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Biomedical subjects

B G Gafurov

Publications and source records attributed to B G Gafurov.

At least 19 recordsLinked to original sources
PubMed2005

[An experience of intra-arterial thrombolytic therapy of ischemic stroke in Uzbek republic center of emergency care].

Acute period of stroke is a crucial stage of the disease. The differential therapy in the first 3-6 h from the onset of acute ischemic stroke, so-called "therapeutic window", is of special importance. Obviously, favorable clinical outcome in such patients is largely depends on the early recanalization during "therapeutic window". Presented, are the results of intra-arterial thrombolysis in patients with ischemic stroke, which reveal its high therapeutic effectiveness. Though there was limited clinical evidence for a high effect of recanalization of intra-arterial thrombolysis, this approach opens new perspectives for large scale clinical investigations using endovascular methods in thrombolytic therapy of patients with ischemic stroke.

Adult↗
PubMed2004

[Clinical and pathogenetical peculiarities and treatment policy in ischemic stroke of elderly and old age].

The data on randomized study of 2 groups of patients with ischemic brain hemisphere stroke of elderly and old (over 70 years) as well as middle (under 60 years) age are presented. In elderly and old age, stroke develops on the basis of common affection of major vessels, with a great role of the "steal syndrome" in its pathogenesis. In authors' opinion, in treatment of ischemic stroke of elderly and old age attention should be paid to metabolic therapy, in particular to using high dosages of Cerebrolysin. Basing on clinical and paraclinical study, efficacy of this medication is revealed.

Age Factors↗
PubMed2003

The diagnostic significance of electrophysiological analysis of an orientational reflex in hemispheric ischemic stroke.

This report presents data from studies of the diagnostic significance of an orientational reflex (OR) to indifferent sound stimuli in hemispheric ischemic stroke. The following electrophysiological measures of the orientational reflex were studied: the desynchronization reaction, the non-specific EEG vertex potential, and spontaneous electrodermographic activity (skin galvanic reactions, SGR) in response to presentation of repeated sudden indifferent sound stimuli. Studies were performed during the course of illness, starting with the acute period of stroke. The results obtained from these studies showed that the severity of stroke correlated with preservation of the OR while the rate of extinction of individual components in the early recovery period correlated with the hemispheric lateralization of the pathological focus and the severity of the neurological defect.

Acoustic Stimulation↗
PubMed2002

[Autonomic system disorders in patients with myasthenia gravis].

Using a set of techniques, segmentary and nonsegmentary autonomic nervous system compartments were studied at rest and under stress. Parasympathicotonia, on the background of general deficit of ascending nonspecific brain activity, was found to characterize myasthenia in general. A decrease of nonspecific brain activity level is combined with elevated anxiety. However, one may distinguish a generalized type of the disease by the presence of dissociation of the autonomic nervous system compartments due to sympathicotonia.

Adaptation, Physiological↗
PubMed2002

[The diagnostic significance of electrophysiological analysis of orientation reflex in hemispheric ischemic stroke].

Diagnostic significance of orientation reflex in response to neutral sound stimuli in hemispheric ischemic cerebral stroke is discussed. The following electrophysiological indices for orientation reflex were analysed: desynchronization reaction, non-specific vertex EEG potential and spontaneous electrodermographic activity--galvanic skin reflex to repeated sudden neutral audio stimuli were analysed. Beginning from the acute period of stroke, a follow-up study was carried out. Correlations between stroke severity and orientation reflex stability as well as between a rate of some pattern diminution in the early rehabilitation period and hemispheric lateralization of the pathological focus and severity degree of the neurological deficit were found.

Aged↗
PubMed1997

[Role of autonomic dysfunction syndrome in the etiology of pre-stroke forms of cerebrovascular pathology in women of young age].

30 women aged 30-45 years with the diagnosis "initial manifestations of insufficiency of cerebral circulation" were examined. These disorders were observed on the background of the syndrome of autonomic dysfunction. Correlative analysis was performed by means of methods which permitted quantitative estimations on the basis of investigation of the severity of the syndrome, peculiarities of the patients' mental state and cerebral hemodynamics. Pronounced correlation was found between hemodynamic indices and the degree of anxieties. Anxiety plays an inducing role in the development of either autonomic dysfunction or the main vascular disorders. The syndrome of autonomic disfunction was considered as the realising factor.

Adult↗
PubMed1996

[Psychoautonomic disorders in bronchial asthma patients].

The results of psychological and vegetative investigations in 142 patients with bronchial asthma (BA) demonstrated that BA gives rise to psychovegetative syndrome resultant from parasympathetic orientation of the vegetative tone and reactivity, weak vegetative support of muscular and mental activity. These vegetative shifts occur in line with enhanced ascending nonspecific activation and anxious-hypochondriac traits of personality.

Adolescent↗
PubMed1993

[The autonomic dystonia syndrome in pathological climacteric in women and cerebrovascular insufficiency].

The authors analyze some pathophysiologic mechanisms underlying the relationships between the vegetative dystonia syndrome running in the presence of the climacteric syndrome, on the one hand, and cerebrovascular insufficiency, on the other. A total of 82 women were examined, 62 of these with the climacteric syndrome and 20 with the normal climacteric (reference group). Among women with the climacteric syndrome patients with signs of cerebrovascular insufficiency (initial signs of cerebral circulation insufficiency and Stage I dyscirculatory encephalopathy) predominated. The severity of cerebrovascular insufficiency was higher in patients with the climacteric syndrome. The sympathetic tone of the autonomic nervous system clearly prevailed in the test group, and signs of inadequate autonomic supply were present. Electropolygraphic registration of the function of the nonspecific systems of the brain has shown marked signs of increased level of the ascending nonspecific activation of the brain in the main group as against the reference one. Basing on these findings, the authors analyze the specific features of the psychovegetative syndrome, conducive to the development of cerebrovascular dystonia in women with the pathologic course of the climacteric.

Autonomic Nervous System↗
PubMed1992

[Status of the nonspecific systems of the brain in initial manifestations of insufficiency of cerebral blood supply and circulatory encephalopathy].

Function of the nonspecific brain structures (NBS) was examined in 49 patients distributed into two groups: with initial manifestations of brain blood supply insufficiency (IMBBSI) (n = 28) and atherosclerotic encephalopathy (n = 21). Use was made of an approach with the use of autonomic and psychological techniques as well as of a polygraphic recording of the electrophysiological parameters of nocturnal sleep. It has been established that both groups patients manifest NBS dysfunction. However, its qualitative characteristics were found to differ noticeably in IMBBSI and AE. The patients with DE demonstrate more remarkable inhibition of the synchronous mechanisms that regulate both phases of nocturnal sleep and reciprocal enhancement of the activity of the systems of the ascending nonspecific brain activation. The autonomic and psychological data agree with the electrophysiological data obtained. The conclusion is drawn that in patients with cerebrovascular insufficiency, the NBS systems are first of all involved in the pathological process. This is of importance for both the diagnosis and further studies into the pathogenesis of different forms of cerebrovascular insufficiency.

Adult↗
PubMed1992

[The participation of the sensorimotor cortex in assessing the quality of food reinforcement against a background of thirst].

In trained cats, unilateral extirpation of the sigmoid gyri's cortex disinhibited the unreinforced runs while preserving the positive conditioned reflexes associated with differentiation of different salt food reinforcement. The bilateral extirpation induced a disorder of differentiated inhibition while preserving the conditioned runs reinforced with the highly salted food. The unilateral extirpation did not affect the food-motor conditioning against the background of the salt diet. The bilateral extirpation delayed the differentiation inhibition and facilitated the positive conditioning.

Animals↗
PubMed1992

[The characteristics of the autonomic disorders in acute cerebral circulatory disturbances].

The problem of the role of the autonomic nervous system (ANS) in the mechanism of symptom formation and in the pathogenesis of acute disturbances of cerebral circulation (ADCC) has not been studied well. Bearing this in mind, the authors examined 78 patients who suffered ADCC. The patients were divided into 2 groups. The first group was made up of 50 patients who suffered ischemic brain stroke with a stable neurological defect (SSD), the second one comprised 28 patients who suffered brain stroke with a reversible neurological defect (SRD). It has been established as a result that the initial level of sympatheticotonia and the intensity of the signs of vegetodystonia was higher in patients with SSD. Electrophysiological studies have demonstrated that in SRD, the level of ascending nonspecific brain activation prevailed according to the responsiveness of the reference alpha-rhythm as compared with the first group patients and the control group. The data obtained are discussed from the standpoint of the compensatory role played by the autonomic nervous system in the pathogenesis and course of the clinical forms of ADCC differing in the gravity and prognosis.

Acute Disease↗
PubMed1991

[Conditioned-reflex food selection in mongrel white rats exposed to high temperature].

Under condition of normal temperature the conditioned reflectory runnings of rats on the audible irritants were developed more quickly during dry food than damp one. Daily influence of high temperature during two hours and partially water deprivation resulted in reduction of the conditioned reflex which had been developed before during dry food. The reproduction of the conditioned reflexes during dry food failed. The essential changings in the conditioned reflexes during damp and dry food were not found when animals had become overheating without restriction of water consumption. During daily heat affecting at the end of the second week animals adapted to high temperature. This statement is confirmed by lowering the rectal temperature, decrease of the breath rate, daily water consumption and restoration of the activity of conditioned reflexes.

Acoustic Stimulation↗