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Biomedical subjects

B Genetet

Publications and source records attributed to B Genetet.

At least 145 records · Page 8Linked to original sources
PubMed1977

Idiopathic hemochromatosis and iron overload in alcoholic liver disease: differentiation by HLA phenotype.

HLA A and B antigens were determined in two groups of patients: 38 patients with idiopathic hemochromatosis (IH) and 22 patients with iron overload accompanying alcoholic liver disease (AH). As previously described, HLA A3 and HLA B14 antigens appeared more frequently in the IH group (76.3 and 28.9%, respectively) than in a control group of 204 subjects (27 and 3.4%). In the AH group the frequency of A3 (22.7%) and B14 (13.6%) was not significantly different from that observed in controls. The frequency of A3 was significantly lower in the AH group than in the IH group (P less than 0.001). On this basis a clear difference appears between the two conditions with iron overload, and genetic analysis of the results rules out the hypothesis that AH would be a heterozygous form of IH exposed by alcohol.

Adult↗
PubMed1976

[Cad antigen in the French population].

An investigation of Cad phenotypes in the French population had been carried out in 1973, in four Blood Transfusion Centers (Mulhouse, Nancy, Paris, Versailles), B and O red cells were tested with the Dolichos Biflorus lectin. Out of 78.528 donors, 56 were found to have the Cad antigen on their red cells. The mean frequency was 0,07%. Nevertheless, this frequency varied among the four above mentioned Blood Transfusion Centers: the observed differences were probably due to the preparation procedure of the Dolichos biflorus extract. The family investigation permitted the analysis of four families with at least three Cad individuals. The independence of the Cad system and of Auberger, Gc, Hp, C'3, PGM, Pac and ADA was demonstrated. A quantitative agglutination study on these Cad samples using the Dolichos biflorus lectin,and a selected AB serum showed a high variability of the erythrocyte Cad Strength, even within one family. Most Cad samples were found polyagglutinable when a sensitive technique and selected AB sera were used. All adult sera contained an anti-Cad1 antibody, except Cad1 individuals. Although strong Sda reactivity was always found in Cad red cells, the anti-Cad and anti Sda specificities were not identical: this was demonstrated by the absorption and inhibition tests of anti-Cad and anti-Sda reagents absorption and inhibition tests of anti-Cad and anti-Sda reagents with Sda material. From thf Cad red cells, there was no evidence of the existence of separable anti-A1 and anti-Cad agglutinins in the Dolichos biflorus lectin.

Blood Group Antigens↗
PubMed1976

Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.

The frequency of HLA-A3 and HLA-B14 antigens was significantly higher in a series of 51 patients with idiopathic haemochromatosis than in a control group, being respectively 78-4 versus 27-0% and 25-5 versus 3-4%. This finding strongly supports the suggestion that idiopathic haemochromatosis is a genetic disease and suggests that the gene(s) responsible for the disease may be linked to the histocompatibility genes.

Adult↗
PubMed1976

[Tissue groups and ophthalmology].

By typing of 90 patients with ocular pathology (uveitis, diseases of optic nerve, Eale's disease, pseudo-tumor cerebri) the authors have found a constant and significant increase in the frequency of H.L.A. A2 especially in uveitis by streptococcus. However, a frequency of H.L.A. B27 as elevated as in previous publications was not found--but the parallelism: H.L.A. B27--ankylosing spondylitis was always found. Finally, the authors emphasized the haplotype H.L.A. A2 H.L.A. B5 in two cases of pseudo-tumor cerebri.

Adolescent↗
PubMed1976

[Major histocompatibility system in multiple sclerosis].

The comparison of Histocompatibility Testing in 82 MS Patients and 368 controls is presented. The increase in HL-A7 and decrease in HL-A12 are confirmed. A significant increase in HL-A8 is reported. Mixed Lymphocyte Reaction confirms the LD7a increase (19 out of 24 Multiple Sclerosis patients tested); 100% of the patients bearing the HL-A7 determinant are found to be LD7a. The presence of specific Immune Response genes in Multiple Sclerosis is discussed.

Histocompatibility Antigens↗
PubMed1975

[Determination of LD7a structures on human lymphocytes].

The non-stimulation of DNA synthesis in human lymphocytes in the one way mixed lymphocyte culture conditions allows the typing for LD determinants. The authors describe their technique together with their cryo-preservation procedure and the results obtained in 24 control population and 26 multiple sclerosis patients tested for the presence of the LD7a determinant.

Histocompatibility Antigens↗