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Biomedical subjects

B Hughes

Publications and source records attributed to B Hughes.

105 records · Page 6Linked to original sources
PubMed1975

Evaluation of a magnetic bladder pump for neurogenic bladders.

A new bladder pump prosthesis has been designed and evaluated in the normal dog bladder. This encompasses a magnetic pump located subcutaneously with internal silicone catheters from bladder to the urethra. The pump is powered from a hand-held activator which is magnetically coupled externally across the skin. This pump was evaluated in 12 dogs for an average of 65 days and provided adequate emptying of the bladder without alteration of the normal urinary tract or pump malfunction. The potential and limitations of this new approach are discussed.

Animals↗
PubMedDate not supplied

Histomorphometric and biochemical study of osteoclasts at orthodontic compression sites in the rat during indomethacin inhibition.

Prostaglandins affect the number of osteoclasts at compression sites in orthodontic tooth movement. They may also have a role in tooth movement and influence the extent of root resorption. The purpose was to examine the effect of indomethacin on the activity of resident osteoclasts, recruitment of new osteoclasts and root resorption at orthodontic compression sites. Two separate populations of osteoclasts were studied: those resident at the sites after initial appliance activation and those recruited by a subsequent activation. Orthodontic appliances were activated to provide mesially directed forces of 40 g on the maxillary molars of rats. The appliances were activated with the same force after 4 days. The rats were killed at 1, 3, 6 and 10 days after initial activation. Half of the rats were injected with indomethacin. Tooth movement was measured cephalometrically; osteoclast numbers, sizes, numbers of nuclei per osteoclast and root resorption were assessed histomorphometrically; tartrate-resistant acid phosphatase (TRAP) in alveolar bone was measured biochemically. Indomethacin inhibited both initial tooth displacement and that following the delay. It also reduced the increase in osteoclast numbers, total osteoclast surface and alveolar bone TRAP at day 10. It had no effect on the surface area of each individual osteoclast or number of nuclei in each osteoclast. Root resorption increased in both groups but it was enhanced at day 10 in the indomethacin group. These data suggest that orthodontic tooth movement after appliance activation requires the recruitment of osteoclasts to sites of compression and that this is indomethacin-sensitive. Furthermore, indomethacin enhances root resorption at compression sites 10 days after appliance reactivation.

Acid Phosphatase↗
PubMedDate not supplied

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