Substitution of sodium acetate for sodium bicarbonate in the bath fluid for hemodialysis.
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Biomedical subjects
Publications and source records attributed to B H Scribner.
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Experience with use of the artificial kidney in the home led to the concept of self-infusion of parenteral nutrients at home. Originally called an artificial gut, the term has been changed to home parenteral nutrition. The original method proposed for circulatory access, a side-arm on an A-V shunt, failed and forced the development of a right atrial catheter which proved to be both safe and longlasting. A safe and rapid self-mix system of nutrient preparation was developed which made the patient independent of the hospital pharmacy. A wearable infusion device proved workable but was abandoned because it was unnecessary and greatly interfered with patient rehabilitation. A portable infusion system has been developed which facilitates patient mobility during infusions as well as patient travel.
UNLABELLED: The lack of peripheral neuropathy observed in peritoneal dialysis patients gave rise to the hypothesis that peritoneal membrane removes toxic solutes of larger dimensions than cuprophane membrane. Several "in vitro" and "in vivo" dialysis strategies have been selected. In the present paper the importance of residual renal function and the strategy of reduced dialysis schedule have been discussed. A trial with dialysis has been applied to 7 patients one of them treated for 20 months. CONCLUSION: the well being of peritoneal dialysis and low flow dialysis patients, confirm that the accumulation of small molecules, within certain limits, is not dangerous. On the other hand the middle molecules hypothesis has never been confirmed by observing a real toxicity of that solutes in dialysis patients.
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