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Biomedical subjects

B Hopkins

Publications and source records attributed to B Hopkins.

90 records · Page 5Linked to original sources
PubMed1983

Motor behaviour.

Explore the source record for details and available documents.

Child Development↗
PubMed1983

The development of early non-verbal communication: an evaluation of its meaning.

Communication and social preadaptation have interpretative problems in early interaction. Both have strong teleological commitment and are not therefore wholly appropriate. The mother-infant system gradually achieves the hallmark of true teleology largely because the mother acts as if the newborn's foetal-like behaviour had communicative significance. Viewing newborn behaviour as such is compatible with the biological principle of preadaptation which avoids vague assumptions about early behaviour being socially 'prewired'. It is recommended that the mother be given an observer's role as it may lead to a useful methodology for understanding early communication. Studying deviancy in early relationships is also considered.

Child Behavior↗
PubMed1983

Mother-infant dialogue in the first days of life: an observational study during breast-feeding.

The temporal organization of the behaviour of children at risk can exhibit inconsistencies which may impair their adaptation. Seven mother-newborn pairs, selected for neurological and obstetric optimality of the babies, were observed during 2 breast-feedings (2nd after birth and 6th to 9th after birth). During pauses between sucking bouts the behaviours of the two partners were strongly coupled, even in the earlier feedings, which was not the case during sucking bouts themselves. Pauses which contained tactile behaviour were shorter in later feedings than in earlier ones, in contrast to both pauses without tactile behaviour and to bouts. The possible functional relevance of emerging temporal relations between partners' behaviours during breast-feeding is discussed.

Adult↗
PubMedDate not supplied

Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues.

Wilms' tumour (nephroblastoma) is an embryonal neoplasm occurring in hereditary and spontaneous forms. Both types show rearrangements of the short arm of chromosome 11. The germ line of children with the rare inherited triad of aniridia, genito-urinary abnormality and mental retardation carry a chromosome 11 that has a deletion in its short arm (band 11p13) and these children are at increased risk of developing Wilms' tumour. Neonates with the Beckwith-Wiedemann syndrome, in which there may be duplication of the 11p13-11p15 region, are similarly predisposed. In the spontaneous form of the tumour a deletion of the 11p14 band in tumour cells, but not in normal cells, has been reported, and the development of homozygosity for recessive mutations in the 11p region is implicated in the aetiology of Wilms' tumour. In view of these chromosomal rearrangements and because Wilms' tumour is histologically indistinguishable from the early stages of kidney development, we have now examined the expression of genes localized to 11p in Wilms' tumour and human embryonic tissue. In 12 sporadic tumours examined, the expression of the gene coding for insulin-like growth factor-II (IGF-II), localized to the 11p15 region, was markedly increased relative to adult tissues, but was comparable to the level of expression in several fetal tissues including kidney, liver, adrenals and striated muscle. This may reflect the stage of tumour differentiation, but could also contribute to the malignant process, as IGF-II is an embryonal mitogen.

Female↗
PubMedDate not supplied

Evaluation of four maternal smoking questions.

OBJECTIVE: The authors evaluated four questions about maternal smoking during pregnancy for use on birth certificates. METHODS: Question 1 (yes/no format) and Question 2 (trimester-specific design) were tested among 1171 women who delivered at two Kaiser Permanente medical centers in northern California. Responses to Questions 1 and 2 were compared with smoking information provided by participants in telephone interviews conducted during pregnancy. Question 3 (multiple choice format) and Question 4 (month- and grouped month-specific design) were tested among 900 women who enrolled in a statewide prenatal screening program and who delivered in 20 hospitals in four Central Valley counties. Responses to Questions 3 and 4 were compared with mid-pregnancy serum cotinine levels. The authors evaluated the four questions in terms of conciseness, response rate, data accuracy, and type of data requested. RESULTS: Questions 1 and 2 were the most concise. Response rates could not be calculated for Questions 1 and 2. Response rates were 86.0% for Question 3 and 74.2% for Question 4. Sensitivity was 47.3% for Question 1, 62.1% for Question 2, 83.8% for Question 3, and 86.7% for Question 4. The types of data requested by Questions 2 and 4 seem to best satisfy the needs of the broad audience of birth certificate users. CONCLUSIONS: No single question was clearly superior. The authors propose a combination of Questions 2 and 4, which asks about average number of cigarettes smoked per day in the three months before pregnancy and in each trimester of pregnancy.

Birth Certificates↗
PubMedDate not supplied

The effects of castration on the subependymal plate of the rat.

Earlier studies have shown that glial tumours, produced by the intracerebral implantation of chemical carcinogens, originate from the subependymal plate. In the present study the effects of castration on cell number and proliferation in the subependymal region has been investigated as such treatment has been shown to reduce the incidence of gliomata produced by an implanted carcinogen. An age-related reduction in mitotic activity and nuclear density was found in the subependymal plate. Castration produced a consistent reduction in mitotic activity but the nuclear density was unchanged. The results suggest that the reduction in tumour incidence produced by castration cannot be explained simply on the basis of reduced proliferation in the population believed to be at risk and that other, as yet, undefined factors must be involved. In addition, it appeared that there was also no simple relationship between brain growth and cell proliferation in the subependymal plate.

Animals↗
PubMedDate not supplied

Locomoting through apertures of different width: a study of children with cerebral palsy.

Whether children with cerebral palsy (CP) differ from non-handicapped (NH) children was studied, using body-scaled information about the passability of a doorway-like opening. There were 55 children of whom 23 were NH and 32 had CP, the latter consisting of 12 who could stand and walk unaided (CP-Walk) and 20 confined to a wheelchair (CP-Wheel). All groups were divided into two age ranges (5-8 and 9-13 year) and were tested on two occasions separated by an interval of 12 months. On both occasions, testing involved three consecutive tasks: making perceptual (pre)judgments about the passability of an opening varying in width, actually attempting to locomote through the openings (performance), and another round of (post)judgments. Judgments and performance were expressed in terms of absolute and relative outcomes, the latter differing from the former in accounting for differences in body width relative to aperture width. There were two main findings. Firstly, the younger CP-Walk children were the least able to employ body-scaled information in judging aperture width and the older CP-Wheel and NH the most able. Secondly, when performances in passing through the openings were adjusted for differences in body width, all groups had similar outcomes. This findings lends credence to the notion that when action is used in the service of perception, this is beneficial for the visual-spatial abilities of both NH and CP children. The study concludes by pointing out future directions in this type of research as well as some of the clinical implications of the findings.

Activities of Daily Living↗
PubMedDate not supplied

Use of severity-adjusted length of stay to modify physician practice patterns.

OBJECTIVE: To compare inpatient length of stay among physicians by testing a new method for severity adjusting length of stay. DESIGN: A retrospective validation study with prospective follow-up after an intervention. SETTING: A 531-bed community teaching hospital. PATIENTS: Three hundred randomly selected patients from the 30,861 patients discharged in 1990. INTERVENTION: A physician with a significantly prolonged severity-adjusted length of stay was counseled and then monitored for three months. RESULTS: The correlation between the number of comorbidities, complications, and manifestations of disease processes (CCMDPs) was R2 = 0.658, t = 23.96 (p = .001). One physician had an unusually high severity-adjusted length of stay, but lowered it after he was counseled and monitored for three months. CONCLUSIONS: The number of CCMDPs recorded on the hospital discharge abstract can be used as a severity index to adjust a patient's length of stay for illness severity. Using linear regression analysis, a picture of the severity-adjusted length of stay can be derived for physicians. Through counseling and monitoring, individual physicians' lengths of stay patterns may be reduced.

Comorbidity↗