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Biomedical subjects

B Hofman

Publications and source records attributed to B Hofman.

At least 19 recordsLinked to original sources
PubMed2003

[The significance of the pneumatic tourniquet technique for an innovative varicose vein surgery--methods, advantages, risks, danger].

AIM: The systemic effects of the pneumatic tourniquet technique in varicose vein surgery were studied in order to evaluate possible risks and threats. METHODS: 155 patients were included to look at intraoperative changes of cardiovascular parameters and capillary blood and respiratory gases. RESULTS: Whereas the pulse rate showed only an insignificant rise of 3/min, the systolic and diastolic blood pressure increased significantly by 12 and 6 mm Hg resp., after inducing ischemia by roller cuff. After removal of the roller cuff blood pressure decreased by 14 and 9 mm Hg, resp., again. At releasing of the ischemia, pH values drop by 0.02, and the base excess by 0.3 mval/L with operation on one side and 0.5 mval/L in both sides operation. In comparison, the capillary pCO 2 rose by 3 mm Hg and the pCO 2 of the respiratory air by 1 mm Hg in one side operation and 3 mm Hg, resp. in operation of both sides. The pressure in the roller cuff was in the middle only 55 mm Hg above systemic pressure values. CONCLUSIONS: The systemic effects of the tourniquet technique have no clinical relevance. The use of the pneumatic tourniquet (Loefqvist method) is unrestrictedly recommended due to its advantages, such as no intraoperative blood loss, avoidance of post-op haematoma and pain and good immediate cosmetic results.

Acid-Base Equilibrium↗
PubMed2000

Influence of oxygen concentration on argon plasma coagulation-induced tissue damage in isolated pig tracheas.

BACKGROUND: Argon plasma coagulation (APC) is used during bronchoscopy to restore passage of central airways. Concern has been raised about the possibility that elevated oxygen concentration may increase the tissue damage by APC. OBJECTIVE: to examine the extent of tissue damage at different concentrations of oxygen in isolated pig tracheas. METHODS: The APC-induced tissue damage was investigated macroscopically and microscopically in isolated and artificially ventilated pig tracheas at oxygen concentrations of 21, 50, 75 and 100%. RESULTS: There was deep coagulation of all tissue layers reaching the adventitia independent of the oxygen concentration up to 75% O(2). With 100% O(2), only tissue damage increased and combustion occurred. CONCLUSIONS: APC-induced tissue damage in ex vivo pig tracheas was independent of the oxygen concentration relevant for clinical practice.

Animals↗
PubMed1991

Tuberculosis in children: a 13-year follow up of 1714 patients in a Belgian home care centre.

From May 1970 to September 1983, 1714 children with different forms of primary tuberculosis were referred to the paediatric home care centre (Enfants soignés au Foyer, E.S.F.) of the Brussels University Hospital St.-Pierre. They were subdivided in five groups: asymptomatic (33%), symptomatic (28%), dubious tuberculous infections (35%), high-risk contacts (3%) and unestablished diagnosis (1%). They were aged from 10 days to 19 years, and 82% of them were migrants of low socio-economic level. Fifty percent of the symptomatic infections, mainly pulmonary, appeared in children under 3 years of age. An adult source of contamination was identified in 33% of the cases (48% of the symptomatic children). Diagnosis was based on tuberculin screening with a 2IU intradermal test. Gastric aspirates yielded Mycobacterium tuberculosis in 15% of our patients, 11% of them showing resistance to one or more tuberculostatic drugs. Treatment was given to 1359 patients with excellent results. Therapy was shortened during the last 2 years of the study from 12 to 6 months for the asymptomatic patients and from 12 to 9 months for the symptomatic infections. Few complications were observed. Tuberculosis remains a serious cause of morbidity particularly in migrant children. Correct diagnosis and treatment of the disease is very important.

Adolescent↗
PubMed1989

Acute hemodynamic and antiischemic properties of intravenous bepridil in coronary artery disease.

The acute hemodynamic and antiischemic effects of intravenous bepridil (3 mg/kg/5 minutes followed by 1 mg/kg/hour) were studied in 19 patients with coronary artery disease under basal conditions and during 2 identical pacing stress tests 30 minutes before (pace test I) and 15 minutes after (pace test II) onset of infusion. Bepridil immediately decreased coronary and systemic vascular resistance (26 and 17%, respectively). This resulted in a 19 and 21% reduction in left ventricular systolic and mean aortic pressures and a 15% increase in coronary flow and stroke index (p less than 0.05 vs control for each). These vasodilating effects were short lasting, persisting for 5 minutes after the bolus infusion, followed by significant reductions in heart rate (15%) and contractility (10%) and a temporary 46% increase in left ventricular filling pressure. During both pace tests heart rate, contractility, coronary flow and myocardial O2 consumption were comparable. In contrast, bepridil prevented the significant increase in systemic resistance and mean aortic pressure observed during pace test I (11 and 15%, respectively). Subsequently, myocardial O2 demand was significantly less during pacing after bepridil, due to an 11% reduction in left ventricular systolic pressure (p less than 0.05 vs control and pacing test II vs I). This resulted in marked antiischemic effects: normalization of lactate extraction and reduction in ST-segment depression (-14 +/- 7 vs 3 +/- 6% and 0.2 +/- 0.02 vs 0.13 +/- 0.02 mV, respectively, pace test I vs II, p less than 0.05), and in less or no angina in 18 patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1972

Poliomyelitis in the Netherlands 1958-69: the influence of a vaccination programme with inactivated poliovaccine.

The Netherlands is one of the few countries where poliomyelitis vaccination is practised with inactivated vaccine. Vaccinations started in 1957 and since 1962 have been carried out with a diphtheria-tetanus-pertussis-poliomyelitis vaccine according to a fixed schedule. The overall acceptance rate has been over 90%.Since 1957 the poliomyelitis morbidity has decreased by more than 99% in fully vaccinated persons and by 60-80% among nonvaccinated persons. The latter reduction probably resulted from a decrease in the amount of virus circulating after the vaccination campaign had started. The rather unequal distribution of acceptance rates allowed for a more detailed examination, which showed a relation between acceptance rates and morbidity figures. The morbidity pattern is now characterized by a few local outbreaks among nonvaccinated subjects in areas with low vaccination rates, and by the virtual disappearance of the disease in the rest of the country.

Adolescent↗