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Biomedical subjects

B H Hyun

Publications and source records attributed to B H Hyun.

68 records · Page 4Linked to original sources
PubMed1977

Lymphoid follicles in bone marrow aspirates.

Lymphoid follicles were observed in 260 of 1,450 consecutive bone marrow aspirates (17.9%). As expected, the incidence of lymphoid follicles was less than those reported from autopsies (26.1-62.3%), but was twice as great as those in previous reports based upon study of aspirations (3.3-9.1%). The number of lymphoid follicles is also related to age and sex of the patient: they are rare in childhood and common after the fourth decade of life, particularly in women. Lymphoid follicles are found in higher incidence in bone marrow aspirates with plasma-cytosis and/or lipid granulomas than in those without these reactive changes. This relationship has not been described previously and suggests that the frequent occurrence of lymphoid follicles in the older age group may be a minifestation of a response to chronic immunologic stimulation.

Age Factors↗
PubMed1976

Blood recalcification time. A simple and reliable test to monitor heparin therapy.

The applicability of blood recalcification time as a laboratory test to assess and thereby regulate heparin anticoagulation was evaluated. Normal values for blood recalcification time ranged from 65 to 135 seconds, with a mean and standard deviation of 99 and 12 seconds, respectively. Duplicate determinations showed a mean variation of 5%. Blood recalcification times increased as a linear function of increasing heparin concentrations in vitro. Comparison with whole-blood clotting times revealed reasonably good correlation between the two tests. For whole-blood clotting times of 20 to 45 minutes the corresponding blood recalcification times were 142 to 212 seconds. The therapeutic range is often considered to be twice the normal range (130-270 seconds). In-vivo study revealed the peak blood recalcification time in the first sample collected 30 minutes after heparin injection, and a progressive decline thereafter to the pre-injection level during the subsequent 4 hours. The blood recalcification time is a simple, precise and clinically useful test to monitor heparin therapy.

Blood Coagulation↗
PubMed1976

Reactive plasmacytic lesions of the bone marrow.

A consecutive series of 1,000 bone marrow aspirates was analyzed for percentage of plasma cells, incidence of plasmacytic satellitosis, associated clinical disease states, lymphoid follicles, lipid granulomas, hemosiderin content, and various combinations thereof. Plasmacytosis was a common finding, and tended to parallel the presence of lymphoid follicles, lipid granulomas and plasmacytic satellitosis. The latter is emphasized as a normal phenomenon, may reflect morphologically a physiologic response of the B cell system to antigenic stimulation, and is conspicuously absent in plasmacytic neoplasia. Various secretory forms of plasma cells are illustrated.

Bone Marrow↗