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Biomedical subjects

B G Lamberty

Publications and source records attributed to B G Lamberty.

At least 19 recordsLinked to original sources

Spread of a recurrent lentigo maligna into a graft: a case for conservative treatment.

Lentigo maligna is an in situ malignant melanoma for which the treatment of choice is surgical excision. The recurrence rate in lentigo maligna is high and hence other treatments, such as cryotherapy, laser therapy, radiotherapy and Mohs' chemosurgery, have been described. Despite the high recurrence rate, spread of a lentigo maligna into a skin graft is rare. We describe a case of a recurrent lentigo maligna spreading into a skin graft, which, along with the cases described in the literature, highlights the presence of a group of low-grade malignant lentiginous lesions that may be managed by careful follow-up and observation.

Aged↗

A prospective, randomized, double-blind trial of the use of fibrin sealant for face lifts.

Fibrin sealant imitates the final phase of the blood coagulation process. Fibrinogen is converted into fibrin on a tissue surface by the action of thrombin, which is then cross-linked by factor XIIIa, creating a mechanically stable fibrin network. This fibrin network is thought to reduce the amount of postoperative bleeding by sealing capillary vessels and allowing raw operative surfaces to adhere. The authors conducted a prospective, double-blind, randomized, controlled trial on the use of fibrin sealant in 20 consecutive patients undergoing bilateral face lifts by the same surgeon. Each patient was randomized for the use of fibrin sealant on either the right or the left side with the contralateral side acting as the control. Total drainage was recorded on each side for 24 hours before drains were removed. The age range of the patients in the trial (all of whom were women) was 44 to 70 years (mean, 55). The side treated with fibrin glue had a median drainage of 10 ml and the control side 30 ml. The Wilcoxon signed rank test shows a significant difference in drainage between sides (p = 0.002). The reduction in postoperative drainage could also reduce pain and bruising, increasing patient satisfaction with this procedure. The need for drains may also be obviated.

Adult↗

Technique for uniform reduction of macroglossia.

Congenital macroglossia is a relatively uncommon condition characterised by enlargement of the tongue disproportionate to the rest of the dentoalveolar structures. It may cause significant symptoms in children. It is important to achieve uniform global reduction of the enlarged tongue for functional as well as aesthetic reasons. It is also important to preserve the mobility and sensation of the tongue. We describe a technique which meets these criteria.

Female↗

Anti-silicone antibodies and silicone containing breast implants.

The detection of anti-silicone antibodies in patients with silicone breast implants (SBI) has been undertaken principally in the USA. We undertook a study of 20 women with SBI from different manufacturers from 6 weeks to 20 years after surgery, including those with ruptured implants. They were compared with three control groups: 20 women without implants, 20 women with auto-immune disease and 20 anonymous blood donors. Potential anti-silicone antibodies (IgG) were tested against a variety of silicone polymer antigens using an enzyme linked immunosorbent assay (ELISA) technique which had previously detected positive results in an uncontrolled series. Silicone-free collecting tubes were used. No differences were found between the patients with SBI and controls. However, samples that had been stored for the longest time, or frozen and thawed several times, had the highest levels. These false positives appear to be due to an unknown but human specific IgG binding phenomenon. We conclude that there is no demonstrable anti-silicone antibody formation in these patients with SBI and we would caution that the effect of storage may have been an important factor in previously published assay methods. This study supports the safety of silicone containing breast implants.

Adolescent↗

Massive plexiform neurofibroma of the sympathetic trunk.

A case report of a massive plexiform neurofibroma of the sympathetic trunk is reported. Symptoms included dysphagia, shortness of breath and paraesthesia of the right hand. The nerve of origin and extent of the tumour were unusual. The tumour mass partially filled the right hemithorax, surrounded the right brachial plexus, extended to the base of skull and invaded the cervical vertebrae threatening to compromise the spinal cord. Surgical resection required combined cardiothoracic, neurosurgical and plastic and reconstructive surgical teams. Early outcome following surgery was excellent. This case illustrates the need for a combined surgical approach for such a lesion and we believe it is the first reported case of plexiform neurofibroma of the sympathetic trunk.

Female↗

Gynaecomastia: have Webster's lessons been ignored?

Five cases of cosmetically unacceptable and hypertrophic scarring are presented that follow excision of gynaecomastia by surgeons who used incisions other than the periareolar approach. A periareolar technique of subcutaneous mastectomy is described and recommended.

Adolescent↗

What do plastic surgeons do?

The image of plastic surgery as portrayed by the media is of concern to all plastic surgeons. In order to assess knowledge about the specialty, a questionnaire was devised and given to five groups of participants: general practitioners, medical students, nurses, plastic surgical out-patient attendees, and the general public. The results revealed that general practitioners, nurses and medical students in the Cambridge area are, on the whole, knowledgeable about the role of plastic surgery. However, the general public are not so well educated and 23.7% of them could not think of five conditions treated by plastic surgeons, and felt that burns and cosmetic problems were the commonest conditions dealt with. Improved liaison with general practitioners, other specialties and more teaching of undergraduates, coupled with more effective promotion of the skills on offer might permit better use to be made of the specialty.

Health Knowledge, Attitudes, Practice↗

Rotation fasciocutaneous flap repair of lower limb defects.

The rotation design was applied to fasciocutaneous flap repair of lower limb defects to produce a functional and aesthetic result superior to that obtained by the transposition design. A prospective, consecutive series of 21 patients is reported, 14 males and 7 females, ranging in age from 17 to 81 years (mean 43 years). The primary defects, 8 traumatic, 12 cutaneous malignancy excisions, and 1 radionecrotic ulcer, ranged in size from 3.5 x 3 cm to 10 x 8 cm (mean 6.6 x 5 cm). The rotation fasciocutaneous flap base ranged from 5 to 25 cm (mean 12 cm), and the radius ranged from 4.5 to 20 cm (mean 9 cm). The inclusion of a back-cut at the flap base permitted direct donor-site closure in all but one patient, obviating the need for a split-thickness skin graft and avoiding the otherwise inevitable significant contour defect. Postoperative bed rest ranged from 3 to 7 days (mean 5 days). Three minor and no major complications occurred, and there was complete survival of all flaps. The results in this series indicate a role for the rotation fasciocutaneous flap in the management of traumatic and excisional defects in the lower limb. It has proved reliable, gives good aesthetic results, and reduces treatment costs.

Adolescent↗

Perineural infiltration in basal cell carcinomas.

4376 basal and squamous cell carcinomas were dealt with over a period of 100 months. 76.6% of these were basal cell carcinomas. Perineural spread was noted in 0.178% of basal cell lesions and in all examples was found in recurrent tumours, which were predominantly in the preauricular and malar areas in this series.

Aged↗

Giant cell tumours in mandible and spine: a rare complication of Paget's disease of bone.

The case of a man who was diagnosed as having polyostotic Paget's disease at the age of 52 years is described. He developed a rare neoplastic complication of Paget's disease--a giant cell tumour in his mandible, which was excised. Nine years after the diagnosis of this tumour he developed a new giant cell tumour arising from the L3 vertebral body. He was born in Avellino in Italy, from where five other cases of giant cell tumours arising from Pagetic bone disease have been reported. No family relationship between our patient and the other cases was established. His Paget's disease was particularly aggressive and resistant to treatment with two single high dose infusions of pamidronate almost two years apart.

Aged↗

Fasciocutaneous flaps.

It is difficult to be objective about the fasciocutaneous system of flaps, whose development continues at an alarming speed. The references cited in this article, by no means comprehensive, are testimony to that. We have tried to be selective in our choice of reference, and anyone familiar with these references will have a good understanding of the fasciocutaneous system. These flaps have been recognized for less than 10 years, but their origins have been well based on an anatomical foundation. The revival in the anatomical basis of flaps, whether they be skin based, muscle based, or fascia based, is, we think, one of the most significant factors in the huge advance we have seen in reconstructive techniques in the last decade. To put reconstructive surgery in perspective, we see it in the following way: 1. Distant origins from ancient Egypt through Tagliacozzi to Dieffenbach. 2. The birth of modern reconstructive surgery, 1900 to 1930. 3. Skin flaps and the age of the tube, 1930 to 1960. 4. Anatomical renaissance; the axial skin flap and microsurgery. 5. The 1970s, decade of the muscle and musculocutaneous flaps. 6. The 1980s, decade of the fasciocutaneous flap. We repeat that to see our present efforts objectively is difficult. What is close to us seems more important, but as we progress further away from the origins of the fasciocutaneous flap, some aspects of these flaps will be seen as more important than others. The concept of including the fascia to produce a composite fascial skin flap is of fundamental importance. The discovery of these flaps is a milestone in reconstructive surgery. Our anatomical understanding of all flaps is also of paramount importance. Some of the individually described fasciocutaneous flaps will always remain best buys; some will be forgotten--and maybe even rediscovered.

Extremities↗

Cadaver studies of correlation between vessel size and anatomical territory of cutaneous supply.

The anatomical territories of individual vessels supplying the skin and subcutaneous tissues have been measured in specimens of cadaver skin following intra-arterial whole-body barium sulphate injection. An attempt has been made to correlate these area measurements with measurements of the diameters of individual vessels. A method has also been devised for measuring the "axiality" of the territories of distribution of individual perforators.

Blood Vessels↗