Search PubMed⌕ Search

Biomedical subjects

B I Hirschowitz

Publications and source records attributed to B I Hirschowitz.

At least 181 records · Page 10Linked to original sources
PubMed1975

Marginal ulcer in achlorhydric patients.

Recurrent gastrojejunal ulceration is reported in three patients with histamine-fast achlorhydria. In none of these patients was extruding suture material responsible for the ulceration. However, all three patients had a history of alcohol abuse, and one abused aspirin as well. These cases demonstrate that achlorhydria does not protect against anastomotic ulceration. It is suggested that surgical manipulation produces an increased susceptibility to mucosal damage, and that it is erroneous to consider all anastomotic ulceration as a continuation or recurrence of acid peptic disease.

Achlorhydria↗
PubMed1975

Effects of vagotomy on urecholine-modified histamine dose responses in dogs.

Histamine step-dose responses, 2-100 mug/kg-h in 6 successive 45-min steps, were studied in nine dogs with gastric cannula. In three of the dogs the gastric fundus was selectively vagally denervated and the dose responses were repeated. In both groups of dogs the dose responses were then studied against background intravenous infusions of urecholine (10, 20, 40, and 80 mug/kg-h). Vagotomy acted as a competitive inhibitor (Km doubled from 14 to 29 mug/kg-h, while Vmax was unchanged) and this effect could be reversed by smaller than 10 mug urecholine/kg-h. In both groups increasing backgrounds of urecholine increased Vmax from similar to 14 meq H+/30 min to similar to 23-24 meq/30 min and decreased histamine km from 14 mug/kg-h to about 1-2 mug/kg-h. Both changes were log linear. The effects of urecholine on histamine-stimulated H+ secretion thus showed synergism (decreased Km) and potentiation (increased Vmax), the former interpreted as a cholinergic effect on the parietal cell histamine receptors and the latter as the probable existence of spare cholinergic receptors not (normally) accessible to histamine. There were no intrinsic qualitative or quantitative differences in these responses between the vagotomized and the innervated stomachs.

Animals↗
PubMed1975

Antigenic properties of subcellular fractions from canine pancreas: development of a zymogen membrane specific antibody.

Immunization of rabbits with a membrane preparation from dog pancreas produced precipitating antibody against an antigen present in the pancreas of several mammals. This antigen appears to be organ-specific but not species-specific and is localized in the pancreatic zymogen granule membrane fraction. It is thought to represent glycoproteins of mol wt 70,000-90,000 as well as a smaller species of mol wt less than 10,000.

Animals↗