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Biomedical subjects

B Hall

Publications and source records attributed to B Hall.

172 records · Page 10Linked to original sources
PubMedDate not supplied

Renal metabolite concentrations and the activities of glutaminase and glutamate dehydrogenase during recovery from metabolic acidosis in the rat.

Metabolite content was determined in freeze-clamped kidneys to elucidate the rate-controlling steps which are responsible for the inhibition of renal ammoniagenesis that occurs when rats are allowed to recover from metabolic acidosis. After 1 day of recovery from acidosis there were increased renal contents of glutamate, glutamine, alpha-ketoglutarate, citrate, lactate, and malate. The calculated cytoplasmic concentration of oxaloacetate was also increased. The renal content of phosphoenolpyruvate, 3-phosphoglycerate, and ammonia decreased during recovery. No changes were observed in the renal content of the adenine nucleotides or of inorganic phosphate. The activities of phosphate-dependent glutaminase and glutamate dehydrogenase were elevated even after 7 days of recovery although the renal contents of glutamate and alpha-ketoglutarate had returned to control levels by this time. The changes in oxaloacetate and phosphoenolpyruvate are consistent with the fall in the activity of phosphoenolpyruvate carboxykinase observed by Parry and Brosnan. The increased levels of alpha-ketoglutarate and of glutamate are considered to be a consequence of a primary change in the activity of alpha-ketoglutarate dehydrogenase. These results are discussed in the light of the known effects of these metabolites on glutaminase activity and on glutamine entry into renal mitochondria.

Acidosis↗
PubMedDate not supplied

Post-registration education in three fields of clinical practice.

This paper describes some empirical findings about the take-up of post-registration education by a substantial sample of clinical practitioners in three fields of practice--mental illness nursing, mental handicap nursing and midwifery. Some implications of the results are discussed in the context of the UKCC PREPP Report recommendations, as a contribution to the current debate about their implementation.

Education, Nursing, Continuing↗
PubMedDate not supplied

An innovative method of administering i.v. medications to children.

Intravenous medications, especially antibiotics, should be infused in a timely fashion, with minimal irritation to the vessel, with the least chance of infiltration, and without causing fluid overload. Nurses at one institution were concerned that the method they were using was not fulfilling these desired outcomes. Medications were not consistently being administered within the appropriate time frame (usually 30 to 60 minutes) and the possibility of fluid overload existed. Time that nurses spent administering and checking on the medication was excessive. After reviewing alternative methods, nurses implemented a method that uses syringe tubing. Advantages, disadvantages, and a guideline for use are described.

Child↗
PubMedDate not supplied

Loss adjusters.

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Aftercare↗