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Biomedical subjects

B George

Publications and source records attributed to B George.

At least 199 records · Page 11Linked to original sources
PubMed1987

Hygromycin A, an antitreponemal substance. II. Therapeutic effect for swine dysentery.

This study was conducted to evaluate hygromycin A fed to growing swine at 1, 5, 10 or 20 g/ton feed for the control of Treponema hyodysenteriae-caused dysentery. Pigs provided carbadox at 50 g/ton feed served as an infected treatment control group. All pigs were orally, via stomach intubation, administered 100 ml of a T. hyodysenteriae broth culture. During the in vivo test, rectal swabs were taken for T. hyodysenteriae isolation, body weights of all pigs and the feed consumption was determined. All pigs were euthanized and necropsied at study end; the large intestine was cultured for T. hyodysenteriae and gross intestinal lesions were noted. T. hyodysenteriae-caused swine dysentery was successfully controlled by feeding hygromycin A at 5 g/ton. Hygromycin A medicated pigs performed as well as or better than carbadox-medicated pigs.

Animals↗
PubMed1987

[Tympanic and jugular paragangliomas. I. Clinical symptomatology and evaluation of extension. Apropos of 25 cases].

Based on a review of 25 cases of tympanic and jugular paragangliomas treated and followed up in the Lariboisière hospital, Paris between 1978 and 1986, clinical aspects and extension of these tumors are studied. The often long delay in making the diagnosis is related to lack of knowledge of presenting symptomatology, frequent discordance between functional and physical symptomatology exists, but remarkable progress has been made in assessment of extension of tumors using new imaging techniques, particularly angiography, which can also guide the preoperative embolization and surgical procedures.

Adult↗
PubMed1987

[Tympanic and jugular paragangliomas. II. Angiographic, surgical and irradiation treatment. Results. Indications. Apropos of 25 cases].

Results of treatment are reviewed in 25 cases of tympanic and jugular paragangliomas treated and followed up in the Lariboisière hospital, Paris between 1978 and 1986. Therapy has been transformed by the use of embolization but its non-negligible neurologic accident risks, whatever the carotid artery territory involved, justify prior weighing of indications for its application. New surgical technics allow more extensive exeresis, but intrapetrous extension to the nerve compartment of the jugular foramen and the anterior pericarotid region still raises difficult surgical problems and appears to be the principal reason for failure of treatment. Radiotherapy is very effective and applicable for inoperable forms, as a complement to incomplete surgical removal and for recurrences.

Cerebral Angiography↗
PubMed1987

[Intracranial arterial aneurysm. Differences in origin and prognosis in men and women].

A statistical model was defined from a series of 144 patients referred for a subarachnoid hemorrhage due to intracranial aneurysm rupture, occurred less than 3 days before admission. This model was then prospectively applied on a second series of 70 patients and allowed to find out four datas predicting the final functional result: age (p = 0.02), clinical status (p = 0.001), angiographic evidence of spasm (p = 0.01) and sex (p = 0.001). Concerning sex, functional result appears worse in women than in man. This more severe prognosis of aneurysmal rupture in woman is explained by the higher frequency of spasm (p less than 0.0005). This fact and the predominance of multiple aneurysms and localizations on the supraclinoid internal carotid artery (38.3% in females and 17.7% in males) suggest a different origin of intracranial aneurysms according to sex. Fibromuscular dysplasia might correspond to the datas here observed, and is currently explored.

Adolescent↗
PubMed1986

Actinomycotic osteomyelitis of the skull and atlas with late dissemination. A case of transient neurosurgical syndrome.

Actinomycosis of the skull and/or the vertebral column is extremely rare in previously healthy children and its diagnosis is difficult. A case is reported here involving the occipital bone and the atlas. The disease had started 4 years before diagnosis and presented as a neurosurgical affection in a 13-year-old-girl. The disease spread towards the retropharyngeal space and probably disseminated to the liver and the lung. Actinomyces israeli grew from cultures. Antibiotic treatment was successful.

Actinomyces↗
PubMed1986

Use of a venous assist device after repair of complex lesions of the right heart.

Sixteen patients underwent hemodynamic evaluation of a venous assist device after complex operations on the right side of the heart. The device consists of an inflatable abdominal binder attached to a Jobst extremity pump causing intermittent external compression of the abdomen. In addition, six of these patients were evaluated using total lower body compression for comparison. Modifications of the Fontan procedure were performed in 14 patients, mitral valve anuloplasty and tricuspid valve replacement in 1 patient and reconstruction of the right ventricular outflow tract for treatment of pulmonary atresia with intact septum in 1 patient. The patients' ages ranged from 23 months to 31 years (mean 10.7 +/- 1.8 years). Systemic blood pressure, right and left atrial pressures, heart rate and arterial-mixed venous oxygen saturation difference were recorded in each patient with and without the device in place. With the venous assist device, mean systolic pressure increased from 95 +/- 4 to 122 +/- 3 mm Hg (p less than 0.05) and diastolic pressure rose from 57 +/- 3 to 70 +/- 3 mm Hg (p less than 0.05). Left atrial pressure increased from 7 +/- 1 to 15 +/- 1 mm Hg and right atrial pressure from 15 +/- 1 to 23 +/- 1 mm Hg (both p less than 0.05). In addition, arterial-mixed venous oxygen saturation difference decreased from 29% without the device to 23% with the device in place (p less than 0.05). Total lower body compression gave similar results to intermittent abdominal compression alone.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1986

Endovascular treatment of vertebral arteriovenous fistulas in twenty-two patients.

Twenty-two cases of vertebral arteriovenous fistulas treated by embolization are reported. Although such fistulas are usually asymptomatic they may be occasionally responsible for tinnitus. Neurologic complications are exceptional. Spontaneous fistulas have been found predominantly in the C1-C2 region (9 of 13 cases), while post-traumatic fistulas were located in the C5-C6 region and were often iatrogenic in origin (7 of 9 cases). In 17 cases embolization caused definitive closure of the fistula, while the vertebral artery remained patent. In three patients it was also necessary to close the vertebral artery in order to occlude the fistula. In two instances, endovascular management failed to obliterate the fistula. At present, endovascular treatment is the simplest and one of the least aggressive therapeutic approaches to vertebral arteriovenous fistulas.

Angioplasty, Balloon↗
PubMed1986

Twelve months' follow-up by night sleep EEG after recovery from severe head trauma.

Night sleep EEG recordings were obtained in patients, 1, 6, and 12 months after recovery from severe head trauma with signs of brain stem dysfunction. Modifications of intra-sleep wakefulness (W.) and REM sleep were observed but none of slow wave sleep (SWS). At one month after regaining consciousness, the lower the initial level of brain stem dysfunction, the greater the sleep disturbances were. At six months, improvement was observed. At one year, sleep disturbances increased again mainly in patients between 35 and 45 years old. These results are best compared to those observed in normal but elderly people, over 70 years.

Adolescent↗
PubMed1986

Stimulation of muscle protein degradation by murine and human epidermal cytokines: relationship to thermal injury.

Accelerated muscle proteolysis is a characteristic of systemic reaction following trauma, sepsis, or extensive thermal injury. The factors involved in this accelerated muscle breakdown have not been fully described. However, recently leukocytic pyrogen or interleukin 1 (IL-1) have been implicated in the induction of muscle protein degradation in septicemia or trauma. The epidermal cytokine epidermal cell-derived thymocyte activating factor (ETAF) is biochemically and functionally similar to IL-1. Injury to skin can augment ETAF activity. Using a murine model, we found that thermal injury can significantly enhance ETAF/IL-1 activity in a dose-dependent fashion. In addition, ETAF can cause net muscle protein breakdown in vitro. Thus, increased amounts of ETAF produced by thermally injured skin may contribute to the accelerated muscle breakdown in extensive thermal injury.

Animals↗
PubMed1986

[Clinical and developmental aspects of small brain stem hematomas. Contribution of x-ray computed tomography].

In a review of 16 cases, the authors emphasize that small brainstem haemorrhages, diagnosed by CT-scan, can have a good outcome, most often spontaneously. Twelve hematomas were in the pons, four in the mesencephalon. Several clinical features were remarkable: consciousness was not or moderately impaired, focal symptoms and signs predominantly neuro-ophthalmologic were present. Involvement of the cranial nerves and long tracts occurred rarely in isolation. Arterial hypertension was the usual cause (50 p. cent); one normotensive patient with neurological disorders prior to the bleeding had an arteriovenous malformation, demonstrated angiographically. In two cases an obstructive hydrocephalus was surgically treated. Expected advances from CT-scan and magnetic resonance imaging (M.R.I.) are discussed.

Adult↗
PubMed1986

[Indications for revascularization of the distal cervical vertebral artery].

Since the development of the technique of revascularizing the vertebral artery in its transversal and suboccipital portions, 22 revascularisation procedures of the distal vertebral artery (above C2) have been carried out in 21 patients. The earliest cases have been followed up for more than 4 years and the technique has proved to be reliable, both from the clinical and anatomical points of view. The indications were based on restoration of the vertebral axis compromised by major lesions (stenosis: 2 cases, occlusion: 14 cases) of both vertebral arteries (13 cases) or of the dominant vertebral artery in symptomatic patients (3 cases). Surgery was also offered to preserve a vascular axis which had to be sacrificed for the treatment of potentially embolic disease (aneurysm or dissection: 3 cases) or hypervascular lesions (arteriovenous malformation, tumour: 2 cases). However, the indications for distal cervical vertebral artery revascularization should be carefully considered as it is impossible to evaluate the long-term tolerance of major vertebral arterial lesions.

Adolescent↗