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Biomedical subjects

B Hagen

Publications and source records attributed to B Hagen.

At least 73 records · Page 4Linked to original sources
PubMed1987

Single and repeated dose pharmacokinetics of thio-TEPA in patients treated for ovarian carcinoma.

Triethylenethiophosphoramide (thio-TEPA) pharmacokinetics were studied in 15 patients being treated for epithelial ovarian carcinoma. Unchanged thio-TEPA was assayed in serum and urine by means of a gas chromatographic procedure. No accumulation or alteration of the pharmacokinetics occurred during therapy, which was continued for up to 7 months with biweekly administrations of 20 mg, after two initial loading courses with 20 mg daily for 3 consecutive days 2 weeks apart. No significant difference in the pharmacokinetics between i.m. and i.v. administration was demonstrated. However, three patients showed a reduced absorption ability from the i.m. injection site to the systemic circulation and an apparent increase in the elimination half-life (3.86 +/- 0.97 h), which could be of clinical relevance. A first-order elimination process with a short elimination half-life (approximately 1.5 h) was demonstrated for thio-TEPA in all patients after i.v. administration. The apparent volume of distribution averaged 50 1. The renal clearance was below 1% of the total-body clearance, which averaged 412 ml/min. The urinary excretion of unchanged thio-TEPA was complete within 8 h after administration, with an average urinary recovery of 0.14% of the dose. Calculation of the area under the serum concentration vs time curve revealed wide variation between patients (range 517-1480 ng/h ml-1), indicating the need for drug monitoring during therapy.

Adenocarcinoma↗
PubMed1987

The binding of thio-TEPA in human serum and to isolated serum protein fractions.

Binding of triethylenethiophosphoramide (thio-TEPA) in serum from healthy individuals and from cancer patients and its binding to isolated serum protein fractions were studied by equilibrium dialysis. A drug-protein binding in the order of 10% was demonstrated in serum, with little interindividual variation. The protein binding of thio-TEPA seemed to be restricted to albumin and lipoproteins, with the greatest affinity to albumin. The previously reported selective binding of thio-TEPA to gamma globulin was contrary to our findings. The almost insignificant degree of serum protein binding of thio-TEPA indicates that the drug is well suited for use in cancer drug combinations.

Blood Proteins↗
PubMed1986

[Vascular changes in sporadic ergotism. Epidemiology, pathogenesis, clinical picture and diagnosis with particular consideration of angiographic documentation].

Whereas the epidemic form of ergotism has been rare in the 20th century, the sporadic form has a wide distribution as a consequence of therapy with ergot-derivative drugs. Favourable prognosis of the condition, with complete recovery from the ischemic peripheral circulatory disorders can be obtained by early diagnosis. Precise evaluation of the history, with recognition of treatment of migraine headache or postpartum hemorrhage with ergot alkaloids, can be determinative in diagnosis. The specific pattern of the angiographic findings, as we saw it in 6 cases within the last 4 years, decisively confirms the diagnosis. We could demonstrate thread-, thorn- and hour glass-like narrowing of the vessels, due to spasm. Total occlusion with the development of collaterals may occur, but we saw no thrombus formation. The stenotic arterial segments had smooth margins. The distribution of the involved arteries was more focal than generalized and more peripheral than central. In two cases spasm could be abolished immediately by a pharmaceutical (i.a. injection of tolazoline) or by anesthetic procedures (halothane). The phenomenologic data, together with the complete reversal of the circulatory ischemic disorders after therapy (particularly the absolute ban of ergots) in most cases, is so specific that other diseases of ischemic nature (emboli, arteriosclerosis, Buerger's disease, fibromuscular hyperplasia) can be excluded.

Adult↗
PubMed1986

[Isolated arteriosclerotic aneurysms of the iliac arteries. Clinical picture, diagnosis and therapy with special reference to x-ray findings].

Isolated aneurysms of the iliac arteries (IA) represent a distinct clinical entity and must be differentiated in this regard from abdominal aortic aneurysms (AA). They may be well characterized within the spectrum of aneurysmic diseases by their localization and their close topographical relationship to neighboring organs. As they cannot be palpated as well as infrarenal AA, they are prone to develop to a considerable size without producing clinical symptoms. The difficulties in diagnosing an IA can be attributed to its relationship with the urogenital, the gastrointestinal and neuromuscular systems as well as with the large veins in the depth of the pelvis. The prognosis can be considered less favorable than that of other AA as iliac structures are involved and the evolution of the process is more advanced at the time of diagnosis. Four cases of arteriosclerotic IA are presented. They demonstrate the specific nature of the disease at different stages of evolution, characterized by clinical course and complications. It must be emphasized that distinct, staged imaging techniques should be used, applying conventional and modern radiological procedures, according to the urgency of the envisaged surgical approach.

Aged↗
PubMed1985

[Systematic and local reactions during phlebography of the leg with special reference to postphlebographic complications. Randomized, prospective, intraindividual double-blind study of iopamidol and ioxithalamate (250 mg I/ml) using the 125I-fibrinogen test: II].

The rate of positive 125I-fibrinogen accumulations after typical ascending phlebography was significantly less (9/40 = 23%) with iopamidol compared with ioxithalamate (16/40 = 40%). The iodine content of the contrast media used in this intraindividual study (40 patients) was 250 mg/ml. With the 125I-fibrinogen uptake accepted as a method of reference, the clinically observed postphlebographic symptoms of thrombophlebitis were false positive in 1/6 and false negative in 3/4 of the cases. These incidences were registered for both contrast media. With the lowered iodine content (250 mg/ml), too, pain reactions were seen in approx. 50% during the injection of the ionic agent, but in none of the cases using the non-ionic agent. Not one of the commercial contrast media can be regarded as "ideal" at this time. Nevertheless, it can be concluded, that non-ionic contrast media with iodine content of 250 mg/ml are highly effective in preventing acute and delayed reactions. Moreover, this concentration seems to be adequate for optimal imaging in phlebography.

Clinical Trials as Topic↗
PubMed1984

Clinical and radiologic aspects of Buerger's disease.

Buerger's disease (BD) is an entity with distinct clinical and pathologic aspects, including etiologic factors, pathogenesis, histology, clinical presentation, course, and prognosis. Comprehensive angiographic studies support the definition of the disease's evolution, provide information about distribution patterns (i.e., bilateral, upper and lower extremities, involvement of trunk arteries), aid in choosing "hot spots" for biopsies, and determine preoperative technical considerations in selection of bypass surgery candidates. In a series of 44 patients with BD, we endeavored to record the frequency of distribution and progression of various stages of disease as well as document the angiographic signs that are commonly accepted as typical of or specific to BD. Characteristic angiographic patterns of the disease are: corkscrew-shaped collateral vessels, cutoff type vascular occlusions, vessels with smooth-lined lumina in non-involved arteries and discontinuous, segmental involvement of affected arteries and veins. Results of pharmacoangiographic functional studies of circulatory disorders appear to cast doubt on the supposed specificity of phenomena such as standing-wave pattern and vasospasm in BD.

Adult↗
PubMed1984

[Systemic and local reactions in leg phlebography with special reference to iodine-containing contrast media. Randomized, prospective, intraindividual double-blind study using iodine-containing contrast media of different osmolarity and iodine concentration. I].

Iopamidol, a non-ionic, tri-iodinated radiographic contrast medium, was superior to the ionic substances ioxaglate, ioglicinate and ioxitalamate in the ascending phlebography. In 180 examinations on 90 patients (report I), which were carried out intraindividually by double blind technique, distinct differences were recorded in particular at pain registration. Since iopamidol was well tolerated in nearly all cases, pain was registered in 10% in ioxaglate, in 22% in ioglicinate and in 37% in ioxitalamate. Anaphylactoid reactions had been observed in one case (1.1%) with iopamidol, in 7% with ioglicinate, in 10% with ioxitalamate and in 17% with ioxaglate. The low incidence of clinically manifest postphlebographic thrombophlebitis and deep venous thrombosis was surprising. In no case was deep venous thrombosis seen after the application of low-osmolar substances, whereas transitory superficial vein irritations could be observed more frequently (10% in iopamidol and 21% in ioxaglate). In ioglicinate as well as in ioxitalamate one deep vein thrombosis and in 10% resp. 30% superficial thrombophlebitis were recorded.

Contrast Media↗