Biomedical subjects

B H Dahl

Publications and source records attributed to B H Dahl.

3 recordsLinked to original sources

PubMed1989

[Burns among the elderly. Occurrence, causes, local treatment].

Burns in geriatric patients carry a grave prognosis. Reduced thickness of the skin and reduced mobility make older persons susceptible to deep burns. First-aid treatment is insufficient in most instances and generally, there is a delay in seeking medical treatment. Pre-existing degenerative diseases may account for numerous complications and a prolonged course. Accidents at home are most common. It is assumed that most of these could be prevented if proper precautions are taken. Our experiences from treatment of 85 geriatric burn patients at the Red Cross Clinic, Oslo, prompted the present study. We discuss various aspects of problems to geriatric patients.

Age Factors↗

PubMed1989

[Large breasts--big problems?].

Hypertrophy of the breast often leads to pain in the neck and shoulders. This group of patients comprises mainly employed women who are otherwise in good health. For many of them, the problems cause long periods of absence from work. We wished to find out to what degree the main symptoms of these patients were caused by large and heavy mammae. We also wished to ascertain whether operative reduction of the breasts has the desired effect of alleviating the problems. A questionnaire was sent to 99 patients. The response was 69%. We discuss the interpretation of the answers, and conclude that the problems reported by patients were to a large extent real and that the vast majority of patients had been helped by operation.

Adolescent↗

PubMed1987

Mechanistic studies on the phosphoramidite coupling reaction in oligonucleotide synthesis. I. Evidence for nucleophilic catalysis by tetrazole and rate variations with the phosphorus substituents.

Tetrazole catalyzed reactions of a series of phosphoramidites, 5'-O-DMTdT-3'-O-P(OR1)NR2(2) (1a-h), with 3'-O-SiButPh2-6-N-benzoyl-dA (2a) in acetonitrile solution have been studied. It is found that the coupling rate depends very much on whether tetrazole is added before or after 2a, and that dialkylammonium tetrazolide salts are inhibitors. These and other facts are evidence that the reactions are subjected to nucleophilic catalysis by tetrazole, in addition to acid catalysis. The rate variations with phosphorus substituents of 1a-h are NEt2 greater than NPri2 greater than N(CH2CH2)O greater than NMePh, and OMe greater than OCH2CH2CN greater than OCHMeCH2CN greater than OCMe2CH2CN much greater than OC6H4Cl. The inhibitor properties of dialkylammonium tetrazolides have practical consequences for the efficiency of DNA syntheses, when in situ prepared phosphoramidites are used; the same would apply for segmented, simultaneous syntheses or syntheses where recycling is performed.

Indicators and Reagents↗