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Biomedical subjects

B Hunter

Publications and source records attributed to B Hunter.

101 records · Page 6Linked to original sources
PubMedDate not supplied

Creatine kinase release from isolated EDL muscles in chronic ethanol-treated rats.

Chronic ethanol abuse has been shown to cause damage to skeletal muscle in animals and patients as reflected by elevated serum levels of cytosolic enzymes and histological examination. The present study investigated the hypothesis that elevated serum creatine kinase levels in ethanol-treated animals vs. sucrose control animals may result from increased enzyme release or efflux from muscle. Creatine kinase release was measured from extensor digitorum longus (EDL) muscles isolated from rats chronically treated for 28 weeks with ethanol and from sucrose fed controls. The in vitro cumulative release of creatine kinase over a 2-h period was significantly higher in the ethanol-treated animals. Consistent with an increased release of enzyme into the bath, creatine kinase levels in muscle homogenates at the end of the incubation period were lower in the ethanol-treated animals. Creatine kinase levels in serum obtained from trunk blood samples were statistically higher in the ethanol-treated animals compared to sucrose controls. These findings demonstrate increased enzyme release from fast-twitch skeletal muscle in chronic ethanol-treated rats.

Animals↗
PubMedDate not supplied

[Solitary rectal ulcer syndrome].

The solitary rectal ulcer syndrome is an infrequent entity consisting of a rectal lesion, caused by straining during defecation; it is characterized by specific histological changes. The condition is most frequent in adults between 30 and 50 years of age, but a few pediatric cases have been reported. Five patients (4 boys) are presented. All suffered from moderate rectal bleeding, straining, tenesmus and mucous discharge. One of them had clinical and endoscopic evidence of rectal prolapse. On defecography all children showed failure of pelvic floor relaxation during straining. Endoscopic evaluation showed single or multiple ulcers in four patients and a nodular fibrotic lesion in one. The histopathology of the rectal mucosa revealed replacement of the stroma of the lamina propria by collagen, lack of orientation of smooth muscle fibers and considerable hyperthopy of the muscularis mucosae. Medical treatment was satisfactory in four patients, one case required transabdominal rectopexy for relief of his symptoms. The most appropriate form of treatment has not been determined, but surgery should be used when prolapse is a prominent clinical feature. Greater awareness of this condition will lead to more frequent diagnosis.

Adolescent↗
PubMedDate not supplied

Demyelinating peripheral neuropathy in a guinea hen associated with subacute lead intoxication.

In mammalian species lead acts primarily as a neurotoxin. Lead poisoning is common in avian species but lesions in the nervous system have not been associated with it. This paper describes a peripheral neuropathy with fragmentation and segmental demyelination of fibers in the sciatic nerves of an adult guinea hen (Numida meleagris) which died of lead poisoning.

Animals↗
PubMedDate not supplied

Estimating the burden of illness in an Ontario community with untreated drinking water and sewage disposal problems.

The Hamilton-Wentworth regional health department was asked by one of its municipalities to determine whether the present water supply and sewage disposal methods used in a community without piped water and regional sewage disposal posed a threat to the health of its residents. Three approaches were used: assessments by public health inspectors of all households; bacteriological and chemical analyses of water samples; and completion of a specially designed questionnaire by residents in the target community and a control community. 89% of the 227 residences in the target community were found to have a drinking water supply that, according to the Ministry of Environment guidelines, was unsafe and/or unsatisfactory. According to on-site inspections, 32% of households had sewage disposal problems. Responses to the questionnaire revealed that the target community residents reported more symptoms associated with enteric infections due to the water supply. Two of these symptoms, diarrhea and stomach cramps, had a relative risk of 2.2 when compared to the control community (p less than 0.05). The study was successfully used by the municipality to argue for provincial funding of piped water.

Diarrhea↗
PubMedDate not supplied

A simple vascular perfusion technique for use in waterfowl.

A simple vascular perfusion technique is described for fixation of avian tissues for study at the light-microscope level. The technique relies on gravity feed of perfusate and gives reliable fixation of the nervous system, liver, kidney, and cardiac and skeletal musculature.

Animals↗
PubMedDate not supplied

Pathology of experimental avian cholera in mallard ducks.

Mallard ducks (Anus platyrynchos) challenged with two isolates of Pasteurella multocida developed either acute or chronic lesions, depending on the isolate of P. multocida and the inoculation dose. Ducks that died acutely of avian cholera had lesions of a hemorrhagic septicemia with widespread vascular damage and focal necrosis in liver, spleen and other organs. Ducks that survived challenge developed chronic lesions in a variety of organs, including brain, lung, air sacs, joints, and eyes. Some surviving ducks sequestered bacteria within these loalized lesions and may be potential "carrier" birds. The possible pathogenesis of P. multocida infection in ducks is discussed.

Animals↗