Search PubMed⌕ Search

Biomedical subjects

B Gosselin

Publications and source records attributed to B Gosselin.

At least 289 records · Page 16Linked to original sources
PubMedDate not supplied

[Value of biopsy of accessory salivary glands for the diagnosis of amyloidosis].

There are few reports of amyloidosis diagnosed by deliberate biopsy of accessory salivary glands. Usually, a biopsy performed for dry mouth syndrome reveals an unsuspected amyloidosis. We report the case of 2 patients with lambda-type light chain monoclonal gammapathy complicated by generalized amyloidosis and in whom biopsy of the accessory salivary glands showed signs of amyloidosis. In the first patient accessory salivary gland biopsy was performed because these glands were enlarged, and the monoclonal dysglobulinaemia was subsequently diagnosed by serum immunoelectrophoresis. In the second patient with nephrotic syndrome, renal biopsy could not be carried out owing to the presence of a renal malformation; amyloidosis was confirmed by periumbilical fat aspiration, and a systematic biopsy of accessory salivary glands also showed evidence of amyloidosis. Biopsy of accessory salivary glands seems to be a particularly simple and safe method to detect generalized amyloidosis in patients with chronic inflammatory disease or monoclonal dysglobulinaemia.

Aged↗
PubMedDate not supplied

[Hodgkin's disease disclosed by myelofibrosis of primary appearance. Apropos of 2 cases].

Two male patients, aged 36 and 73 years respectively, gradually developed febrile pancytopenia with profound alteration of their general condition and major inflammatory repercussions. No superficial or deep lymph node enlargement was found initially. Patient n degree 2 had an enlarged spleen. In both cases histological examination of the bone marrow showed an extensive and apparently nonspecific myelofibrosis. The subsequent development of superficial lymphadenopathy provided a firm diagnosis of Hodgkin's disease with mixed cellularity. These two cases belong to the category of exceptional massive medullary forms of Hodgkin's disease described by Duhamel et al. in 1979.

Adult↗
PubMedDate not supplied

Airway-like inflammation of minor salivary glands in bronchial asthma.

Bronchial asthma is characterized by a chronic inflammation with accumulation of eosinophils, mast cells and activated T lymphocytes that release a large panel of cytokines. As the mucosal immune system comprises a series of specialized lymphoid tissues with a well-identified lymphocyte traffic between different compartments, we initiated a study to evaluate the histological abnormalities of minor salivary glands (MSGs) in patients with bronchial asthma. 58 patients were studied (29 with allergic asthma, 29 with nonallergic asthma) and compared to 15 healthy controls and 15 patients with chronic obstructive pulmonary disease (COPD). MSGs were normal in all controls except one and in 14/15 COPD patients. 43/58 asthmatics (74%) exhibited MSG abnormalities with T lymphocyte infiltration (57%), mast cell infiltration (64%), basement membrane thickening (64%) and endothelial cell changes (26%). Histological abnormalities were predominantly observed in nonallergic asthmatics. We propose that activated T lymphocytes, present in the bronchial mucosal lymphoid tissue in chronic asthma might migrate, colonize other glandular and mucosal sites, and so trigger at a distance, an airway-like inflammation.

Adolescent↗
PubMedDate not supplied

[Use of dopamine in the treatment of shock states].

The utilisation od dopamine at an average dose of 6 mug/kg/mn, for the treatment of 19 shock states, is proved to be of particular interest. The lapic action, the special amelioration of the left ventricular function suggest that dopamine is an useful drug in the treatment of circulatory failure and myocardial inefficiency. The renal and mesenteric vasodilatation produced, prevent or treat the acute renal failure of shock. The actions of dopamine are different from those of other vasopressive amines (norepinephrine, isoproterenol, glucagon) and make dopamine on the first drug to treat shock states.

Adult↗
PubMedDate not supplied

Non-Hodgkin's lymphoma and Sjögren's syndrome. An immunopathological study of 113 patients.

One hundred and thirteen patients with untreated non-Hodgkin's lymphoma were evaluated for Sjögren's syndrome (SS) using clinical and biological parameters, and a minor salivary gland biopsy. Concomitant immunophenotyping for T and B cells, and kappa and lambda chains was performed on both minor salivary gland and lymphomatous tissues. Patients with a positive focus score on examination of their minor salivary gland biopsy had a second biopsy, when possible, at the end of induction therapy. Fourteen of the 113 patients had SS according to the Greek criteria, and 4 of these 14 patients had an identical monotypic infiltrate in both their minor salivary gland and lymphomatous tissues. In all four cases this infiltrate disappeared from both locations when the lymphoma was in complete remission (CR). The 10 other patients with criteria for SS had a mixed infiltrate which persisted unchanged when the lymphoma was in CR. Among the 99 patients without SS, 12 had a positive focus score and an identical monotypic infiltrate in both their minor salivary gland and lymphomatous tissue. This infiltrate disappeared from both locations when the lymphoma was in CR. Among the remaining 87 patients, 82 had no minor salivary gland infiltrate, and 5 had a positive focus score with mixed lymphocytic infiltrate. Long term follow up and a large cooperative study are needed to better understand the immunopathologic lesions of patients of this latter type.

Adult↗
PubMedDate not supplied

Histological criteria of Sjögren's syndrome in scleroderma.

33 patients with scleroderma, xerostomia and xerophthalmia underwent biopsy of 3 to 5 labial salivary glands. Histological and ultrastructural study were systematically performed on the salivary gland specimen. In 27 patients, sclerosis was the main feature: it was an active fibrosis, with numerous secreting fibroblasts and degranulating mast cells. This fibrosis was located around capillaries and excretory ducts. It surrounded the acini, progressively destroying them. Lymphocytes were present but not very numerous. They were not grouped around the ducts but scattered in the fibrosis. 5 patients had similar fibrotic lesions but they also had numerous lymphocytes grouped in focus around excretory ducts as in primary Sjögren's syndrome. It is concluded that in scleroderma, xerostomia and xerophthalmia can be related either to a pure sclerotic process or to a 'common' secondary Sjögren's syndrome.

Fibrosis↗