Peri-articular calcification with fluid levels in secondary hyperparathyroidism.
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Adult↗
Biomedical subjects
B J Junor
Publications and source records attributed to B J Junor.
The treatment of renal osteodystrophy with 1-alpha-hydroxycholecalciferol.
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Alkaline Phosphatase↗
Hyperparathyroidism in chronic renal failure.
The high circulating concentrations of immunoassayable parathyroid hormone observed in chronic renal failure are due to a number of factors. These include altered metabolism of the hormone and also end-organ unresponsiveness which may, indirectly, cause increased secretion of parathyroid hormone. The response of the overactive parathyroid glands to changes in plasma calcium and magnesium is variable and caution is needed in evaluating the suppressibility of parathyroid hormone secretion in acute studies. 1alpha-Hydroxylated derivatives of vitamin D can effectively suppress parathyroid gland overactivity. This effect may not necessarily be medicated through hypercalcaemia and vitamin D metabolites may act directly on the parathyroid glands.
Calcium↗
The effect of 1alpha-hydroxyvitamin D3 on calcium and mineral content of bone in renal osteodystrophy.
Ten patients with renal osteodystrophy were treated with 1alpha-hydroxyvitamin D3 for 18 months. The effect of treatment was measured by a number of different methods and bone mass assessed by mineral and neutron activation analysis. In the majority of patients, raised serum levels of parathyroid hormone and alkaline phosphatase, histological features and radiological changes returned to normal. These effects were inconsistent in patients with a raised serum calcium level before starting treatment. In general, in patients without evidence of severe hyperparathyroidism there was a reduction in the rate of fall or an increase in the mineral and calcium content of the bone.
Alkaline Phosphatase↗
Xeroradiography of the hand in patients with renal osteodystrophy.
The hands of 40 patients with chronic renal failure and varying degrees of renal osteodystrophy were studied. The xerograph and radiograph of each patient were compared, assessing the degree of subperiosteal erosion, and of vascular, capsular and ectopic calcification. While the changes of osteodystrophy were clearly demonstrated on the xeroradiographs, they were also seen on the radiographs, even when only minor changes were present. The authors prefer the xeroradiograph for the measurement of the metacarpal cortical thickness, because of the sharp medial border of the cortex afforded by the "edge enhancement" of this technique.
Chronic Kidney Disease-Mineral and Bone Disorder↗
Renal biopsy in the milk-alkali syndrome.
In milk-alkali syndrome the degree of renal impairment varies greatly. Few reports have been published describing structural changes on renal biopsy. In three illustrative cases, impairment of renal function was related to morphological changes shown on percutaneous biopsy. Milk-alkali syndrome should be considered as a cause of renal dysfunction in patients with a long history of dyspensia.
Adult↗