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Biomedical subjects

B J Feery

Publications and source records attributed to B J Feery.

At least 19 recordsLinked to original sources
PubMed1985

The incidence and type of reactions to plain and adsorbed DTP vaccines.

The incidence and type of reactions after administration of plain and adsorbed diphtheria-tetanus-pertussis vaccine were recorded in a blind controlled prospective study of 2041 vaccinations in 1075 infants receiving routine childhood immunization. There was no significant difference in the total incidence or type of general reactions after plain and adsorbed vaccine, but local reactions were significantly less frequent after plain vaccine. General reactions were recorded after 41.5% of vaccinations with plain vaccine and after 40.8% of vaccinations with adsorbed vaccine. Local reactions were reported in 66.7% and 76.5% of recipients respectively. The most commonly reported systemic reactions were irritability and fever. Three recipients of plain vaccine and one of adsorbed vaccine suffered hyporesponsiveness or collapse. One recipient of each vaccine suffered a convulsion. No persisting sequelae were recorded.

Adsorption↗
PubMed1982

Incidence and type of reactions to triple antigen (DTP) and DT (CDT) vaccines.

Local and general reactions were significantly more common in infants given DTP (triple antigen) vaccine than in those given DT (diphtheria and tetanus) vaccine. In 7712 DTP immunisations and 335 DT immunisations studied prospectively, local reaction rates were 47.8% and 33.7%, and general reaction rates were 38.4% and 10.1% respectively. The most commonly reported general reactions after both vaccines were irritability and fever. Persistent screaming was reported in 7.4% and 1.5% of vaccinees, and pallor or hyporesponsiveness in 1% and 0.3% respectively. Two infants developed convulsions and one suffered attacks of twitching after DTP immunisation. No persisting sequelae were detected.

Australia↗
PubMed1981

Diphtheria immunization in adolescents and adults with reduced doses of adsorbed diphtheria toxoid.

A study was undertaken in Schick-positive university students and schoolchildren to determine the diphtheria antitoxin response to vaccines containing a reduced dose of adsorbed diphtheria toxoid. It was found that the majority of participants, apparently previously sensitized, responded with an increase in antitoxin titre to protective levels after performance of the Schick test, or after the first dose of vaccine. A group of non-immune students required three doses of vaccine to reach adequate antitoxin levels to ensure durable immunity. Only one local reaction was observed in the group of 51 students, and this was attributed to an Arthus-type reaction involving the tetanus toxoid component of a combined adsorbed diphtheria and tetanus vaccine.

Adolescent↗
PubMed1981

Tetanus.

Tetanus results from the action of a powerful exotoxin produced by Clostridium tetani. It can be prevented only by active and passive immunization procedures. The vaccine is one of the safest and most effective vaccines ever developed, and is capable of inducing long term protection in individual vaccinees. Adequate immunization before, or during pregnancy can eliminate the risk of neonatal tetanus in infants born in developing countries. In non-immune patients, tetanus prophylaxis requires the use of tetanus immunoglobulin, or tetanus antiserum in addition to adequate wound care.

Humans↗
PubMed1979

Antibody responses to influenza vaccines containing A/USSR/90/77.

Studies were undertaken in adult groups aged 17-24 years, 25-64 years and 66-100 years to determine the haemagglutination-inhibiting antibody responses to sub-unit influenza containing A/USSR/90/77 (H1N1). Antibody responses to A/USSR/90/77 were low in all groups. The young adult group (17-24 years) produced a primary response to A/USSR/90/77 and showed a significant response to a second dose of vaccine, whereas their responses to the A/Texas/1/77 (H3N2) and B/Hong Kong/8/73 components were of the anamnestic type and showed no significant increase to a second dose. The adult (25-64 years) and aged (66-100 years) groups responded anamnestically to all three vaccine components. There was no impairment of the antibody response in the aged group in comparison with the response in the adult group. A comparative assay in microtitre trays and WHO plates showed two- to four-fold differences in antibody titre to A/USSR/90/77 in these systems.

Adolescent↗
PubMed1979

Different protection rates in various groups of volunteers given subunit influenza virus vaccine in 1976.

Different rates of protection were observed in various groups of volunteers given trivalent subunit influenza virus vaccine during an epidemic caused by A/Victoria/3/75 strains of influenza virus in Melbourne, Victoria, Australia, in 1976. The degree of protection varied from 80% protection from infection in one group to a moderation in the severity of clinical illness in a geriatric group. The response to immunization may depend on the previous experience of the vaccinees, and it may be necessary to use different dose schedules in different groups for optimal protection.

Aged↗
PubMed1978

Homologous and heterologous antibody responses to subunit influenza virus vaccine.

In a group of 32 adult volunteers given subunit influenza virus vaccine containing 250 international units (i.u.) of A/Victoria/3/75, 250 i.u. of A/Scotland/840/74 and 300 i.u. of B/Hong Kong/8/73, there were substantial increases in the geometric mean homologous haemagglutination-inhibiting (HI) antibody titres. There was also substantial boosting of the antibodies to the earlier variants of the Hong Kong (H3N2) series and to a later variant of the Asian (H2N2) series. There was no boosting of antibodies to the A/FM/1/47 strain, a representative member of the H1N1 series, but two individuals showed substantial rises to A/PR/8/34 (HON1). There were increases in the HI titre of antibodies cross reactive with two recent isolations, A/Texas/1/77, and A/Victoria/35/77, but the majority of vaccinees failed to reach antibody titres likely to be protective against such strains.

Antibodies, Heterophile↗
PubMed1978

Antibody responses to influenza vaccines containing A/New Jersey/8/76.

Studies were undertaken with whole virus, subunit and adsorbed subunit influenza vaccines containing the A/New Jersey/8/76 strain to compare the antibody response induced by immunization with these vaccines. There were no significant differences in the haemagglutination-inhibiton (HI) antibody responses to A/New Jersey/8/76 induced by these vaccines in the adult groups under study. Vaccinees over 23 years of age produced good HI antibody responses to one dose of vaccine. Neuraminidase antibody and complement-fixing (CF) antibody responses were determined for the A/Victoria/3/75 component of bivalent vaccines. There were significant increases in neuraminidase inhibiting (NI) antibody titres but no increase in the complement-fixing antibody titres after vaccination.

Adolescent↗
PubMed1977

Effect of dose on antibody response to subunit influenza vaccine.

In a group of third-year medical students who were given subunit influenza virus vaccine, the haemagglutination-inhibition (HI) antibody response to A/Victoria/3/75, and the boosting of HI antibody to previously circulating A strains of the Hong Kong subtype were independent of the dosage in the tested range. There was minimal boosting of antibody levels to the Asian strains which circulated during the childhood of the volunteers. The antibody responses to the B/Hong Kong/8/73 component were lower and were dose-related. There was no appreciable increase in the HI geometric mean titre to any of the strains after a second dose.

Antibodies, Viral↗
PubMed1977

Adverse reactions after smallpox vaccination.

Nine hundred and thirty-eight reports of adverse reactions of smallpox vaccination in Australia between 1960 and 1976 have been analysed according to the type of reaction, and the age and sex of vaccinee. In an estimated 5,000,000 vaccinations, the reaction rate was 188/million, and the death rate 1-5/million. Generalized vaccinia was the most common reaction. The more serious reactions--eczema vaccinatum, progressive vaccinia, and neurological and cardiac complications--accounted for 7-4% of the reports. A small number of rarely reported non-specific inflammatory reactions is also included. There was a marked difference in the number of reactions reported in females and males (the female-male ratio was 1-6:1), and this difference increased with age. Paradoxically, of eight reports of cardiac complications, seven concerned males. The administration of vaccinial immune globulin was usually followed by a rapid resolution of the adverse reactions.

Adolescent↗