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Biomedical subjects

B I Gel'tser

Publications and source records attributed to B I Gel'tser.

At least 19 recordsLinked to original sources
PubMed2006

[Relations between VDR3 and COL1A1 genes and markers of bone tissue metabolism in patients with chronic obstructive pulmonary disease].

AIM: To study correlation between polymorphism of the genes of vitamin D3 (VDR3), collagen of type 1 alpha-1 (COL1A1) and markers of bone tissue metabolism in chronic obstructive pulmonary disease MATERIAL AND METHODS: A total of 56 COPD patients were examined. Bone metabolism was evaluated by osteocalcin (OC) level and betaCL in the blood; BsmI polymorphism of gene VDR3 (genotypes BB, Bb, bb) and Sp1 polymorphism of gene COL1A1 (genotypes SS, Ss, ss)--by polymerase chain reaction. The control group consisted of 50 healthy persons of matched gender and age. RESULTS: OC and S allele were not the same in genotypes BB, Bb and bb. Ss and ss genotypes carriers had higher beta CL level than SS-carriers. SS and ss genotypes carriers did not differ with betaCL concentrations (p > 0.05). CONCLUSION: Testing of VDR3 and COL1A1 genes gives grounds for detection of predisposition to development of pulmonogenic osteopenic syndrome.

Biomarkers↗
PubMed2006

[Pharmacotherapeutic assessment of antiosteoporotic properties of alpha-calcidol in chronic obstructive pulmonary disease].

AIM: To evaluate antiresorptive properties of alphacalcidol in the treatment of osteopenic syndrome in patients with chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: A total of 94 COPD patients with low densitometric indices were studied for bone densitometric parameters, calcium-phosphorus metabolism, markers of bone tissue metabolism (osteocalcine-OC, tartrate-resistent acid phosphatase--TRAP, beta CrossLaps - BCL), cytokine profile in the course of 6-month continuous therapy with alpha-calcidol (alpha-D3-TEVA) in a dose 0.75-1 mcg/day. RESULTS: Six-month treatment with alpha-calcidol relieved pain, increased bone densitometric parameters, normalized calcium-phosphorus metabolism. While 3-month therapy induced positive dynamics in markers of bone metabolism (OC level increased, concentrations of BCL, TRAP reduced), 6-month therapy resulted in these parameters normalization close to the level of healthy persons. Proinflammatory cytokines (IL-1beta, IL-6 TNF-alpha) in COPD lowered significantly. CONCLUSION: Alpha-calcidol have analgetic, antiresorptive and immunomodulating effects which make this drug effective in prevention and pathogenetic therapy of osteopenic syndrome in COPD.

Adult↗
PubMed2005

Noninvasive study of vasodilatory activity of albino rat cerebral arteries.

Vasodilating activity of rat cerebral vessels was studied. Methodological peculiarities and chronotropic limits of vasomotor testing were determined. Qualitative and quantitative parameters of dilatation of vessels were determined and similarity of rat dilatation responses and human vasodilatory activity was described.

Animals↗
PubMed2005

[Functional condition of the vascular endothelium in patients with extrahospital pneumonia].

The purpose of the study was to investigate the vasomotor and NO-production functions of the endothelium (VFE and NOPFE) in patients with extrahospital pneumonia (EHP) of various severity. 60 patients with EHP of various severity, aged 18 to 35 years, were examined. VFE was studied by ultrasonic method (SonoLine Versa Plus, Siemens, Germany) using reactive hypermia test. NOPFE was investigated by measuring total level of NO metabolites by calorimetric method using Griess reagent. The total oxidative and total anti-oxidative activity (TOA, TAOA) in serum was determined. The study revealed functional disturbances of the vascular endothelium at the culmination of EHP. In cases of severe EHP there was insufficient vasodilatation and even vasoconstriction within the 1st minute after reactive hyperthermia test. During the recovery period the parameters were the same as in the patients of the control group. In cases of mild and moderate EHP moderate vasomotor dysfunction was observed, which was not seen during the recovery period. At the culmination of severe EHP NOPFE dysfunction was observed, which manifested by substantial decrease of basal NO secretion and low NO-reactivity of the endothelium (NORE). In cases of mild and moderate EHP low NORE and normal basal level of NO metabolites were seen. During the recovery period NORE returned to its normal level. The patients displayed TOA/TAOA disbalance in serum. There is a significant correlation between TOA/TAOA balance and the functional condition of the endothelium in patients with EHP. Thus, the study revealed endothelial dysfunction, which was strongly associated with the severity of the disease. TOA/ TAOA disbalance is a potential mechanism of endothelial dysfunction in patients with EHP.

Adolescent↗
PubMed2004

[Cytokine status in patients with chronic obstructive pulmonary diseases and its relationship with bone tissue functional state].

AIM: To study cytokine status in patients with chronic obstructive pulmonary disease (COPD) and its interrelations with bone metabolism. MATERIAL AND METHODS: The levels of pro-inflammatory and anti-inflammatory cytokines, bone metabolism markers in the blood were evaluated in 80 patients with COPD. RESULTS: Changes in cytokine status in COPD patients was established: an increase in pro-inflammatory cytokines and change in anti-inflammatory cytokines. There was hyperproduction of serum proinflammatroy cytokines (IL-1 beta, IL-6, IL-8, TNF-alpha) dependent on FEV1. IL-10 was markedly elevated (p < 0.05) while IL-4 had a trend to elevation (p > 0.05) in patients with COPD. A correlation analysis showed a positive correlation between IL-10, IL-4 and FEV1; IL-10, IL-4 and osteocalcine (bone formation marker), pro-inflammatory cytokines (IL-1 beta, IL-6 and TNF alpha) and Crosslaps (bone resorption marker). A negative correlation was discovered between IL-1 beta, TNF alpha and body mass index; IL-8 and osteocalcine. CONCLUSION: A significant role of cytokine-mediated mechanism in pathogenesis of pulmonogenic osteopenia.

Bone and Bones↗
PubMed2004

[Complex assessment of vasomotor function of vascular endothelium in patients with hypertension].

Vasomotor function of vascular endothelium was studied in 62 patients with grade 1-2 hypertension with moderate and high added risk. Methods included study of brachial and middle cerebral artery endothelium dependent and independent vasodilation/vasoconstriction, measurement of plasma levels of nitric oxide metabolites (NO(n)-), endothelin-1, and antithrombin, as well as registration of their changes during vasomotor tests with calculation of integral indexes. Most patients with hypertension differed from controls by preponderance of vasoconstrictor over vasodilator reactions both in peripheral and cerebral vascular bed. At the same time patients with hypertension had pronounced dissociation between vasomotor responses of cerebral and peripheral vessels compared with subjects with normal blood pressure (p<0.05). Besides lowered basal level of NO(n)- and high concentration of endothelin-1 patients with hypertension were characterized by hyperreactivity of nitricoxidergic system, augmented lability of endothelin producing system, and impaired athrombogenecity of vascular endothelium. Complex assessment of vasomotor function of vascular endothelium by sequential vasoactive tests characterizes functional and metabolic activity of cerebral and peripheral vessels and can be used for improvement of risk stratification and monitoring of efficacy of treatment of patients with hypertension.

Endothelin-1↗
PubMed2003

[Clinico-functional assessment of the daily dynamics of blood pressure in pneumonia patients].

AIM: To define the specific features of daily blood pressure (BP) variations in patients with extrahospital pneumonia (EHP) that has developed in the presence of baseline normotension and arterial hypertension (AH). MATERIAL AND METHODS: 83 patients aged 18 to 80 years who had EHP of varying severity were examined. Mild and moderate systolic and diastolic AH preceding EHP had occurred in 28 elderly patients. At the peak of the disease and before discharge, the patients underwent 24-hour BP monitoring with a portable ABPM-03 monitor ("Meditech", Hungary). RESULTS: At the peak of mild and moderate EHP, young patients had predominantly a normotensive daily BP curve whereas old patients with baseline normotension had systolic overload of target organs and a greater BP variability. At the peak of severe EHP, the normotensive patients had, irrespective of their age, systolic and diastolic arterial hypotension with a marked hypotensive overload and a low BP variability. In elderly patients with mild and moderate AH, non-severe EHP provoked negative changes in the daily BP profile (DBPP), which are indicative of an exacerbation of the disease as isolated systolic or systolic-and-diastolic AH, a greater BP variability, high values and rates of its morning elevation. At the peak of severe EHP, hypertensive old patients showed DBPP variations as two types: moderate systolic-and-diastolic hypotension or the unchanged hypertensive profile of a daily BP curve. CONCLUSION: Analyzing DBPP in patients with EHP has indicated that the nature and degree of its impairments at the peak of the disease are determined by three independent factors: age, severity of the disease, and baseline BP values. The findings may provide rational therapy for AH in patients with EHP.

Adult↗
PubMed2003

[Dynamics of a 24-h profile of arterial pressure and function of the vascular endothelium in nebivolol treatment of hypertensive patients].

To assess a hypotensive activity of nebivolol (nebilet) including its action on the 24-h profile and baroreceptor control of arterial pressure (AP), vegetative regulation of the heart and vasculomotor endothelial function in AP patients, 30 AH patients were given nebivolol in a dose 5 mg/day for 8 weeks. The results of the treatment show that nebivolol effectively maintains a safe 24-h control of AP, acts positively on chronostructure of AP 24-h profile, produced no clinically significant side effects, corrects vegetative heart regulation and improves baroreceptor AP control. Moreover, nebilet modulates a stable vasodilating effect which improves function of vascular endothelium, initiates regression of left ventricular myocardium hypertrophy by raising its elasticity without changing much its contractile function. Thus, nebivolol is a highly effective drug for treatment of arterial hypertension which corrects a wide spectrum of unfavourable shifts in cardiovascular system function.

Aged↗
PubMed2003

[Arterial hypertension in menopausal women: Clinical, functional, and pharmaco-economical aspects].

The study was undertaken to define the specific features of daily variations of blood pressure (BP) and autonomic cardiac regulation (ACR), as well as the functional status of the myocardium and vascular endothelium in females with menopausal arterial hypertension (MPAH) and to assess the pharmacotherapeutic and economical aspects of the combined use of arifon retard and clinonorm. The study enrolled 30 reproductive females with mild and moderate arterial hypertension (AH) and 65 females with MPAH who were randomly divided into 2 groups according to the therapeutic model. MPAH was characterized by more unfavorable hemodynamic changes that AH in the presence of preserved fertile function: greater load on target organs, elevated BP, its inadequate nocturnal lowering, greater BP variations, the magnitude and rate of its morning elevation. In AH, the vasomotor function of the endothelium varies with the clinical form of the disease and with the functional status of the female reproductive system. By and large, in the group of patients with MPAH, the latter was characterized by a more significant decrease in endothelium-dependent vasodilation (EDVD). Arifon retard monotherapy has an adequate antihypertensive effect in female patients with MPAH, by ensuring 24-hour control of BP and affecting its chronostructure. A combination of arifon retard and climonorm has no cumulative effect on the level of BP and on the parameters of pressure-induced load; however, this is a pathogenetically grounded combination that potentiates the positive effects of a diuretic in significantly improving EDVD and ACR. The use of arifon retard in combination with climonorm in MPAH is the most cost-effective for public health care facilities and effective for patients. The course of MPAH is of certain peculiarity, which should be taken into account in choosing a therapeutic model for this category of patients.

Circadian Rhythm↗
PubMed2003

[The test for nitric oxide metabolites in exhaled air condensate as a method of assessing NO-reactivity of the airways in patients with bronchial asthma].

AIM: To estimate airways NO-reactivity in response to their stimulation with fenoterol in different clinical forms of bronchial asthma (BA). MATERIAL AND METHODS: The study included 73 patients with BA: mild disease was in 21, moderate--in 24 and severe--in 28 patients. Severe BA patients were divided into two subgroups: with a stable course (n = 15) and unstable course (n = 13). NO-producing function of the airways was estimated by concentration of stable NO-metabolites (mNO)(NO2, NO3) in exhaled air condensate. RESULTS: Spontaneous NO-producing activity of the airways increases and reaches maximum in severe unstable asthma. Fenoterol-stimulated NO-production was minimal in mild BA while the most significant augmentation of mNO was observed in unstable BA. Basal level of mNO and velocity parameters of external respiration function correlated. CONCLUSION: Estimation of NO-reactivity of the airways in the test with fenoterol with calculation of the index of airways NO-reactivity provides additional information about respiratory system condition in BA patients which may be used in clinical pulmonology.

Asthma↗
PubMed2003

[Clinical efficiency of prognostic rules in patients with nonhospital pneumonia].

We studied efficacy of predicting outcomes of the disease in 345 patients (mean age 48.3 +/- 4.5 years) with extra hospital pneumonia (EHP). The risk of an unfavourable outcome was determined according to three prognostic rules (PR) of the British Thoracic Society. Ambiguity of the results necessitates specification of the PR indicators' prognostic value in respect to age and social aspects while PR assessment of the disease severity can serve an important tool in perfection of care for EHP patients.

Adolescent↗
PubMed2002

[Parameters of bone tissue density in patients with bronchial asthma].

AIM: To study bone density in patients with bronchial asthma (BA). MATERIALS AND METHODS: Bone densitometric indices were evaluated in 123 patients with BA in relation to the basic therapy, dosage, and the duration and severity of the disease. RESULTS: The bulk (59.3%) of BA patients is found to have the osteopenic syndrome whose detection rate increases with longer duration and greater severity. Decreased bone density is more evident with oral glucocorticoids (GCs) than with inhaled ones. The effect of topical GCs on bone density is determined by their bioavailability. The decrease in bone density is more noticeable in patients taking beclomethasone and minimal in those on basic fluticasone therapy. CONCLUSION: Considerable decreases in bone density in BA patients may be prevented by a rational basic therapy with first-line inhaled GCs with low bioavailability.

Adult↗
PubMed2002

[Alphacalcidol in the treatment of osteopenic syndrome in patients with bronchial asthma].

AIM: To assess effectiveness of alphacalcidol in the treatment of osteopenic syndrome in patients with bronchial asthma (BA). MATERIAL AND METHODS: 65 BA patients with low densitometric parameters of bone tissue density were examined for bone density, basic parameters of Ca-P metabolism and some markers of bone metabolism during 6-month therapy with alphacalcidol (alpha-D3-TEVA) in a dose 0.5-0.75 mcg/day. RESULTS: All the patients after 6 months of therapy experienced pain relief, normalization of calcium-phosphorus metabolism, lower risk of broken bones. Their bone tissue increased its density. CONCLUSION: Alphacalcidol has analgetic and antiresorptive properties. It effectively prevents and treats osteopenic syndrome in patients with bronchial asthma.

Adult↗
PubMed2002

[Baroreceptor regulation of arterial pressure in elderly patients with systolic and essential hypertension].

AIM: To study efficiency of baroreceptor regulation of circulation with reference to vegetative regulation of the heart (VRH) and 24-h rhythms of blood pressure (BP) in elderly patients with systolic hypertension (SH) and essential hypertension (EH). MATERIAL AND METHODS: Synchronous 24-h monitoring of BP, ECG with evaluation of VRH by the system Cardio Tens 01 (Meditech, Hungary), examination of BP baroreceptor regulation from carotid areas with the method "cervical Camera" and in performing active orthostatic test were conducted in 50 elderly patients with mild and moderate SH and EH. RESULTS: Weakening of BP baroresponse was more noticeable in SH patients than in EH patients though the cardiochronotropic component of baroreflex in EH was stronger. Stimulation of the carotid baroreflex by elevated BP is accompanied by different weakening of adrenergic efferentation depending on AH form. The results of testing baroreflex by BP reduction in the group of SH patients point to the absence of efficient reactions of systemic circulation. In EH, circulation reacts extra actively. The condition of the cardiovascular system in SH is characterized by marked amplitude hypertension and asynchronous 24-h rhythm of vegetative impacts on the myocardium in the presence of subnormal afferentation of carotid receptors. CONCLUSION: The baroreflex control of the cardiovascular system in various forms of AH differs from that of normotensive subjects. The baroreflex and parameters of 24-h profile of AP and VRH are correlated.

Aged↗