Biomedical subjects
B Harty-Golder
Publications and source records attributed to B Harty-Golder.
Beware the hand in the till.
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Hospital risk-management conflicts.
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Risk management for individual practices.
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Primary lymphoma of the central nervous system. Computerized tomography scan characteristics and treatment results for 12 cases.
A retrospective analysis of 12 patients with primary central nervous system non-Hodgkin's lymphoma seen from 1958 to 1980 was carried out with emphasis on diagnostic evaluation and treatment results. Computerized tomography (CT) scans were found to be the most valuable diagnostic tool both for initial evaluation as well as follow-up. Characteristic CT scan features were identified and are discussed. Three patients had a history of previous immunosuppression; two had preceding and concurrent uveitis. Nine of the 12 patients were treated primarily with radiation therapy. Three patients were diagnosed at autopsy and had not received definitive therapy. Size of lesion proved to be the most important prognostic factor and appeared to be related to location. Gross total excision of tumor did not appear to improve survival. Two patients were alive with no evidence of disease at 38 and 48 months, respectively. Recurrences were noted from 1 to 33 months after diagnosis (median, 14 months), suggesting the advisability of long-term follow-up prior to presumption of cure. From these results and a review of the literature, possible treatment approaches are presented.
Burkitt's lymphoma presenting with gastroduodenal involvement. Endoscopic description and review of the literature.
A 16-yr-old man with Burkitt's lymphoma presented with 1 mo of epigastric pain and was found at endoscopy to have gastric ulcers with nodular borders and a duodenal mass lesion. Laparotomy revealed a large pelvic mass and tumor involvement of the stomach, small bowel, and retroperitoneal lymph nodes. Presentation with gastroduodenal disease is unusual, and the endoscopic features of Burkitt's lymphoma have not been previously reported. Gastrointestinal involvement with Burkitt's lymphoma is reviewed, and characteristics of the North American and African varieties are contrasted.
Rash and eosinophilia in a 23-year-old man.
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Lymphomas and their expression in peripheral blood.
Circulating malignant cells may be demonstrated in patients with lymphoma. Whereas Hodgkin's disease rarely if ever becomes leukemic, the non-Hodgkin's lymphomas often express varying numbers of neoplastic cells in peripheral blood. The incidence of leukemic manifestation in these patients correlates with the histologic subtype of the lymphoma. Pure morphologic examination of neoplastic circulating cells may not be sufficient to recognize the presence of lymphoma or to diagnose its type. The application of modern laboratory techniques such as enzyme histochemistry, cell surface markers and cell kinetics, may be very helpful in demonstrating the presence of circulating lymphoma cells in recognizing their type.
Percentage of cells in the S phase of the cell cycle in human lymphoma determined by flow cytometry.
The percentage of cells with S phase DNA content (S cells) was determined by flow cytometry in cell suspensions obtained from 27 patients with non-Hodgkin's lymphomas. DNA was measured in ethanol-fixed cells stained with propidium iodide after RNase treatment. Cells from 17 samples were also exposed to [3H]-thymidine and labeling indices were determined. An excellent linear correlation was observed between the percentage of S cells calculated by flow cytometry and the labeling index (r = 0.95). To determine the relationship between the percentage of S cells and the clinical behavior of the tumors, the survival of the 27 patients was analyzed. None of the patients was undergoing antineoplastic therapy at the time of the study. The patients were separated into 2 groups according to the percentage of S cells calculated by flow cytometry: those with less than 5% S cells and those with higher than 5% S cells. Clinical follow-up ranged from 5 to 20 months. While 7 of 12 patients with tumors containing more than 5% S cells have died of lymphoma (median survival, 9 months), there has been only one death from lymphoma among 15 patients with tumors containing less than 5% S cells. The difference in survival between these two groups is statistically significant (P = 0.01).
Drugs, alcohol and liability.
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