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Biomedical subjects

B Hirsch

Publications and source records attributed to B Hirsch.

66 records · Page 4Linked to original sources
PubMed1984

T-cell subpopulations in head and neck carcinoma.

Peripheral blood T-cell subpopulations were quantitated with monoclonal antibodies in a group of 27 patients with biopsy-proved squamous cell carcinoma of the head and neck. Abnormal quantitative relationships between helper/inducer T cells (Th) and suppressor/cytotoxic T cells (Ts) were encountered in many patients. Short-term follow-up of these patients did not demonstrate a correlation between these immune parameters and clinical course. Longer follow-up and expansion of the data base will be necessary before a determination can be made of the value of quantitative T-cell subpopulation analysis relative to its use as a prognostic indicator in patients with head and neck cancer.

Antibodies, Monoclonal↗
PubMed1983

Immunostimulation of patients with head and neck cancer. In vitro and preliminary clinical experiences.

The development of malignancy is theorized to be from failure of the immunosurveillance system. Prostaglandins (PGs), synthesized by a mononuclear cell, tumor cell, or both, enhance inhibition of competent cellular immunity. Ten patients with terminal squamous cell carcinoma of the head and neck were treated with indomethacin, and inhibitor of PG synthesis. Two patients had a dramatic response; however, an in vitro assay and a derived-stimulation index did not correlate with the clinical response. A review of the literature and future directions are discussed.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

22q11.2 microdeletions in adults with familial tetralogy of Fallot.

PURPOSE: To determine the incidence of 22q11.2 microdeletions in the adult survivors of correction of tetralogy of Fallot who have familial congenital heart disease. METHODS: Patients who had survived a correction of tetralogy of Fallot between 1954 and 1974 and had affected family members were identified during a study of these long-term survivors. Fluorescence in situ hybridization analysis was performed using both the N 25 (Oncor) and TUPLE1(VYSIS) probes, mapped to 22q11.2. RESULTS: One of 18 (5.6%) patients had a microdeletion within 22q11.2, including both N25 and TUPLE1. CONCLUSION: 22q11.2 microdeletions involving TUPLE1 and/or N25 are present in a minority of adults with familial tetralogy of Fallot.

Adult↗