Biomedical subjects

B H Cuthbertson

Publications and source records attributed to B H Cuthbertson.

24 records · Page 2Linked to original sources

PubMed1997

UK guidelines for the use of inhaled nitric oxide therapy in adult ICUs. American-European Consensus Conference on ALI/ARDS.

OBJECTIVE: Although unlicensed, inhaled nitric oxide (NO) therapy is now widely used in the United Kingdom. Our aim was to produce guidelines for the clinical application of inhaled NO in adult intensive care practice, based upon the current level of published information. METHODS: The published data regarding the use of inhaled NO in the acute respiratory distress syndrome and right-sided cardiac failure was presented, analysed and discussed. Recommendations based on these data as well as on current experience in the United Kingdom were formulated. DESIGN: An expert group comprising intensive care specialists from within the United Kingdom, representatives from the European Society of Intensive Care Medicine and the Society of Critical Care Medicine and individuals from the Departments of Health and Industry related to the field was assembled. RESULTS: United Kingdom guidelines for the indications, contraindications, dose, delivery, monitoring and scavenging of inhaled NO therapy were produced. CONCLUSIONS: The need for additional quality research to establish evidence of efficacy and safety was emphasized. The guidelines are designed to act within the context of current practice and knowledge and should be revised as further data emerge.

Acute Disease↗

PubMed1997

Use of inhaled nitric oxide in British intensive therapy units.

The use of inhaled nitric oxide in the critically ill has increased significantly over the past few years but little published information exists on standards for current practice. Sixty-four intensive therapy units in the UK were surveyed by questionnaire from which 54 (84.4%) satisfactory replies were received. We present the survey results and put forward recommendations based on current literature and our own clinical experience for the safe use of inhaled nitric oxide.

Administration, Inhalation↗

PubMed1997

Effect of exogenous nitric oxide and superoxide on interleukin-8 from human polymorphonuclear leucocytes.

Patients with acute inflammatory lung injury are commonly treated with inhaled nitric oxide. Nitric oxide has profound immunoregulatory effects. Increased concentrations of the cytokine interleukin-8 (IL-8) in bronchoalveolar lavage fluid has been associated with disease severity. We have investigated the effects of a nitric oxide donor and a combined nitric oxide-superoxide donor on lipopolysaccharide-mediated accumulation of IL-8 from cultured human neutrophils. Interleukin-8 was measured in culture supernatant after 20 h using enzyme immunoassay. The combined nitric oxide-superoxide donor, 3-morpholinosydnonimine (SIN-1), dose-dependently decreased lipopolysaccharide-mediated IL-8 accumulation (P < 0.01). SIN-1 also decreased IL-8 accumulation from unstimulated neutrophils (P < 0.001). In contrast, the pure nitric oxide donor, 1,2,3,4-oxatriazolium 5-amino chloride (GEA-3162), increased stimulated IL-8 accumulation (P < 0.01) and also increased IL-8 accumulation in unstimulated cells (P < 0.002). Nitric oxide and superoxide have profound effects on IL-8. These results have important implications for the treatment of patients with acute lung injury with inhaled nitric oxide.

Cell Culture Techniques↗

PubMed1996

Inhaled nitric oxide.

Explore the source record for details and available documents.

Administration, Inhalation↗

PubMedDate not supplied

Inotropic agents in the critically ill.

Inotropic agents are commonly used in critically ill patients. This heterogeneous group of drugs are potentially hazardous if used without a good understanding of cardiovascular physiology and pathophysiology and without due attention to some general principles for their use. We suggest guidelines for the administration of these agents in all clinical settings.

Cardiotonic Agents↗

PubMedDate not supplied

Nitric oxide in critical care medicine.

Few areas of medicine have failed to be affected by the discovery of nitric oxide and the unravelling of its many physiological and pathophysiological roles. Possibly no other area of medicine has this discovery had so many potential therapeutic applications as in the field of critical care medicine. But will this widespread interest in nitric oxide result in the promised revolution in clinical care?

Administration, Inhalation↗