Cryosurgery (in situ freezing) had been efficaciously employed for the treatment of malignant neoplasms. In situ freezing of a number of tissue has been demonstrated to constitute an antigenic stimulus (comparable to that obtained through the parenteral administration of antigen) capable of generating a specific immunologic response against autologous antigens of the frozen tissue, ergo, cryostimulation, However, if cryosurgery is to be employed not only for ablation of tumor, but also as a possible means of engendering an immunologic response to tumor (primary, as well as secondary, i.e., metastases), ergo, cryoimmunotherapy, several factors must be given careful consideration. It is with the further elucidation of these factors and the continuing endeavor to establish criteria for evaluating the candidacy of the cancer patient for cryoimmunotherapy and their postoperative responsiveness that have been reviewed, assessed and updated.

Antibody Formation↗

PubMedDate not supplied

The significance of the imprint cytology in breast biopsy diagnosis.

Tissue biopsies of the breast with and without carcinomas were examined simultaneously by intraoperative histology and imprint cytology. In 95 per cent of the cases there was a good agreement between the histologic and cytologic diagnoses. The reliability of the imprint cytology was tested in some complicated cases such as proliferating fibroadenomas, pseudoinvasive adenosis and carcinomas. In 20.2 per cent of the cases with carcinoma, the tumor cells showed peculiar intracytoplasmic inclusions, whereas such inclusions were found only in 0.43 per cent of the biopsies of mammas without carcinoma. Their morphological variations and the histochemical pattern are discussed. The results have demonstrated that simultaneous cytologic examination of unfixed mamma biopsies can be a good screening method and that the intracytoplasmic inclusions may be an especially helpful histopathologic feature in the diagnosis of breast cancer.

Biopsy↗

PubMedDate not supplied

Comparison of suspicious and positive colposcopic, cytologic and histologic findings in the uterine cervix.

One hundred thirty-five cases of suspicious or positive colposcopic or cytologic findings were histologically analyzed. In cases of colposcopically detectable atypical changes or suspicious findings as well as of cytologic dysplasias or carcinomas, the histologic diagnoses were almost the same. The results demonstrated that colposcopy and cytology with a quick staining method are of value. Biopsy can quickly follow in cases of suspicious findings.

Biopsy↗