic acid residues, and after desialylation the alpha chains of thymus and a cloned cytotoxic T lymphocyte (CTL) line cannot be electrophoretically distinguished. If Ly-2 structures affected the antigen specificity of CTL, a different structural variant would be expected in individual clones. The electrophoretic identity of desialylated thymus and CTL alpha chains suggests that Ly-2 does not exhibit clonal variation in polypeptide structure and, therefore, cannot contribute to antigen specificity.

Animals↗
PubMed1984

Medical complications of infectious mononucleosis.

Infectious mononucleosis is usually a benign, self-limited disease, but complications may develop in up to 5 percent of patients. The complications can be life-threatening and may precede, follow or coincide with the usual symptoms of infectious mononucleosis. Occasionally, a complication is the only clinical manifestation of the disease. Complications may be due to an autoimmune response, a lymphocytic infiltrative reaction, generalized edema of the airway tissues or enlargement of the spleen.

Adolescent↗