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Biomedical subjects

B Heymer

Publications and source records attributed to B Heymer.

153 records · Page 9Linked to original sources
PubMedDate not supplied

Resistance of gnotobiotic nude mice to Listeria infection.

Unlike the acute and short-term course of experimental listeriosis in phenotypically normal (nu/+) mice, Listeria monocytogenes infection in conventionally raised athymic Nude mice results in chronic inflammation with persistence of bacteria and lesions in the internal organs such as liver and spleen. Although it could be shown that germfree Nude mice had no intestinal microbial flora and lacked measurable serum immunoglobulins, neither the course nor the histomorphology of experimental listeriosis differed significantly from that of their conventionally raised littermates. The results indicate that the typical response of Nude mice to Listeria infection is primarily determined by inborn factors and not by prior antigenic stimulation.

Animals↗
PubMedDate not supplied

A fatal infection with Alternaria alternata and Aspergillus terreus in a child with agranulocytosis of unknown origin.

Alternaria alternata and Aspergillus terreus were isolated from cutaneous nodules in a 5-year-old girl with agranulocytosis of unknown origin. Histopathological examination supported the diagnosis of an infection with two opportunistic moulds. Aspergillus terreus was also isolated from the secretions of the maxillary sinuses of the patient. In spite of antimycotic therapy, the child eventually died from respiratory failure.

Agranulocytosis↗
PubMedDate not supplied

[Cytostatic-induced stomatitis].

45 patients with oral cancer preoperatively received regional intraarterial chemotherapy (RIAC). All patients developed stomatitis or glossitis limited to the region of cytostatic perfusion. Between 1 and 19 days (median 4 days) after RIAC the tumor was removed by hemiglossectomy, partial resection of the floor of the mouth etc. The tissue alterations induced by chemotherapy in these surgical specimens were analyzed histomorphologically. Stomatitis due to RIAC was characterized by necrosis, ulceration and severe epithelial dysplasia of mucous membranes. Approximately 2 weeks after chemotherapy both the inflammatory changes and the dysplasia had disappeared completely. The differences between spontaneous premalignant dysplasia of the oral cavity and dysplasia induced by RIAC are discussed.

Adult↗
PubMedDate not supplied

[Histomorphology of inflammation].

Progress in biochemistry of inflammation, particularly in the identification of mediators of inflammation, has considerably deepened our understanding of the histomorphology of inflammatory lesions. In surgical pathology, the traditional histologic differentiation between specific and non-specific inflammation still plays a certain role. This differentiation, on the other hand, has lost significance since it became evident that specific inflammatory reactions, such as epithelioid cell granuloma formation, can be observed in diseases of completely different etiology. Consequently, the histological picture does not reflect the activity of a particular etiologic agent but rather images the action of mediators of inflammation. Which mediators are released depends not only on the inducing agent but also on numerous other factors. This holds true for specific as well as non-specific inflammation and also for immunopathologic (allergic) reactions. In most instances the modulating effect of the fine structure of tissues (e.g. capillary angioarchitecture) on the intensity, type and course of inflammatory processes is covered by other predominating influences. The most important new aspect in the histomorphology of inflammation is the possibility--nowadays--of interpreting histological patterns of inflammation in terms of known pathomechanisms.

Animals↗