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B J Fuller

Publications and source records attributed to B J Fuller.

132 records · Page 8Linked to original sources
PubMed1976

Solution shift performance in the elderly.

Seventy-two elderly adults were presented a concept problem which varied as a function of type of solution shift (reversal or nonreversal) and stimulus materials (compact designs, distributed designs, or distributed foods). Both trials to criterion and postshift error patterns were analyzed. Results indicated that stimulus materials affected postshift performance and that the elderly do respond in a dimensional fashion under some circumstances. Examination of individual protocols revealed that a rigidity notion would not account for the difficulty the elderly experienced when solution was shifted. Several alternative explanations were offered for the failure of many volunteers to solve the postshift problem.

Aged↗
PubMedDate not supplied

Cryopreservation of human oocytes: a review of current problems and perspectives.

It is well recognized that the ability to cryopreserve unfertilized human oocytes would make a significant contribution to infertility treatment. However, despite considerable interest, very few successful pregnancies have arisen from cryopreserved oocytes after thawing, insemination and transfer of the subsequent embryo. The reasons for this lack of progress may well result from a dearth of information on how the various biophysical changes during a cryopreservation regimen affect human oocyte function. Recently, fundamental studies on the effects of cooling, membrane permeability, cryoprotectant addition and ice formation have been performed on human oocytes by a number of groups, and these form the basis of the current review. It is likely that successful human oocyte cryopreservation will only follow once these factors are fully understood, but the existing base of knowledge should provide a platform for further improvements in the techniques currently employed.

Cell Membrane Permeability↗
PubMedDate not supplied

[Energy status of isolated hepatocytes after long-term cold storage in various types of media].

Using of isolated hepatocytes for investigation of the effects of hypothermia, it has been demonstrated that sucrose-base solution provides of maintenance of the energetic parameters (level of ATP, glucose synthesis, rate of gluconeogenesis) within 48 hrs of storage at 4 degrees C. It efficiency was compared with effect on the energetic status of isolated hepatocytes widely used preservation solution--solution of University Wisconsin (UW). After long-term of cold storage of isolated hepatocytes (72 hrs) at 4 degrees C in both solutions, it has been shown sharp decrease of ATP level (on two time). Viability of the liver cells (in both cases) was practically without change.

Adenosine Triphosphate↗
PubMedDate not supplied

Dynamics of the changes in homogenate respiratory activity after rat whole liver storage at 4 degrees C.

Homogenate respiratory activity was studied after different storage terms of the whole rat liver at 4 degrees C in sucrose-based solution and following normothermic reperfusion. Preservation of homogenate respiratory activity in all metabolic states after normothermic reperfusion of the control liver (60 min, 4 degrees C) is shown. Further storage (6 and 24 hrs) of isolated liver under the mentioned above conditions strengthens the substrate respiration of homogenate both after storage and after normothermic reperfusion. At the same time oxidative phosphorylation does not practically change. No change was noted in respiratory activity in the states 3, 4ADP and 3DNP after 24 hrs of liver storage in respect of a previous term. Following normothermic liver reperfusion contributes to a statistically true reduction of mentioned parameters of respiration, that correlates with a decrease in the degree of respiration and phosphorylation coupled of the studied system.

Animals↗