Biomedical subjects

B J Martin

Publications and source records attributed to B J Martin.

At least 37 records · Page 2Linked to original sources

PubMed1998

The acute effect of topical beta-adrenoreceptor blocking agents on retinal and optic nerve head circulation.

PURPOSE: Topical beta-blockers are the most common treatment for ocular hypertension in glaucoma, but their ocular hemodynamic effects are not well known. We investigated the acute effects of betaxolol (beta-1 selective antagonist), levobunolol (non-selective antagonist with active polar metabolite), and timolol (non-selective antagonist) on retinal and superficial optic nerve head circulation. METHODS: Intraocular pressure (IOP), heart rate, blood pressure, and retinal circulation were evaluated in 12 healthy subjects (6F/6M; mean age=24+/-2 years) before and two hours after instillation of each drug on separate occasions at least two weeks apart. Macular capillary blood velocity (MCBV), epipapillary blood velocities (EBV), arteriovenous passage (AVP) times, and arterial and venous diameters were measured by digital image analysis of scanning laser fluorescein angiograms. RESULTS: All drugs significantly (p<0.05) reduced IOP. There was no significant effect on blood pressure or calculated ocular perfusion pressure. Only levobunolol significantly lowered heart rate (p<0.05). Each drug produced a significant (p<0.01) decrease in AVP time of approximately 25%. MCBV was significantly (p<0.01) increased by approximately 20% in all three conditions; each drug also produced significant (p<0.01) increases in EBV. Arterial and venous diameters remained unaffected. CONCLUSION: All three drugs, despite different beta-adrenergic properties, increased blood velocities in retinal and epipapillary capillaries. These changes, occurring as they do in concert with decreased retinal arteriovenous passage time at constant retinal arterial and venous diameter, may indicate improved retinal perfusion after drug treatment. Improved circulation, if it indeed occurs, in tandem with reduced IOP, might explain in part the beneficial effect of beta-adrenoreceptor blocking agents in glaucomatous patients.

Administration, Topical↗

PubMed1998

Venipuncture in the medical physiology laboratory.

Medical physiology laboratories, traditionally devoted to animal experimentation, face unprecedented difficulties linked to cost, staffing, instrumentation, and the use of animals. At the same time, laboratory experiences with living creatures play a unique role in medical education. In this article we describe the use of venipuncture and subsequent blood analysis, with medical students serving as both subjects and experimenters, in a sequence of first-year physiology laboratories. These experiments are safe, robust, inexpensive, and time efficient, and they teach the principles of cardiovascular, respiratory, renal, nutritional, and gastrointestinal physiology. In addition, they enhance medical education in several other important dimensions. First, they teach safe venous blood collection and handling, a training appropriate for students at this level. Second, by serving each week as subjects as well as experimenters, students experience aspects of both sides of the doctor-patient relationship. Third, the laboratories can be used to teach fundamentals of research design and analysis. Finally, because blood analysis is central to medicine, and because the student's own blood data are discussed, students are enthusiastic and cooperative, and the clinical relevance of the data is clear.

Clinical Laboratory Techniques↗

PubMed1998

Pyruvate augments calcium transients and cell shortening in rat ventricular myocytes.

Pyruvate has been shown to be a metabolic inotrope in the myocardium. In millimolar concentrations, it has been shown to increase both myocardial phosphorylation potential and the cytosolic [NAD+]-to-[NADH] ratio. To determine if changes in these parameters can alter intracellular Ca2+ concentration ([Ca2+]i) and hence contractile function, Ca2+ transients and cell shortening (CS) were measured in isolated rat ventricular myocytes superfused with a physiological N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid buffer (11 mmol/l glucose) with and without additional pyruvate, L-lactate, acetate, or isoproterenol. The addition of 5 mmol/l pyruvate resulted in a 33% increase in CS and a 39% increase in systolic [Ca2+]i. These pyruvate effects were 70% of those observed with 100 nmol/l isoproterenol. The mitochondrial monocarboxylate transport inhibitor alpha-cyano-4-hydroxycinnamate (250 mumol/l) strongly inhibited pyruvate inotropy, suggesting a substantial obligatory coupling between pyruvate inotropism and its oxidation by the mitochondria. A possible role of the cytosolic [NAD+]-to-[NADH] ratio was assessed by comparing the effects of 20 mmol/l L-lactate to those of equimolar pyruvate. In contrast to 20 mmol/l pyruvate, excess L-lactate failed to appreciably increase CS or systolic [Ca2+]i. The findings imply that, at levels substantially above 5 mmol/l, a portion of pyruvate inotropism might be due to extreme cytosolic [NAD+]-to-[NADH] ratios. This study is the first evidence that augmented [Ca2+]i transients are most likely the mechanism of cardiac pyruvate inotropism.

Animals↗

PubMed1997

Effects of ischemia, preconditioning, and adenosine deaminase inhibition on interstitial adenosine levels and infarct size.

In order to examine the relationship between local adenosine concentrations before, during, and after ischemia and the extent of ischemic myocardial damage, measurements of interstitial fluid (ISF) nucleosides were made using microdialysis probes implanted in the ischemic region of isoflurane anesthetized Micropigs undergoing 60' coronary artery occlusion (CAO) and 3 h of reperfusion (REP). Nucleoside concentrations in the dialysate collected from the microdialysis probes were used as an index of ISF levels. Dialysate nucleoside concentrations (ADO, inosine and hypoxanthine), myocardial infarct size, and myocardial blood flow (MBF) were determined in control animals (n = 6), animals preconditioned with a single 10' cycle of CAO and REP (PC, n = 6), and those treated with the adenosine deaminase inhibitor pentostatin (n = 6, 0.2 mg/Kg i.v. 30' prior to CAO). The brief PC occlusion resulted in a transient but significant increase in dialysate ADO (6.7 +/- 1.8 microM vs. 0.67 +/- 0.1 microM at baseline). Pentostatin administration had no significant effect on either dialysate nucleosides or MBF at baseline. During the 60' CAO, dialysate ADO increased in control animals. In PC animals, however, dialysate ADO during CAO was lower than control. Pretreatment with pentostatin resulted in a six-fold augmentation in dialysate ADO during the 60 min CAO when compared to the control values (110.62 +/- 30.2 microM vs. 16.31 +/- 2.1 microM at 60 min of ischemia). Pentostatin also resulted in a significant reduction in the accumulation of inosine and hypoxanthine, indicating inhibition of adenosine deaminase activity. There were no significant differences in MBF between groups at any time point. Following 3 h REP, infarct size was 35.4 +/- 5.5%, 8.1 +/- 1.5% and 8.3 +/- 1.8% of the region at risk in control, PC, and pentostatin groups, respectively. These data suggest that marked increase in ISF ADO during CAO, may be as effective in reducing INF as a modest increase in ISF ADO prior to prolonged CAO.

Adenosine↗

PubMed1997

Analysis of the tonic vibration reflex: influence of vibration variables on motor unit synchronization and fatigue.

The influence of vibration frequency (40, 80, 100, 120, 150, or 200 Hz) at selected displacement amplitudes (0.2, 0.3 mm) on tonic vibration reflex (TVR) characteristics was investigated. The degree of synchronization of motor unit activity with vibratory stimuli in ten humans was determined using the electromyographic (EMG) activity of the finger and wrist flexor muscles when vibration was applied to the distal tendons of the hand flexor muscles. The EMG spectral analysis indicates that harmonic and subharmonic motor unit synchronization mechanisms contribute to the modulation of the amplitude of the TVR as the vibration frequency increases. Harmonic synchronization decreases while subharmonic synchronization increases as vibration frequency increases. It is suggested that the synchronization process influences muscle fatigue, since it forces the driving of motor units, leading to a decrease in contraction efficiency. This phenomenon most probably results from an impairment of excitation-contraction coupling. High-frequency vibration (> 150 Hz) tends to induce less motor unit synchronization in a frequency range beyond the known mechanical resonance of biological tissues. The findings of this study may be applied to the design of hand-held power tools, since their vibration triggers the TVR in active muscles.

Adult↗

PubMed1997

A neural network model for simulation of torso muscle coordination.

An artificial neural network (ANN) was created to simulate lumbar muscle response to static moment loads. The network model was based on an abstract representation of a motor control system in which muscle activity is driven primarily to maintain moment equilibrium. The network model parameters were obtained by an iterative method (trained), using a modification of the standard backpropagation algorithm and moment equilibrium constraints. In contrast to previous ANN models of muscle activity, patterns of muscle activity are not target (training) values, but rather emerge as a result of moment equilibrium constraints. Assumptions regarding the moment generating capacity muscles and competitive interactions between muscles were employed and enabled the prediction of realistic patterns of muscle activity upon comparison with experimental electromyographic (EMG) data sets (r2: 0.4-0.9). The success of the simulation model suggests that a motor recruitment plan can be mimicked with relatively simple systems and that 'competition' between responsive units (muscles) may be intrinsic to the learning process. Prediction of alternative recruitment patterns and differing magnitudes of co-contractile activity were achieved by varying competition parameters within and between units.

Abdominal Muscles↗

PubMed1997

Erythrocyte magnesium in elderly patients: not a reliable guide to magnesium status.

To assess body magnesium status in various illness states in older people by measurement of serum magnesium (S Mg) and erythrocyte magnesium (E Mg) and to explore the limitations of E Mg measurement. S Mg and E Mg were measured in 150 consecutive out-patients, mean age 77 years, and in 100 consecutive in-patient admissions, mean age 80 years. Results were analysed for different diagnostic groups S Mg was normally distributed for both in-patients and out-patients, mean values 0.79 mmol/l and 0.77 mmol/l respectively. In-patient E Mg concentrations were often higher but the distribution was considerably skewed, median 2.28 mmol/l, mean 2.35 mmol/l. Out-patient E Mg concentration followed a near normal distribution, median 2.32 mmol/l, mean 2.30 mmol/l. There was a significant correlation between E Mg and S Mg for out-patients, R = 0.29 (p < 0.001). In-patients with infections and pressure sores had significantly raised E Mg concentrations but normal or low S Mg. High E Mg concentrations in illness are likely to be due to alterations in characteristics of the erythrocytes themselves rather than an indication of body magnesium excess. E Mg concentrations in illness should be interpreted with caution.

Aged↗

PubMed1997

The effect of keyboard keyswitch make force on applied force and finger flexor muscle activity.

The design of the force-displacement characteristics or 'feel' of keyboard keyswitches has been guided by preference and performance data; there has been very little information on how switch 'feel' alters muscle activity or applied force. This is a laboratory-based repeated measures design experiment to evaluate the effect of computer keyboard keyswitch design on applied finger force and muscle activity during a typing task. Ten experienced typists typed on three keyboards which differed in keyswitch make force (0.34, 0.47 and 1.02 N) while applied fingertip force and finger flexor electromyograms were recorded. The keyboard testing order was randomized and subjects typed on each keyboard for three trials, while data was collected for a minimum of 80 keystrokes per trial. No differences in applied fingertip force or finger flexor EMG were observed during typing on keyboards with switch make force of 0.34 or 0.47 N. However, applied fingertip force increased by approximately 40% (p < 0.05) and EMG activity increased by approximately 20% (p < 0.05) when the keyswitch make force was increased from 0.47 to 1.02 N. These results suggest that, in order to minimize the biomechanical loads to forearm tendons and muscles of keyboard users, keyswitches with a make force of 0.47 N or less should be considered over switches with a make force of 1.02 N.

Adult↗

PubMed1997

Altered retrobulbar vascular reactivity in early diabetic retinopathy.

AIM/BACKGROUND: In diabetic eye disease the factors leading to compromised circulation and the resulting loss of visual function are poorly understood. Although retinal circulation has been widely investigated, it accounts for only a fraction of total eye blood flow. Blood flow was investigated in the larger vessels feeding the eye in patients with early diabetic retinopathy. METHODS: Eleven patients with early diabetes with minimal or no retinopathy and 11 healthy controls were evaluated for retrobulbar blood flow velocity using colour Doppler imaging for the ophthalmic and central retinal arteries. Patients and subjects were tested while breathing room air and again under conditions of isocapnic hyperoxia. RESULTS: Hyperoxia induced a significant change in the central retinal artery end diastolic velocity (EDV) (p = 0.008) and resistance index (RI) (p = 0.032) in normal subjects, but not in diabetic patients. Consequently, during hyperoxia, the diabetic patients were significantly higher for EDV (p = 0.006) and significantly lower for RI (p = 0.002) compared with normal controls. Hyperoxia caused no significant change in either group in the ophthalmic artery; nevertheless, under isocapnic hyperoxia conditions the diabetic patients had lower peak systolic velocity (p = 0.05) and lower RI (p = 0.05) than normal subjects. CONCLUSIONS: Imposition of isocapnic hyperoxia produces significant differences in the ophthalmic and central retinal artery blood flow velocities in diabetic patients with early disease when compared with normal subjects. These results demonstrate that diabetic patients with minimal or no retinopathy suffer from irregular ocular vascular function in the major vessels feeding the eye.

Adult↗

PubMed1997

Infarct size reduction with the nucleoside transport inhibitor R-75231 in swine.

Adenosine (Ado) has been reported to be cardioprotective in several models of myocardial ischemia. The nucleoside transport inhibitor R-75231 (R-75) has been reported to enhance local Ado concentrations and postischemic recovery of function, but little is known regarding its effects on myocardial infarct size. The purpose of the present study was to determine the effects of R-75 on infarct size and to measure myocardial regional Ado concentrations. Studies were conducted in pentobarbital-anesthetized swine undergoing 60 min of coronary artery occlusion and 2 h of reperfusion. Control pigs (n = 8) were compared with those receiving R-75 (0.1 mg/kg i.v.) 15 min before either occlusion (Pre R-75, n = 8) or reperfusion (Rep R-75, n = 8). Interstitial fluid (ISF) Ado, coronary venous Ado, and infarct size (% of the region at risk) were measured. In the Pre R-75 group, ISF Ado concentrations were significantly increased before and during ischemia, reaching a peak value of 71.8 +/- 8.6 microM (vs. 16.8 +/- 0.8 microM in control). ISF inosine and hypoxanthine concentrations were significantly reduced during ischemia in Pre R-75 animals. Infarct size was smaller in Pre R-75 compared with control (21.6 +/- 1.9 vs. 38.4 +/- 2.6%, P < 0.05). The Rep R-75 group had significantly elevated coronary venous Ado concentrations but no increases in ISF Ado or reduction in infarct size (33.5 +/- 3.5%). These data indicate that R-75 increases myocardial Ado and reduces infarct size when administered before coronary occlusion. The R-75-induced reduction in infarct size appears to be related to the augmentation of ISF Ado before ischemia rather than to increased plasma Ado during reperfusion.

Adenosine↗

PubMed1996

Derivation of Pasteurella multocida-free rabbit litters by enrofloxacin treatment.

Pasteurella multocida is an important bacterial pathogen of rabbits that is easily transmitted from infected does to their kits prior to weaning. Enrofloxacin, a flouroquinolone antibiotic, is effective at limiting nasal carriage of P. multocida in rabbits. To determine if enrofloxacin treatment of pregnant does infected with P. multocida can be used to produce P. multocida-free litters, groups of 3 rabbits were inoculated intranasally on day 10 of gestation with 1.0 x 10(6) P. multocida CFUs. Beginning on day 14, one group received enrofloxacin IM (5 mg kg-1, BID), and a second group received enrofloxacin in the drinking water (200 mgl-1). IM treatment continued until kindling, while PO treatment continued 1 week after kindling. A third group was infected but received only IM saline, and a fourth group was infected but not treated. In addition, a fifth group was neither infected nor treated. Culture of nasal lavage samples and tissues from does and kits showed that both routes of enrofloxacin treatment failed to completely eliminate P. multocida from does, but all kits from enrofloxacin-treated does were free from P. multocida. These results suggest that treatment does with enrofloxacin during the periparturient period may interrupt transmission of P. multocida from infected does to their kits and that this treatment may be useful for deriving Pasteurella-free rabbits from infected does.

Animals↗

PubMed1996

Effects of key stiffness on force and the development of fatigue while typing.

An experiment was conducted to investigate the effect of key stiffness on the development of fatigue, keyboard reaction forces, and muscle electromyography (EMG) responses. Six subjects typed continuously for 2 hours on each of two keyboards (0.28 N or 0.83 N resistance keys, presented in random order). Keyboard reaction force and root mean square finger flexor and extensor EMG were recorded for 2 minutes at 250 Hz for every 10 minutes subjects typed. After typing for 2 hours subjects were given a 2-hour rest break and then typed on the remaining keyboard for an additional 2 hours Fifty-four percent more peak force, 34% more peak finger flexor EMG, and 2% more peak finger extensor EMG were exerted while using the 0.83 N keyboard. Peak and 90th percentile values showed similar trends and were well correlated for force and finger flexor and extensor EMG. Subjects typed much harder than necessary (4.1 to 7.0 times harder on the 0.28 N keyboard and 2.2 to 3.5 times harder on the 0.83 N keyboard) to activate the keys. Fatigue was observed on the 0.83 N keyboard during 2 hours of continuous typing, but the trends were mild. It appears that the ratio of typing force to flexor EMG may not be a sensitive enough indicator of fatigue for low-force high repetition work.

Adult↗

PubMed1996

Hyperoxia improves contrast sensitivity in early diabetic retinopathy.

AIM: The cause of vascular and visual pathology in diabetic retinopathy remains unknown. If retinal hypoxia plays a role, then early in the course of diabetes 100% oxygen breathing should normalise both contrast sensitivity and retinal blood flow. METHODS: This hypothesis was tested in 12 diabetic patients with minimal retinopathy who, none the less, exhibited reduced contrast sensitivity (p = 0.003 versus 12 age and sex-matched controls) and prolonged retinal arteriovenous dye transit (p = 0.0001 versus controls). RESULTS: Isocapnic hyperoxia failed to alter contrast sensitivity in controls, while it significantly improved contrast sensitivity in patients (at 12 cpd; p = 0.042) to levels indistinguishable from normal. Individual improvement in contrast sensitivity correlated positively with the severity of the initial defect (r = +0.84, p = 0.0008). Hyperoxia also had haemodynamic effects; it slowed retinal arteriovenous passage of fluorescein dye in controls, but did not further slow this transit time in patients. CONCLUSIONS: These results demonstrate the reversibility of early contrast sensitivity deficits in diabetes mellitus, and support the hypothesis that factors linked to tissue hypoxia initiate both visual and vascular dysfunction in diabetic retinopathy.

Adult↗

PubMed1996

Keyboard reaction force and finger flexor electromyograms during computer keyboard work.

This study examines the relationship between forearm EMGs and keyboard reaction forces in 10 people during keyboard tasks performed at a comfortable speed. A linear fit of EMG force data for each person and finger was calculated during static fingertip loading. An average r2 of .71 was observed for forces below 50% of the maximal voluntary contraction (MVC). These regressions were used to characterize EMG data in force units during the typing task. Averaged peak reaction forces measured during typing ranged from 3.33 N (thumb) to 1.84 N (little finger), with an overall average of 2.54 N, which represents about 10% MVC and 5.4 times the key switch make force (0.47 N). Individual peak or mean finger forces obtained from EMG were greater (1.2 to 3.2 times) than force measurements; hence the range of r2 for EMG force was .10 to .46. A closer correspondence between EMG and peak force was obtained using EMG averaged across all fingers. For 5 of the participants the force computed from EMG was within +/-20% of the reaction force. For the other 5 participants forces were overestimated. For 9 participants the difference between EMG estimated force and the reaction force was less than 13% MVC. It is suggested that the difference between EMG and finger force partly results from the amount of muscle load not captured by the measured applied force.

Adult↗

PubMed1996

Laser Doppler flowmetry measurement of changes in human optic nerve head blood flow in response to blood gas perturbations.

PURPOSE: The objective of this study was to establish the ability of laser Doppler flowmetry to detect relative changes in human optic nerve head hemodynamics caused by physiologic blood gas perturbations. METHODS: Laser Doppler flowmetry permits the noninvasive assessment of relative blood velocity, volume, and flow (flux) in a sample volume of the nerve head. Such measurements were performed in two groups of healthy subjects. The first group (n = 11) was tested during normal room air breathing and then while breathing 100% oxygen (isocapnic hyperoxia). The second group (n = 10) was also tested under normal conditions as well as during isoxic hypercapnia (+ 15% end-tidal carbon dioxide). Results were analyzed by paired t tests. RESULTS: Hyperoxia created a significant 25% (p = 0.002) decrease in optic nerve head blood flow, with blood volume decreased by 9% (p = 0.095) and blood velocity reduced by 13% (p = 0.154) compared to the room air condition. During hypercapnia, optic nerve head blood flow was increased by 28% (p = 0.012), with blood volume increased by 22% (p = 0.017) and blood velocity increased by 9% (p = 0.218) as compared to the normal room air condition. CONCLUSION: Blood flow in the optic nerve head capillaries changes in response to hyperoxia and hypercapnia as demonstrated in the brain and retina. Laser Doppler flowmetry permits the noninvasive assessment of these responses in humans under conditions within the physiologic range.

Adult↗

PubMed1996

Distributed moment histogram: a neurophysiology based method of agonist and antagonist trunk muscle activity prediction.

A neurocortical-based technique of muscle recruitment is presented to solve the muscle indeterminacy problem for lumbar torso modeling. Cortical recordings from behaving primates have established motor cortex cells that respond to a wide range of task directions, but are tuned to a preferred direction. A characteristic activity pattern of these neurons seems to be associated with effort direction. It was hypothesized that a model which recruits muscles based on a similar distribution would predict antagonistic muscle activity with greater realism than a widely referenced optimization formulation. The predictions of the Distributed Moment Histogram (DMH) method were evaluated under common speed (< 30 degrees s-1) sagittal plane lifting conditions using five subjects. The predicted forces showed high correspondence with agonist and antagonist myoelectric patterns. The mean coefficient of determination for the erector spinae was r2 = 0.91, and 0.41 for the latissimus. For the antagonistic muscles, the rectus abdominus was found to be electrically silent (< 3% MVC) and no activity was predicted by the method. The external oblique muscle was observed to be minimally active (< 16% MVC), and the DMH method predicted its mostly constant activity with a mean standard error of 1.6% MVC. The realistic antagonistic predictions supported the hypothesis and justify this cortical based technique as an alternative for muscle tension estimation in biomechanical torso modeling. A primary advantage of this method is its computational simplicity and direct physiologic analog.

Abdominal Muscles↗

PubMed1995

A back-propagation neural network model of lumbar muscle recruitment during moderate static exertions.

A model employing artificial neural networks (ANNs) is developed for the prediction of lumbar muscle activity in response to steady-state static external moment loads. The model is constructed using standard feedforward networks and trained with available data using the standard back-propagation algorithm. Training with a limited set of exemplars allowed accurate prediction of muscle activity for novel moment loads (generalization). Sensitivity analyses during training and testing phases showed that the choice of specific network parameters was not critical except at extreme values of those parameters. Model predictions were better correlated with experimental data than predictions made using two optimization-based methods (average r2 = 0.83 using ANNs and 0.65 using optimization). The results suggest that lumbar muscle response varies smoothly and consistently with respect to the magnitude and orientation of external moments, and they also imply an upper limit on the accuracy of muscle activity prediction using only moment loads as input. ANNs present a useful alternative to EMG- and optimization-based approaches by being both 'reality-based' and predictive.

Biomechanical Phenomena↗

PubMed1995

Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma.

PURPOSE: beta-Adrenergic blocking drugs lower intraocular pressure. The question of whether these drugs also alter, either directly or indirectly, orbital hemodynamics is potentially of great importance for patients with normal-tension glaucoma who may have some degree of reversible vasospasm. METHODS: We compared the effect of selective (betaxolol) and nonselective (timolol) beta-adrenergic blocking drugs on flow velocities (as determined by color Doppler imaging) in orbital vessels in 13 patients with normal-tension glaucoma (mean age, 62 +/- 3 years; mean intraocular pressure, 15 +/- 2 mm Hg). A one-month drug treatment double-masked crossover design, with a three-week washout before each drug, was used. RESULTS: Neither drug changed peak systolic velocity in any of the four vessels studied (ophthalmic, nasal and temporal posterior ciliary, and central retinal arteries). Additionally, timolol did not alter end-diastolic velocity or resistance index (defined as [peak systolic velocity minus end-diastolic velocity] divided by peak systolic velocity) in any of the vessels measured. In contrast, betaxolol tended to increase end-diastolic velocity and to decrease resistance index: the four-vessel average end-diastolic velocity increased 30% (P = .08), and the four-vessel average resistance index decreased significantly (P = .04). These reductions in resistance index occurred despite that betaxolol, in contrast to timolol, did not significantly decrease intraocular pressure. CONCLUSIONS: These results suggest that, in patients with normal-tension glaucoma, selective beta-adrenergic blockade (betaxolol) may have ocular vasorelaxant effects independent of any influence on intraocular pressure, whereas nonselective blockade (timolol) lowers intraocular pressure without apparently altering orbital hemodynamics.

Arteries↗