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Biomedical subjects

B Hellström

Publications and source records attributed to B Hellström.

At least 19 recordsLinked to original sources
PubMed1989

Clinical, HLA, and roentgenological follow up study of patients with juvenile arthritis: comparison between the long term outcome of transient and persistent arthritis in children.

Fifty two patients with juvenile chronic arthritis (JCA) and 22 patients with arthritis of short duration (transient arthritis, TA) were studied in a follow up investigation. Nineteen (37%) of the patients with JCA had peripheral arthritis or sequelae in the form of contractures at follow up, and in addition one patient was treated with corticosteroids. In contrast, only one (5%) of the 22 patients with TA had peripheral arthritis at follow up. Back pain or limitation, or both, was registered in many of the men. Sacroiliitis, verified by x ray, was often found both in JCA (39/46, 85%) and in TA (16/21, 76%). For JCA an association was confirmed with HLA-A2 and HLA-DRw8 and a negative association with HLA-DR4, and in pauciarticular JCA, in addition, a decrease of DR7. A new finding was a low prevalence of HLA-B27 in women with JCA and grade 3 or 4 sacroiliitis (2/14, 14%).

Adolescent↗
PubMed1982

The traction reaction in infancy-clinical and electromyographic study of normal infants.

The traction reaction was studied in 23 normal infants on 45 occasions at ages ranging from 2 weeks to 12 months. The distribution of the developmental phases of the reaction to some extent differed from that expected from age according to the description of Vojta (1976). EMG recordings from 15 trunk and leg muscles were obtained on 37 occasions from 20 of the infants. Six types of EMG activation pattern during traction were observed in different overlapping age periods from 1 month to 12 months. From these patterns, four well separated stages of motor development were distinguished. They were as follows: 1) No EMG activity related to traction. 2) Trunk flexor activation with weak or irregular activation in leg muscles. 3) Reciprocal activation in trunk flexor and extensor muscles combined with strong co-activation of the leg muscles, and 4) Trunk muscles activated as in stage 3, but the coactivation in leg muscles abolished and gradually followed by functionally adequate activation in some of the leg muscles.

Electromyography↗
PubMed1980

Influence of phenobarbital on the psychomotor development and behaviour in preschool children with convulsions.

Eleven preschool children with febrile convulsions or epilepsy were started on phenobarbital. Before treatment was started and at regular intervals after the onset of medication up to one year psychological tests were applied and the behaviour of the children analyzed. The plasma levels of phenobarbital were recorded. A transient deterioration of fine motor functions and behavioural disturbances were found in most children during the first weeks and months. The problems subsided thereafter and at one year follow up the drug-induced changes had disappeared. The need for extended studies is underlined.

Child↗
PubMed1979

Is beta-receptor blockade of value in continence training of children?

The relaxation of the outlet region of the bladder is subserved by beta-adrenergic receptors. It is conceivable, therefore, that inhibition of beta-adrenergic function should be of value as part of a continence training program in patients with neurogenic bladders. This hypothesis was tested in a series of thirteen children with spinal lesions. A double-blind, cross-over study of alprenolol versus placebo was performed during conventional continence training. The number of "dry periods", however did not differ during the alprenolol and placebo periods. One reason for the lack of clinical effect may be that the drug simultaneously blocked the beta receptors in the corpusfundus of the bladder, thereby decreasing the volume capacity.

Adolescent↗
PubMed1976

Prophylaxis in urinary tract infection in children with myelomeningocele.

In 39 infants and children with myelomeningocele, no lower incidence of urinary tract infection was obtained by a trial of prophylaxis treatment with nitrofurantoin. Instead, nitrofurantoin-resistant strains appeared in some children, with the accompanying higher risk of re-infection.

Adolescent↗
PubMed1976

Results of treatment in myelomeningocele.

A follow-up study was made in 48 surviving children with myelomeningocele, the material being derived from a time when all infants were operated upon in the newborn period without primary selection. The follow-up revealed several children with severe physical handicap, whereas relatively few were both physically and intellectually handicapped. The results were compared with two earlier published studies of which one from Sheffield comprised cases where selection had not been applied and the other from Edinburgh in which certain criteria had been set up as contra-indications to early closure of the lesion. The effect of a hypothetical selection applied to the Swedish material is discussed. It is recommended that a uniform system of assessment in grading of handicap is applied to facilitate a comparison between different follow-up investigations.

Child↗
PubMed1975

Plasma levels of diazepam after parenteral and rectal administration in children.

Plasma levels of diazepam and N-desmethyldiazepam were investigated in 19 children by a gas chromatographic method permitting the use of capillary sample. Intravenous administration was studied in 3 children and the plasma level curves showed a rapid decline during the first hour. Absorption and elimination after rectal administration of a solution in 16 children were similar to those after intramuscular administration. Diazepam given by suppository to 5 children gave much lower plasma levels and delayed time to peak levels. Recurrence of seizures in 2 children indicated that the anticonvulsants plasma level was of the order of 150 to 200 mug/liter. No significant side effects were observed. Thus rectal administration of a solution of diazepam is a practical method to arrest convulsions in children.

Child↗
PubMed1975

Heat vasodilatation of the rat tail.

The vasomotor response of the tail of the albino rat to total-body heating and cooling was studied by skin-temperature recording and plethysmography with the tail at 25 degrees C air temperature. Tail vasodilation started at core temperatures lightly above 37 degrees C and increased to a core temperature up to about 39 degrees C. During cooling of warm rats, tail vasoconstriction started at significantly higher levels of core temperature than the values at which vasodilation appeared when the rat was warmed.

Animals↗