Interactant structure and complex stability for complexes of theophylline with cinnamate esters and related compounds in aqueous solution.
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Chemical Phenomena↗
Biomedical subjects
B J Kline
Publications and source records attributed to B J Kline.
Penetration of moxalactam and cefazolin into bone following simultaneous bolus or infusion.
The penetration of cefazolin and moxalactam into bone was studied in 20 adults scheduled for total hip arthroplasty. Patients randomly received both moxalactam and cefazolin (10 mg/kg of each) by either a rapid bolus or a 30-minute infusion. Serum and bone-extract concentrations were measured by HPLC. Serum concentrations of cefazolin were significantly greater than those of moxalactam at 15 minutes, 30 minutes, and at the time of bone removal for both rates of injection. Bone concentrations of cefazolin were significantly greater than those of moxalactam for both the bolus study (7.7 +/- 4.8 micrograms/g versus 5.4 +/- 3.4 micrograms/g) and the infusion study (5.6 +/- 3.4 micrograms/g versus 4.3 +/- 2.6 micrograms/g, respectively). There was no significant difference in the bone levels for the two drugs when penetration was expressed as a function of the simultaneous serum concentration (18% for each drug), and there were no significant differences in bone concentrations between the two rates of administration.
Adult↗
Effect of food on ethambutol absorption.
The effect of food on the absorption of ethambutol hydrochloride tablets was investigated. Following an overnight fast, 11 normal volunteers ingested ethambutol hydrochloride tablets (15 mg/kg dosage) once while fasting and once immediately following a standardized breakfast. The sequence of administration was assigned randomly. Food and fasting trials were at least seven days apart. In both trials, blood samples were drawn at 1, 2, 3, 4, 6, 8, 12, and 24 hours after dosing. Ethambutol concentrations in plasma were determined by a gas-chromatography method. Completeness of absorption was assessed by calculation of the area under the 24-hour plasma concentration curve (AUC) for each subject after each mode of administration using a trapezoidal approximation. Within-subject difference in AUC between food and fasting conditions was evaluated using the Student's t test for paired data. There was no significant difference between the mean AUC-fasting and the mean AUC-food (p greater than 0.05). Food does not appear to influence the extent of ethambutol absorption.
Ethambutol↗