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Biomedical subjects

B Hoerni

Publications and source records attributed to B Hoerni.

At least 145 records · Page 8Linked to original sources
PubMed1979

Total body irradiation (T.B.I.). Preliminary results of a new technique in 30 patients with hematologic malignancy.

The authors present the preliminary results of a new technique of total body irradiation (T.B.I.) used in 30 patients with hematological malignancy. The schedule proposed is easy to use and reproducible. The clinical and hematologic tolerance is good even for patients having had previous cyclic polychemotherapy and/or large-field irradiation. Low-grade non-Hodgkin lymphomas previously nontreated appear to be the best indication. Further investigations have to be performed particularly to specify the interest of combining T.B.I. and chemotherapy or T.B.I. and radiotherapy in the treatment of non-Hodgkin lymphomas.

Adult↗
PubMed1979

[Induction chemotherapy in high risk breast cancer. Results of a prospective therapeutic study (author's transl)].

The action of an induction chemotherapy was studied in 54 patients with extensive localized tumour. An association of doxorubicin (adriamycin), vincristine and methotrexate were used in five days courses every three weeks. Three to four courses were applied before radiotherapy (minimum of two months of treatment). This chemotherapy gave very good immediate objective responses (87% of the cases), especially for breast tumors which follow an acute course. No adverse effects on the later sequences of the treatment program were observed. The follow up period is too short to establish long term efficacy. Nevertheless, it now seems of value to apply the chemotherapy from the onset of the disease: on one hand it represents a preparatory factor which is probably useful in reinforcing the action of loco-regional treatment; on the other hand it represents the first treatment for these high risk breast cancers, whose prognosis is mainly determined by metastasis.

Antineoplastic Agents↗
PubMed1978

Malignant lymphoplasmacytoid lymphomas. Clinical and evolutive data.

A series of 31 cases of malignant lymphoplasmacytoid lymphomas (excluding Waldenström disease) is analyzed. Two-thirds of the patients initially had localizations elsewhere than in the lymph nodes and presented clinical stage I or II. The median survival is around 4 years and is particularly favorable for stage I and II patients who have received an association of radiotherapy and systematic chemotherapy; the estimated "cure rate" for these patients is around 80%.

Adult↗
PubMed1978

[Immunoblastic lymphosarcomas. Clinicopathological aspects and course. Retrospective analysis of a series of 50 patients (author's transl)].

The immunoblastosarcoma (IB) was preceeded by another pathological state in almost one third of patients. The clinical picture was often very typical, with large inflammatory node involvement. In one third of cases, the initial site of the tumor was not nodal, but in Waldeyer's ring or a non-lymphoid organ. Analysis of topographic extension indicates a weak propensity to dissemination. The tissues which are the more frequent site of secondary invasion were the lung parenchyma and the subcutaneous tissue. The course was rapid, almost always fatal. Only a combination of radiotherapy and chemotherapy would seem capable of eradicating the tumour. On the basis of all these characteristics, the IB has a special place alongside other non-Hodgkin lymphomas and they may be individualised histologically. These cases are in general in agreement with the little data published in the literature.

Adult↗
PubMed1978

Ocular toxoplasmosis and Hodgkin's disease: report of two cases.

Isolated ocular toxoplasmosis developed in two patients with Hodgkin's disease. The diagnosis was made by ophthalmoscopy of the fundus, serologic tests, and evolution. This raises the possibility that Toxoplasma infection and the localization of retinochoroiditic lesions on the macula could be the results of the immunosuppression associated with Hodgkin's disease.

Adolescent↗
PubMed1978

BCG in the immunotherapy of non-Hodgkin's malignant lymphomas: preliminary results of a controlled trial.

Thirty-three patients exhibiting non-Hodgkin's malignant lymphoma with one or more criteria of poor prognosis and in whom complete remission had been induced by an association of chemo + radio + chemotherapy were randomized to either receive BCG or no further treatment. The present results indicate that BCG may be useful to maintain remission in about one-third of the patients, but these results are not yet significant.

Antineoplastic Agents↗
PubMed1978

[Induction chemotherapy of non-Hodgkin malignant lymphomas. Results of a controlled trial comparing two quadruple associations (author's transl)].

Two types of chemotherapy have been compared in a randomized trial to treat non-Hodgkin malignant lymphomas. 66 patients were included in this study, but only 40 were evaluable after a histologic review of all cases. Treatment were an association of cyclophosphamide, vincristine, prednisone and doxorubicine or VM 26. Patients received only one induction chemotherapy course during 15--20 days. Results were evaluated immediately at the end of the course. Side-effects were mild. Efficacy was about the same with the two protocols: 35 patients out of 40 experienced a remission of more than 50% (among them 8 experienced a complete remission). These results are better than previous one obtained with cyclophosphamide, vincristine and prednisone only. It is concluded that this type of treatment is well tolerated, quickly efficient and useful before treating patients with radiotherapy or long-term chemotherapy.

Antineoplastic Agents↗
PubMed1978

Hodgkin's disease treated by chemotherapy and large field irradiation. Hematologic effects.

The hematologic effects of combined chemotherapy and irradiation were analyzed in 70 patients with Hodgkin's disease stage I and II. The schedule used was as follows: one cycle of 15--21 days of chemotherapy immediately followed by irradiation, including mantle and lumboaortic fields. After a rest of one month, another cycle of the same chemotherapy was applied. The erythrocytes varied slightly; the leukocytes decreased during chemotherapy and were stable or increased slightly during irradiation. Platelets decreased slightly during chemotherapy and more markedly during irradiation. No major side effects were observed, and the regimen appeared well tolerated.

Adolescent↗
PubMed1978

[Anticancer chemotherapy: practical management and medical coordination (author's transl)].

The authors have studied the conditions of application of a protocol of palliative chemotherapy in breast cancers for the first 100 patients undergoing this protocol. The overall management of the treatment has been satisfactory. The medical team from the cancer center has directed the treatments; however, their participation, although substantial has been limited. The participation of other doctors, especially general practitioners, has been important and of good quality. The coordination between the various doctors has been almost always satisfactory. The authors stress the positive aspects of this study: the protocol has been respected in the majority of the cases; the duties have been well distributed among the various participating doctors; good medical cooperation leaves only a few minor details which could be improved. These results encourage the continuation of an approach whereby the general practitioner participates fully with the oncologic team in patient management and cancer control.

Adult↗
PubMed1977

The strategy of treatment of Hodgkin's disease.

The treatment of Hodgkin's disease necessitates, in most cases, an association of radiotherapy for the macroscopic tumoral masses and chemotherapy for the cells generalized in the organism. Whenever a systematic chemotherapy is associated with radiotherapy, a precise staging topography with laparotomy is useless. The current therapeutic trials should seek methods to lighten these treatments by determining the best equilibrium between the two principal methods and by specifying the ventual place of immunotherapy. The present possibility of curing more than three-fourths of Hodgkin's patients incites us to look for means of reducing the treatment and its inconveniences for the curable forms, and search for more active or tolerable treatments for the uncurable forms.

Antineoplastic Agents↗
PubMed1977

[Cancer information of the general practitioner].

Inquiries among more than 1 000 general practitioners in the South-West area of France permitted us to precise their needs and wishes about information in the cancer field. The aim of these data is to adapt in a better way the teaching for students and graduates on the base of a close collaboration between general practitioners and cancer specialists.

Antineoplastic Agents↗