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Biomedical subjects

B Goldstein

Publications and source records attributed to B Goldstein.

At least 217 records · Page 12Linked to original sources
PubMed1976

An integrated cardiorespiratory pathology information system.

An integrated computer system which is in its initial year of implementation has been developed to handle pathological data of cardiorespiratory organs. On the single entry of data captured at the source, the interactive computer system generates reports for administrative requirements by law, updates a data base of cardiorespiratory histopathological data for research purposes and facilitates inquiry for periodical management reports. The system is based on multiple-source documents which have numerically precoded choice option statements as well as free text provision for those statements where precoded options are not provided. The computer system has replaced manual system procedures most effectively in terms of cost.

Cardiovascular System↗
PubMed1976

The obligations of medical practitioners in relation to the new Mines and Works Act.

The Occupational Diseases in Mines and Works Act No. 78 of 1973 deals with compensation to be paid in cases of pneumoconiosis and other compensatable diseases such as tuberculosis, permanent obstruction of the airways and scleroderma. Any medical practitioner who attends a miner or worker from a 'works' such as Iscor, Amcor and several others at present controlled, is obliged, if death occurs, to remove the cardiorespiratory organs and forward them to the Medical Bureau for Occupational Diseases, unless the near relatives refuse permission for an autopsy. A pathologist who performs a routine autopsy on such a person must follow the same procedure.

Autopsy↗
PubMed1976

The electrophoretic hemolytic plaque assay -- theory.

We use the mathematical theory of plaque qrowth to determine if there is merit in performing a hemolytic plaque assay in the presence of an external electric field. In particular, we study the effects of an electric field on the transport of antibodies secreted by a single lymphocyte and on the size and shape of the plaques they produce. Our results indicate that in the presence of an applied electric field: (1) The mobility of the antibodies produced by the antibody forming cell can be determined from the plaque shape. (In the electric field the plaques are no longer circular, but cigar shaped.) (2) By changing the magnitude or direction of the applied electric field more than one plaque can be generated by a single AFC. Thus changes in mobility or the rate of antibody secretion can be assayed. (3) Plaques will reach a steady state size; for good emitters (cells that secrete antibodies at a high rate or that secrete high affinity antibodies) this steady state will be achieved rapidly. Equations are given which describe both the temporal development and steady state plaque size and shape. From the equations, computer generated plots of plaques produced by typical antibody forming cells are presented. These plots are then used to show how pictures of plaques formed in an electric field can be analyzed to determine the antibody mobility.

Electrophoresis↗
PubMed1976

[Familial form of centronuclear myopathy in the adult].

Two adult cases of centronuclear myopathy are described in a family from French Guyana. One of them, aged 23, has a slight weakness despite hypertrophic muscles. A typical picture of centronuclear myopathy was seen on muscle biopsy with atrophy of type I fibers and hypertrophy of II A fibers. His uncle, aged 53, had a progressive weakness of the lower limbs for the last 25 years, with also a pattern of centronuclear myopathy, but with more dystrophic features and atrophy of both type I and II A fibers. The mode of inheritance is dominant. These two cases are compared with the previously published reports. The pathogenesis of centronuclear myopathy is discussed.

Adult↗
PubMed1976

Benzene and lead inhibition of rabbit reticulocyte heme and protein synthesis: evidence for additive toxicity of these two components of commercial gasoline.

Both benzene and lead are known hematopoietic toxins. These compounds are components of commercial gasoline, and therefore pose an environmental risk. The present study demonstrates that benzene and lead individually inhibit both intact reticulocyte heme and protein synthesis in the presence or absence of iron-transferrin. When these two compounds are present in the same incubation, their effects are additive. These in vitro results suggest that further evaluation of the combined risks of benzene and lead is indicated. Furthermore, the data shows the potential for additive interaction by chemically unrelated environmental compounds.

Anemia↗
PubMed1976

[2 cases of post-radiation stenosis of the main cerebral artery trunks].

Two cases of common carotid stenosis as a late complication of radiotherapy are reported. One of them was treated by subclavian-carotid by-pass. Delayed lesions of medium and large arteries after radiotherapy are reviewed, with emphasis on the neck vessels--and the surgical possibilities.

Aged↗
PubMed1975

Theory of hapten binding to IgM: the question of repulsive interactions between binding sites.

Various workers in their studies of the binding of haptens to IgM have observed that at low hapten concentration IgM has an apparent valence of five or near five, while at high hapten concentration IgM has a valence of ten. A possible explanation for this is that there is an interaction between binding sites on the same F(ab')2 region of the IgM molecule. In this paper the theory for such an interaction is presented and an expression for the apparent valence is derived. It is shown that the apparent valence depends on both the interaction between binding sites on the IgM molecule and on the width of the affinity distribution which characterizes the antiserum. A broad affinity distribution can give an apparent valence of five even when there is no interaction between sites, i.e., even when the ten binding sites on the IgM molecule are identical and independent. The general properties of a Scatchard plot are also discussed. When there is no interaction between sites it is shown that the average affinity and the variance of the affinity distribution can be obtained from a Scatchard plot. To illustrate the theory, an antiserum with affinities characterized by a normal distribution is considered and a simple method is presented for determining alpha, the parameter which measures the width of the normal distribution.

Animals↗
PubMed1975

Ginseng: its history, dispersion, and folk tradition.

This article presents a historical comparison of the traditions surrounding and uses of ginseng in Asia and in North America, with a focus on the triangle formed by the Chinese, the North American Indians, and the white American residents. The medicinal and folkloric applications of ginseng by the Chinese were remarkably similar to those independently developed by various North American Indian tribes. White Americans, however, largely disregarded the herbal root medicinal qualities in favor of the lucrative economic gains available from the export of ginseng to supply the Chinese market. Information was gathered primarily from Western sources and whenever possible was either drawn from or corroborated by original eighteenth and nineteenth century publications.

Canada↗
PubMed1975

Systematic utilization of data for analysis of a pediatric emergency-room experience.

This report describes the systematic use of emergency-room data to (1) define the experiences of a group of pediatric interns in their emergency-room rotation (especially as they relate to their role as future pediatric practitioners), (2) evaluate, supervise, and learn from their performance in this primary care setting, and (3) provide an ongoing weekly list of illnesses diagnosed in the emergency room as an epidemiological sentinel for the larger community. The future applications of this type of systematic approach, perhaps with computer technology, offer the opportunity for comparison of delivery, quality, and cost of health care between various sources of primary care (emergency-room facilities, private physicians' offices, neighborhood health centers, and health maintenance organizations.

Child↗