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Biomedical subjects

B Hazaz

Publications and source records attributed to B Hazaz.

42 records · Page 3Linked to original sources
PubMed1980

Identification of T & B lymphocytes on skin sections from patients with lymphoproliferative disorders of the skin.

The T & B lymphocytes in frozen sections of skin obtained from patients with various lympho-infiltrating disorders of the skin were identified using an immunofluorescent technique. Anti T-lymphocytes serum was used as a T marker and anti Ig GMA serum and HL-B alloantigens as B markers. The method confirmed to be efficient in preliminary experiments. Specimens were obtained from patients with lymphocytic infiltration of the skin (LIS), lymphadenosis benigna cutis (LBC), lymphoma cutis (LC) and mycosis fungoides (MF). In LIS and LBC the dominant cell was found to be the T lymphocyte, suggesting that a local immune reaction of the cell mediated type may play a role in their etiology.

B-Lymphocytes↗
PubMed1980

Autoimmune antibodies after splenectomy.

Sera of 41 splenectomized subjects were tested for presence of autoantibodies by the indirect immunofluorescent method. 11 of them (26%) revealed the presence of one or more types of autoantibodies. Antiheart antibodies were the most common type (9 subjects). The incidence of antibodies was higher in the subjects splenectomized for trauma than in those who underwent elective splenectomy (39 and 25%, respectively). There was no significant difference between the subjects with positive and negative results with respect to mean age at examination, but the positive results tend to occur more frequently in those who underwent splenectomy at younger age. None of the subjects with any type of antibodies suffered from autoimmune disease. Although it is still impossible to evaluate the clinical importance of these findings, they suggest that splenectomy may disturb the regulatory processes in the immune system. We postulate that this is due to the reduction of the number of suppressor T cells for which the spleen is a major pool.

Adolescent↗
PubMed1979

Lupus nephritis. Electron-dense and immunofluorescent deposits and their correlation with proteinuria and renal function.

Thirteen patients who had systemic lupus erythematosus were studied for the purpose of correlating the findings of light and electron microscopy and immunofluorescent studies with renal function and the presence of proteinuria. Subendothelial deposits of electron-dense material were found in all biopsy specimens, whereas mesangial and subepithelial deposits were not always present. IgG and beta 1c were constant findings in the glomerular membrane. The seven patients who were found to have extensive subendothelial deposits had moderate to massive proteinuria, and four of these patients had decreases in renal function. Most of the patients who had smaller subendothelial deposits had slight or insignificant proteinuria. Massive subendothelial deposits were mainly found in specimens showing histologic evidence of active lesions. Correlation was also found between proteinuria and the overall amount of deposits and their distribution. The prognosis was dependent on the severity of subendothelial deposits, the overall amount of deposits, and the morphologic form of lupus nephropathy.

Adolescent↗
PubMed1979

Immunofluorescent and electron-microscope findings in the uninvolved skin of patients with systemic lupus erythematosus.

Specimens of uninvolved skin of 20 patients with systemic lupus erythematosus (SLE) were studied using a direct immunofluorescent technique (IF) and the electron microscope (EM). EM examination revealed deposits of electron-dense material below the basal membrane, among collagen fibers in the dermis and in the walls of dermal blood vessels. The direct IF technique revealed granular "band" deposition of immunoglobulins and complement at the dermo-epidermal junction as well as granular deposition in the walls of blood vessels. There was close correlation between the IF and EM findings. It was concluded that the EM is of particular value in precisely delineating the location and ultrastructural pattern of skin deposits. The IF technique is not limited in relation to the size of area which can be studied and makes it possible to identify the specific immune fractions present. It is suggested that these two methods are mutually complementary in providing information concerning the deposition of immunoglobulins taking place in the uninvolved skin of SLE patients.

Adult↗
PubMed1978

The correlation between the antibody titers in sera of patients with Pemphigus vulgaris and their clinical state.

Immunofluorescent antibodies against the intercellular material of the malpighian layer were detected in the sera of 22 of 24 patients suffering from pemphigus vulgaris. A clear-cut agreement between pretreatment antibody titers and the severity of the clinical manifestations was established only with the extreme values, i.e., patients without antibodies were among the mildest cases while the highest titers were found exclusively among the most severe cases. There was a considerable overlapping of all 3 states of the disease--mild, moderate and severe--in the range of the intermediate titers. On the individual level, 20 of the 24 patients showed a positive correlation between steroid-induced clinical improvement and a fall in the antibody titer. Conversely, in some cases, an exacerbation of the clinical state was associated with a rise in antibody titer. The results of this investigation indicate a positive correlation between the immunological findings and the clinical activity of the disease.

Adult↗