Search PubMed⌕ Search

Biomedical subjects

B Gay

Publications and source records attributed to B Gay.

At least 91 records · Page 5Linked to original sources
PubMed1977

[Central hemodynamics and left ventricle contractility in experimental septicemia].

A well-defined septicaemia in dogs was induced using different initiating causes, such as abscess of thigh and peritonitis. The determination of the septicaemia was based upon both quantitative (number of bacteria) and qualitative criteria (staphylococcus aureus, pseudomonas aeruginosa). The hemodynamic changes lead to the classification of three time intervals, which occur constantly. There are correlations between the general infection and the reaction of blood circulation. There is no evidence of specific types of shock corresponding to the type of bacteria. Correlations exist between the moment when endotoxin is present and the occurrence of low-cardiac-output shock-syndrome. A disturbance of myocardial contractility develops in all types of shock in septicaemia. The decrease of contractility correlates in time with the first duration of the presence of the endotoxin. Several causes of the negative inotropic effects are discussed. Some of these are possible cardiotoxic effects of endotoxin shock mediators, lactate acidosis, and the decrease of coronary perfusion pressure.

Animals↗
PubMed1977

[Functional studies of the cardia muscles in achalasia].

1. The mechanical properties - extension behaviour and ability to contract per muscle cross-section - were the same for healthy and aganglionic cardiac sphincter. 2. The acetyl choline threshold is higher in aganglionic muscle strips. The maximum effective acetyl choline dose (2 microgram/ml) remained the same. 3. Achalasia is characterized by a considerable reduction of adrenergic beta-receptor activity and alpha-receptor predominance.

Acetylcholine↗
PubMed1976

Megacystis-microcolon-intestinal hypoperistalsis syndrome: a new cause of intestinal obstruction in the newborn. Report of radiologic findings in five newborn girls.

Five newborn girls presented with small intestinal obstruction and microcolon and a giant bladder (megacystis). Organic causes of obstruction were not found, and the gastrointestinal tract failed to function after appropriate diversion. Two died in the postoperative period, two lived several months on central venous hyperalimentation, and one died at 34 months of age following chronic though intermittent hyperalimentation. Pathologic studies showed an abundance of ganglion cells in both dilated and narrowed areas of intestine; the combined small bowel-colon length was one-third of normal in the absence of an evident obstructive or vascular insult. The five patients represent the most severe manifestation of defective intestinal peristalsis in a larger group of distended newborns in whom organic gastrointestinal obstruction is not found. Treatment with central venous hyperalimentation may sustain life, and some patients eventually recover gastrointestinal function. The hypoperistalsis is largely refractory to pharmacologic treatment; its cause is unknown.

Abnormalities, Multiple↗
PubMed1976

[Contractility of the left ventricle in experimental septicemia].

In experimental septicemia a decrease of myocardial contractility could be demonstrated. Periodically a correlation between disturbance of contractility and endotoxinemia exists. Starting point of infection and type of bacteria were of no detectable influence. As far as the disturbance of contractility is concerned one must take into consideration the cardiotoxic effect of endotoxin, the influence of shock mediators, lacticemia as well as the decrease of coronary perfusion pressure.

Animals↗
PubMed1975

Exposure to halogenated hydrocarbons in the indoor environment.

The indoor environment has frequently been ignored as a significant source of exposure to air pollutants. To date there are a number of documented examples of levels of indoor air pollutants greatly exceeding those levels which commonly occur in the outdoor environment. Among these instances are airborne buildup of polynuclear aromatics and cadmium from cigarette smoke, lead from burning candles, and vinyl chloride from use of aerosols containing this substance as a propellant. These examples suggest that there may be additional sources of indoor air pollutants, particularly halogenated hydrocarbons from aerosol products, which have heretofore not been generally recognized as important. The present paper endeavors to review those instances where halogenated hydrocarbons in the indoor air environment may build up to concentrations of potential public health concern. These considerations may be especially relevant in future years as increasing efforts are being made to insulate buildings more efficiently as a means to conserve energy. The available data strongly suggest that halogenated hydrocarbons are an important class of air pollutants in the indoor environment and that their presence in the outdoor environment should also be carefully examined. In this regard, halogenated hydrocarbons in the outdoor environment may also contaminate indoor air spaces.

Aerosol Propellants↗