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Biomedical subjects

B G Uzman

Publications and source records attributed to B G Uzman.

35 records · Page 2Linked to original sources
PubMed1970

Pneumocystis carinii.

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Complement Fixation Tests↗
PubMed1970

Retardation of peripheral nerve myelination in mice treated with inhibitors of cholesterol biosynthesis. A quantitative electron microscopic study.

The effect of two inhibitors of cholesterol biosynthesis, triparanol and AY 9944, on peripheral nerve myelination, was studied. Suckling mice were intraperitoneally injected with both drugs on 3 consecutive days and were sacrificed 6 hr after the last injection; others were suckled by an injected mother and sacrificed at 2(1/2) days of age. A single mouse which had been injected with both drugs at 1, 2, and 3 days of age was sacrificed 2 wk after the last injection. Membranous and crystalline intracytoplasmic inclusions were observed in the Schwann cells of the sciatic nerves of all the experimental animals. Both the number of unmyelinated single axons and the number of myelin lamellae around each myelinating axon in the sciatic nerves were recorded for treated mice and of mice suckled by treated mothers. The sciatic nerve of the experimental mice contained a larger proportion of unmyelinated single axons and smaller numbers of myelin lamellae around the myelinating axons, when compared with age-matched controls. The results suggest that a decrease of endogenous cholesterol in suckling mice may affect peripheral nerve myelination in two ways: by retarding the "triggering" of myelination in unmyelinated axons and by decreasing the rate of myelination already in progress.

Age Factors↗
PubMed1966

Nature of the packing of ribosomes within chromatoid bodies.

Optical Fourier transformns, made of electron mnicrographs of the crystalline array of ribonucleoprotein known as chromatoid bodies of Entamoeba invadens, have been interpreted as the transforms of a helix of 12 nodes in five turns. A model shows that this helix may be built of spheres 180 angstroms in diameter, placed at a radius of 150 angstroms. The optical transform of the model is very similar to the transform of the original electron micrograph.

Animals↗