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Biomedical subjects

B H Ong

Publications and source records attributed to B H Ong.

At least 37 records · Page 2Linked to original sources
PubMed1997

Malignancy arising in seborrheic keratosis: a report of two cases.

We describe the pathological features of two cases of malignant transformation occurring in seborrheic keratosis. The lesions affected elderly individuals: a 79-year-old Chinese lady and a 79-year-old Chinese gentleman, both of whom had long-standing seborrheic keratoses with recent increase in size. Histologically, the malignancies identified were invasive well-differentiated squamous cell carcinoma and Bowen's disease (squamous carcinoma in situ), respectively. Pre-existing seborrheic keratoses demonstrating a zone of transition into the malignant foci were present. Aetiologic factors that have been proposed to explain these exceedingly rare occurrences have included prolonged sun damage and chronic low dose radiation exposure.

Aged↗
PubMed1997

Sporotrichosis: a case report and successful treatment with itraconazole.

We report the case of a 51-year-old man who presented with a six-month history of a slowly growing plaque on the right ring finger and nodules over the right arm. Cultures grew Sporothrix schenckii. He was treated with itraconazole, 100 mg daily, with complete resolution of the lesions after five months of therapy. The differential diagnoses and the various modalities of treatment are emphasized.

Antifungal Agents↗
PubMed1995

Carcinosarcoma of the urinary bladder--case report and literature review.

We describe a patient who presented with gross haematuria and dysuria. Investigations confirmed a bladder tumour, for which transurethral resection was done. The histology showed a carcinosarcoma, which was muscle invasive but organ-confined. The patient refused radical surgery and underwent a course of radical radiotherapy. He died 14 months later. Carcinosarcoma of the urinary bladder is a rare, mixed malignant tumour, composed of mesenchymal and epithelial elements. It is commoner in elderly men. It is an aggressive tumour with a short clinical course, and must be distinguished from collision tumours and spindle cell tumours. Immunohistochemical stains are useful in its diagnosis. It is probably best managed by radical surgery with or without adjuvant therapy, but because of the small number of incidences reported, there is no universal agreement on its therapy.

Aged↗
PubMed1994

Papuloerythroderma of Ofuji: a report of three cases and review of the literature.

Papuloerythroderma of Ofuji is a rare, distinctive entity featuring widespread erythematous, flat-topped papules, with a striking sparing of body folds (the so-called 'deck-chair' sign), and peripheral eosinophilia. We report three elderly men who showed the typical features of this disease, and who responded to corticosteroid therapy. Immunohistochemical studies with anti-S-100 and UCHL-1 (CD45 RO) antibodies indicated the presence of abundant dendritic cells and mature T cells in the dermis. In addition, one patient had concomitant tinea corporis. Treatment with griseofulvin alone resulted in clearing of the fungal infection and improvement of his papuloerythroderma, and, worsening of his papuloerythroderma occurred when the tinea relapsed.

Aged↗
PubMed1994

Clinicopathological and immunohistological correlation of malignant lymphomas of the skin.

The study utilised monoclonal antibodies for T and B cells to study the immunophenotype in our lymphomas and to correlate with the clinicopathological aspects of eight cases of malignant lymphomas, of which four are cutaneous T cell lymphoma and four malignant lymphomas. The method used was immunohistochemical staining of tissue section by the alkaline phosphatase anti-alkaline phosphatase (APAAP) procedure. For four cases of cutaneous T cell lymphoma, three were in stage 1 and one in stage 2. The immunophenotypes were typical of mycosis fungoides-type cutaneous T cell lymphoma. They were predominantly T cells with many mature T cells. The CD4 to CD8 ratio fell within the normal range. There was no specific loss of CD7. For four cases of malignant lymphoma, T cell type, the pattern was again T cell phenotype with all of CD2, CD5, CD7 and CD4. The CD4 to CD8 ratios fell within the normal range except for one case, which showed a reversal of CD4/CD8, and this patient perished. His T suppressor cells were increased and had several cycles of malignant flare-up. One case showed mycosis fungoides, converting to lymphoma. This study demonstrates that monitoring of the progress is possible and can detect downgrading of malignant lymphomas.

Adult↗
PubMed1991

Peripartum haemoperitoneum.

We report the case of a young pregnant woman who presented with abdominal discomfort and giddiness. After an induced labour, the patient collapsed. Mid-line laparotomy revealed a ruptured and bleeding secondary deposit in the liver. A tumour of the sigmoid colon was also found.

Adult↗
PubMed1990

Coexisting follicular mucinosis and mycosis fungoides--a case report.

This is a case report of a patient with mycosis fungoides coexisting with follicular mucinosis. The simultaneous occurrence of these two conditions has been documented. There is controversy as to whether mycosis fungoides in patients with follicular mucinosis arises de novo or whether follicular mucinosis can evolve into mycosis fungoides. The relationship between the two conditions is discussed.

Adult↗
PubMed1989

Cutaneous metastases--an uncommon and unusual mode of presentation of gastric carcinoma.

Cutaneous and oral mucosal metastases from gastric carcinoma are very uncommon. It is even more uncommon and unusual to have a patient with gastric carcinoma whose mode of presentation is that of "skin nodule" (cutaneous metastases). We report one such patient, who was first seen in a skin clinic, then in a dental clinic, and finally was referred to a medical clinic. Current literature on cutaneous metastases of gastric carcinoma is reviewed in this case report.

Adenocarcinoma↗
PubMed1989

Primary malignant lymphoma of the cervix uteri: a case report.

Primary reticuloendothelial disease of the genital tract is an extremely rare condition. We encountered one such patient with diffuse large cell malignant lymphoma of the cervix uteri who presented with irregular vaginal bleeding. After complete haematological and radiological investigations, satisfactory treatment of the Stage I disease was achieved with total hysterectomy, bilateral salpingo-oophorectomy and post-operative pelvic irradiation.

Female↗
PubMed1988

Multicentric reticulohistiocytosis.

This is a short report on the first case of a multicentric reticulohistiocytosis diagnosed at Middle Road Hospital in 1987. He presented with multiple reddish brown papules and nodules but without arthritis. Systemic review did not show any associated malignancies. Treatment with methotrexate has not been useful. Multicentric Reticulohistiocytosis is a proliferative histiocytic disorder that is benign. It is characterised by a dermatoarthritis, extensive red nodule and a rheumatoid-like arthritis. Histologically, multinucleated giant cells in ground glass cytoplasma and mononuclear histiocytes form the granulomatous infiltrate that invades the dermis, mucosa, synovium and others--bone, plasma, pericardium etc.

Histiocytes↗
PubMed1987

Erythema nodosum leprosum in Singapore.

Erythema Nodosum Leprosum (ENL) or Type II reaction is an immune complex syndrome seen in multibacillary leprosy. 20 patients with histological confirmation of ENL in leprosy were studied from 1982 to 1986. These patients had a range of clinical signs, from fever, tender dusky nodules, bullae, ulcers to lymphadenopathy, arthralgia and neuritis. The four major histological patterns are: a) classical pattern showing heavy infiltrations of neutrophils in three cases, b) sub-epidermal bulla pattern with marked oedema of the upper dermis, and collections of neutrophils in five cases, c) vasculitis pattern, affecting superficial and mid-dermal vessels, leading to epidermal necrosis, bulla formation and ulceration. Dilated vessels, congestion, lumenal fibrin clots and fibrinoid necrosis of vessels were seen, d) non-specific picture in nine cases with mild oedema, infiltration with neutrophils, and two cases with minimal reaction had chronic ENL with clinical vasculitis. All the five cases with vasculitis showed C1q, C3 and fibrinogen in the vessels. Comparing ENL reactions reported in Asia, our pattern is similar to that of Malaysians with the majority showing sub-epidermal oedema. Vasculitis is more common in India. Oedema with collagen necrosis as seen in acute ENL with iritis in New Guinea. The Lucio's phenomenon was not seen in any of the countries in Asia.

Adult↗
PubMed1986

Bowenoid papulosis: a recent entity in sexually transmitted diseases.

Bowenoid papulosis is a recent phenomenon of multiple lesions with a histology of carcinoma in situ appearing on the genitals of young men. We report 6 male patients with this condition presenting with warty and/or lichen planus like lesions on the genitals. The histology shows carcinoma in situ. Three (50%) showed spontaneous regression, and the rest had persistence and recurrence. Repeat biopsy of one recurrent lesion showed a verruca. The evidence for a possible viral aetiology will be discussed. Long term studies are required to assess any oncogenic potential. As it is thought to be presently a viral infection with epidermal atypia, effective conservative management is sufficient.

Adult↗
PubMed1983

Early gastric cancer in Singapore.

Gastric cancer is one of the commonest malignancies in Singapore. 330 to 350 new cases are reported annually. Only about 8% of these cases undergo curative resection and the rest receive some form of palliative surgery. Early gastric cancer (i.e., cancer limited to mucosa and submucosa) is rarely diagnosed in Singapore. This paper presents 11 cases of early gastric cancer treated successfully by various Departments of Surgery over the past 5 years. All patients are well and free of tumour to date. The aim of this presentation is to remind clinicians of the importance of detecting early gastric cancer which has more than 90% 5 year survival rate.

Adult↗